Analysis of the interaction of TIMP-2 and MMPs: Engineering the changes

Annals of the New York Academy of Sciences

Volumn 878, Issue , 1999, Pages 524-527

  Hutton, Mike ^a   Butler, Georgina S ^a   Wattam, Beth A ^b   Willenbrock, Frances ^c   Williamson, Richard A ^d   Murphy, Gillian ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

AMINO TERMINAL SEQUENCE; CONFERENCE PAPER; ESCHERICHIA COLI; NONHUMAN; PROTEIN PROTEIN INTERACTION;

ESCHERICHIA COLI;

EID: 0032816129     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07716.x     Document Type: Conference Paper

References (10)

1. 1. Nagase, H., S.K. Das, S.K. Dey, J.L. Fowlkes, W. Huang & K. Brew. 1997. In Inhibitors of Metalloproteinases in Development and Disease. S.P. Hawkes, D.R. Edwards & R. Khokha, Eds. Harwood Academic Publishing. Lausanne. In press.
2. 2. Williamson, R.A., G. Martorell, M.D. Carr, G. Murphy, A.J.P. Docherty, R.B. Freedman & J. Feeney. 1994. Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family. Biochemistry 33: 11745-11759.
3. 3. Gomis-Rüth, F.-X., K. Maskos, M. Betz, A. Bergner, R. Huber, K. Suzuki, N. Yoshida, H. Nagase, K. Brew, G.P. Bourenkov, H. Bartunik & W. Bode. 1997. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature 389: 77-79.
4. 4. Muskett, F.W., T.A. Frenkiel, J. Feeney, R.B. Freedman, M.D. Carr & R.A. Williamson. 1998. High resolution structure of the N-terminal domain of Tissue Inhibitor of Metalloproteinase-2 and characterisation of its interaction site with Matrix Metalloproteinase-3. J. Biol. Chem. 273: 21736-21743.
5. 5. Fernandez-Catalan, C., W. Bode, R. Huber, D. Turk, J.J. Calvete, A. Lichte, H. Tschesche & K. Maskos. 1998. Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinase-2, the soluble progelatinase A receptor. EMBO J. 17: 5238-5248.
6. 6. Ho, S.N., H.D. Hunt, R.M. Horton, J.K. Pullen & L.R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77: 51-59.
7. 7. Williamson, R.A., D. Natalia, C.K. Gee, G. Murphy, M.D. Carr & R.B. Freedman. 1996. Chemically and conformationally authentic active domain of human tissue inhibitor of metalloproteinase-2 refolded from bacterial inclusion bodies. Eur. J. Biochem. 241: 476-483.
8. 8. Murphy, G. & F. Willenbrock. 1995. Tissue inhibitors of matrix metalloendopeptidases. Methods Enzymol. 248: 496-510.
9. 9. Willenbrock, F., T. Crabbe, P.M. Slocombe, C.W. Sutton, A.J.P. Docherty, M.I. Cockett, M. O'Shea, K. Brocklehurst, I.R. Phillips & G. Murphy. 1993. The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A. Biochemistry 32: 4330-4337.
10. 10. Nguyen, Q., F. Willenbrock, M.I. Cockett, M. O'Shea, A.J.P. Docherty & G. Murphy. 1994. Different domain interactions are involved in the binding of tissue inhibitors of metalloproteinases to stromelysin-1 and gelatinase A. Biochemistry 33: 2089-2095.