Collagenase-2 and -3 are inhibited by doxycycline in the chronically inflamed lung in bronchiectasis

Annals of the New York Academy of Sciences

Volumn 878, Issue , 1999, Pages 683-685

  Sepper, Ruth ^a   Prikk, Kaiu ^c   Tervahartiala, Taina ^c   Konttinen, Yrjö T ^c   Maisi, Päivi ^c   Lópes Otín, Carlos ^b   Sorsa, Timo ^c  

^a Institute of Experimental and Clinical Medicine Tallinn   (Estonia)

^b UNIVERSITY OF OVIEDO   (Spain)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; COLLAGENASE INHIBITOR; DOXYCYCLINE;

ADOLESCENT; ADULT; BRONCHIECTASIS; CLINICAL ARTICLE; COLLAGEN DEGRADATION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HUMAN; LUNG LAVAGE; MALE;

EID: 0032816214     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07761.x     Document Type: Conference Paper

References (4)

1. 1. Sepper, R., Y.T. Konttinen, T. Sorsa & H. Koski. 1994. Gelatinolytic and type IV collagenolytic activity in bronchiectasis. Chest 106: 1129-1133.
2. 2. Sepper, R., Y.T. Konttinen, Y. Ding, M. Takagi & T. Sorsa. 1995. Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease. Chest 15: 27-34.
3. 3. Golug, L.M., N.S. Ramamurthy, T.F. McNamara, R.A. Greenwald & B.R. Rifkin. 1991. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit. Rev. Oral Biol. Med. 2: 297-321.
4. 4. Sorsa, T., P.L. Lukinmaa, U. Westerlund, T. Ingman, Y. Ding, H. Tschesche, H. Helaakoski & T. Salo. 1996. The expression, activation and chemotherapeutic inhibition of matrix metalloproteinase-8 (neutrophil collagenase/collagenase-2) in inflammation. In Biological Mechanisms of Tooth Movement and Craniofacial Adaptation. Z. Davidovich & L.A. Norton, Eds.: 317-323. Harvard Society for the Advancement of Orthodontics. Boston.