Compaction properties of composite particles consisting of lactose with sodium alginate prepared by spray-drying

Pharmaceutical Research

Volumn 16, Issue 8, 1999, Pages 1193-1198

  Takeuchi, Hirofumi ^a   Yasuji, Takehiko ^a   Hino, Tomoaki ^b   Yamamoto, Hiromitsu ^a   Kawashima, Yoshiaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Amorphous composite particle; Compaction behavior; Glass transition temperature; Interparticulate bonding; Spray drying; Tablet strength

Indexed keywords

ALGINIC ACID; LACTOSE;

ARTICLE; COMPRESSION; DRUG MANUFACTURE; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; TENSILE STRENGTH;

ALGINATES; BIOCOMPATIBLE MATERIALS; GLUCURONIC ACID; HEXURONIC ACIDS; LACTOSE; PARTICLE SIZE; POLYMERS;

EID: 0032815624     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018937227794     Document Type: Article

References (21)

1. 1. L. S. C. Wan, P. W. S. Heng, and L. F. Wong. Matrix swelling: A simple model describing extent of swelling of HPMC matrices. Int. J. Pharm. 116:159-168 (1995).
2. 2. P. Gao, J. W. Skoug, P. R. Nixon, T. R. Ju, N. L. Stemm, and K. Sung. Swelling of hydroxypropyl methylcellulose matrix tablet. 2. Mechanistic study of the influence of formulation variables on matrix performance and drug release. J. Pharm. Sci. 85:732-740 (1996).
3. 3. S. Malamataris and T. Karidas. Effect of particle size and sorbed moisture on the tensile strength of some tablets hydroxypropyl-methylcellulose (HPMC) polymers. Int. J. Pharm. 104:115-123 (1994).
4. 4. A. Nokhodchi, J. L. Ford, P. H. Rowe, and M. H. Rubinstein. The effects of compression rate and force on the compaction properties of different viscosity grades of hydroxypropylmethylcellulose 2208. Int. J. Pharm. 129:21-31 (1996).
5. 5. P. M. Belda and J. B. Mielck. The tabletting behaviour of Cellactose® compared with mixtures of cellulose with lactoses. Eur. J. Pharm. Biopharm. 42:325-330 (1996).
6. 6. P. C. Schmidt and C. J. W. Rubensdörfer. Evaluation of Ludipress as a "Multipurpose excipient" for direct compression Part I: Powder characteristics and tableting properties. Drug Dev. Ind. Pharm. 20:2899-2925 (1994).
7. 7. H. Takeuchi, T. Yasuji, T. Hino, H. Yamamoto, and Y. Kawashima. Spray-dried composite particles of lactose and sodium alginate for direct tabletting and controlled releasing. Int. J. Pharm. 174:91-100 (1998).
8. 8. W. C. Gunsel and L. Lachman. Comparative evaluation of tablet formulations prepared from conventionally-processed and spray-dried lactose. J. Pharm. Sci. 52:178-182 (1963).
9. 9. H. Vromans, G. K. Boluhuis, C. F. Lerk, K. D. Kussendrager, and H. Bosch. Studies on tableting properties of lactose. VI. Consolidation on tableting properties of spray dried lactose. Acta Pharm. Sues. 23:231-240 (1963).
10. 10. G. Buckton and P. Darcy. The use of gravimetric studies to assess the degree of crystallinity of predominantly crystalline powders. Int. J. Pharm. 123:265-271 (1995).
11. 11. J. T. Fell and J. M. Newton. Determination of tablet strength by the diametral-compression tests. J. Pharm. Sci. 221:1001-1008 (1970).
12. 12. R. W. Heckel. Density-pressure relationships in powder compaction. Trans. Met. Soc. AIME 221:671-675 (1961).
13. 13. R. W. Heckel. An analysis of powder compaction phenomena. Trans. Met. Soc. AIME 221:1001-1008 (1961).
14. 14. S. T. David and L. L. Augsburger. Plastic flow during compression of directly compressible fillers and its effect on tablet strength. J. Pharm. Sci. 66:151-159 (1977).
15. 15. J. N. Staniforth. Advances in excipient technology powder and tableting characteristics. S. T. P. Pharma. 6:162-168 (1990).
16. 16. M. Duberg and C. Nyström. Studies on direct compaction of tablets XVII. Porosity pressure curves for characterisation of volume reduction mechanisms in powder compaction. Powder Tech. 46:67-75 (1986).
17. 17. C. I. Patel and J. N. Staniforth. Determination of the apparent failure viscosity of tablets. J. Pharm. Pharmacol. 39:647-650 (1987).
18. 18. T. Sebhatu, A. A. Elamin, and C. Ahlneck. Effect of moisture sorption on tabletting characteristics of spray-dried (15% amorphous) lactose. Pharm. Res. 11:1233-1238 (1994).
19. 19. T. Sebhatu, C. Ahlneck, and G. Alderborn. The effect of moisture content on the compression and bond-formation of amorphous lactose particles. Int. J. Pharm. 146:101-114 (1997).
20. 20. H. Leuenberger and L. Ineichen. Percolation theory and physics of compression. Eur. J. Pharm. Biopharm. 44:269-272 (1997).
21. 21. J. A. Hersey, Ordered mixing: A new concept in powder mixing practice, Powder Tech. 11:41-44 (1986).