Carcinogenicity and mutagenicity of heterocyclic amines in transgenic mouse models

Cancer Letters

Volumn 143, Issue 2, 1999, Pages 245-247

  Thorgeirsson, Snorri S ^a   Ryu, Doug Young ^a   Weidner, Valerie ^a   Snyderwine, Elizabeth G ^a  

^a Laboratory of Human Carcinogenesis   (United States)

Author keywords

Carcinogenicity; Heterocyclic amines; Mutagenicity; Transgenic mouse models

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; DIETHYLNITROSAMINE; ENVIRONMENTAL CHEMICAL; EPIDERMAL GROWTH FACTOR RECEPTOR; HETEROCYCLIC AMINE; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; GENE MUTATION; LIVER CARCINOGENESIS; MOUSE; MUTAGENICITY; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; REPORTER GENE; TRANSGENIC MOUSE;

ANIMALS; DNA, COMPLEMENTARY; GENES, MYC; MICE; MICE, TRANSGENIC; MUTAGENESIS; MUTAGENS; NEOPLASMS, EXPERIMENTAL; QUINOLINES; QUINOXALINES; TRANSFORMING GROWTH FACTOR ALPHA;

MUS MUSCULUS;

EID: 0032815412     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00133-0     Document Type: Article

References (10)

1. Grisham J.W. Interspecies comparison of liver carcinogenesis: implications for cancer risk assessment. Carcinogenesis. 18:1997;5981.
2. Murakami H., Sanderson N., Nagy P., Marino P., Merlino G.T., Thorgeirsson S.S. Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor α in hepatic oncogenesis. Cancer Res. 53:1993;1719-1723.
3. SantoniRugiu E., Nagy P., Jensen M.R., Factor V.M., Thorgeirsson S.S. Evolution of neoplastic development in the liver of transgenic mice coexpressing c-myc and transforming growth factor α Am. J. Pathol. 149:1996;407-428.
4. Lee G-H., Merlino G., Fausto N. Development of liver tumors in transforming growth factor α transgenic mice. Cancer Res. 52:1992;5162-5170.
5. Sandgren E.P., Luetteke N.C., Qiu T.H., Palmiter R.D., Brinster R.L., Lee D.C. Transforming growth factor alpha dramatically enhances oncogeneinduced carcinogenesis in transgenic mouse pancreas and liver. Mol. Cell. Biol. 13:1993;320-330.
6. Amundadottir L.T., Johnson M.D., Merlino G., Smith G.H., Dickson R.B. Synergistic interaction of transforming growth factor α and c-myc in mouse mammary and salivary gland tumorigenesis. Cell Growth Diff. 6:1995;737-748.
7. Lee L.W., Raymond V.W., Tsao M-S., Lee D.C., Earp H.S., Grisham J.W. Clonal segregation of tumorigenicity with overexpression of c-myc and transforming growth factor-α genes in chemically transformed rat liver epithelial cells. Cancer Res. 51:1991;5238-5244.
8. Collins Presnell S., Thompson M.T., Strom S.C. Investigation of the cooperative effects of transforming growth factor-α and c-myc overexpression in rat liver epithelial cells. Mol. Carcinog. 13:1995;233-244.
9. Santoni-Rugiu E., Jensen M.R., Thorgeirsson S.S. Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor α Cancer Res. 58:1998;123-134.
10. Davis C.D., Dacquel E.J., Schut H.A.J., Thorgeirsson S.S., Snyderwine E.G. In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta™Mice and c-myc/lacZ double transgenic mice. Mutat. Res. 356:1996;287-296.