Anatomic localization of 24- and 96-h particle retention in canine airways

Journal of Applied Physiology

Volumn 87, Issue 1, 1999, Pages 269-284

  Kreyling, W G ^a   Blanchard, J D ^b,c   Godleski, J J ^b   Haeussermann, S ^a,d   Heyder, J ^a   Hutzler, P ^a   Schulz, H ^a   Sweeney, T D ^b,e   Takenaka, S ^a   Ziesenis, A ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c ARADIGM CORPORATION   (United States)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e GENENTECH INC   (United States)

Author keywords

Aerosol bolus inhalation; Convective gas transport; Fluorescent or radiolabeled polystyrene particles; Particle distribution in lungs; Slow particle clearance from airways

Indexed keywords

AIRWAY; ANIMAL EXPERIMENT; ARTICLE; CONFOCAL MICROSCOPY; DOG; FLUORESCENCE MICROSCOPY; INHALATION; ISOTOPE LABELING; LUNG VENTILATION; LUNG VOLUME; MORPHOMETRICS; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL;

EID: 0032814341     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.87.1.269     Document Type: Article

References (73)

1. Albert, R. E., and L. C. Arnett. Clearance of radioactive dust from the human lung. AMA Arch. Ind. Health 12: 99-106, 1955.
2. Altshuler, B., L. Yarmus, and N. Nelson. Intrapulmonary mixing of gases studied with aerosols. J. Appl. Physiol. 14: 321-327, 1959.
3. Anderson, M., K. Philipson, M. Svartengren, and P. Camner. Human deposition and clearance of 6 μm particles inhaled with an extremely low flow rate. Exp. Lung Res. 21: 187-195, 1995.
4. Bair, W. J., M. R. Bailey, F. T. Cross, R. G. Cuddihy, P. Gehr, A. C. James, J. R. Johnson, R. Masse, M. Roy, and W. Stahlhofen. Human respiratory tract model for radiological protection. ICRP Publication 66. Ann. ICRP 24: 1994.
5. Bennett, W. D., G. Scheuch, K. L. Zeman, J. S. Brown, C. Kim, J. Heyder, and W. Stahlhofen. Bronchial airway deposition and retention of particles in inhaled boli: effect of anatomic dead space. J. Appl. Physiol. 85: 685-694, 1998.
6. Cortese, D. A., J. R. Rodarte, K. Rheder, and R. E. Hyatt. Effect of posture on the single-breath oxygen test in normal subjects. J. Appl. Physiol. 41: 474-479, 1976.
7. Cuddihy, R. G., and H. C. Yeh. Respiratory tract clearance of particles and substances dissociated from particles. In: Inhalation Toxicology: the Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment, edited by U. Mohr. New York: Springer-Verlag, 1988, p. 169-193.
8. Falk, R., K. Philipson, M. Svartengren, N. Jarvis, M. B. Bailey, and P. Camner. Clearance of particles from small ciliated airways. Exp. Lung Res. 23: 495-515, 1997.
9. Fang, C. P., M. Lippman, G. Scheuch, and W. Stahlhofen. Effect of flow rate on aerosol bolus penetration in a hollow canine lung airway cast. Exp. Lung Res. 21: 547-558, 1995.
10. Ferron, G. A., F. Erbe, G. Fürst, B. Haider, J. Haller, B. Köhl, W. G. Kreyling, G. Schumann, M. Stocker, and J. Heyder. A scintillation counter for measuring removal of radio-active particles from the dog lungs. J. Aerosol Sci. 20: 1297-1300, 1989.
11. Fowler, W. S. Lung function studies. II. The respiratory dead space. Am. J. Physiol. 154: 405-416, 1948.
12. Gehr, P., B. Siegwart, and E. R. Weibel. Allometric analysis of the morphometric pulmonary diffusing capacity in dogs. J. Morphol. 168: 5-15, 1981.
13. Gehr, P., S. Schürch, Y. Berthiaume, V. Im Hof, and M. Geiser. Particle retention in airways by surfactant. J. Aerosol Med. 3: 27-43, 1990.
14. Gehr, P., V. Im Hof, M. Geiser, and S. Schürch. The fate of particles in the intrapulmonary conducting airways. J. Aerosol Med. 5: 349-362, 1992.
15. Geiser, M., V. Im Hof, P. Gehr, and L. M. Cruz-Orive. Histological and stereological analysis of particle retention in the conducting airways of hamster lungs. J. Aerosol Med. 3: 131-145, 1990.
16. Geiser, M., L. M. Cruz-Orive, V. Im Hof, and P. Gehr. Assessment of particle retention and clearance in the intrapulmonary conducting airways of hamster lungs with the fractionator. J. Microsc. 160: 75-88, 1990.
17. Haefeli-Bleuer, B., and E. R. Weibel. Morphometry of the human pulmonary acinus. Anat. Rec. 220: 401-414, 1985.
18. Heyder, J., J. D. Blanchard, H. A. Feldman, and J. D. Brain. Convective mixing in human respiratory tract: estimates with aerosol boli. J. Appl. Physiol. 64: 1273-1278, 1988.
19. Horsfield, K., and G. Cumming. Morphology of the bronchial tree in the dog. Respir. Physiol. 26: 173-182, 1976.
20. ICRP Task Group on Lung Dynamics. Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys. 12: 173-207, 1966.
21. Kreyling, W. G., G. A. Ferron, and B. Haider. Total and regional lung retention of monodisperse cobalt compound aerosols after a single inhalation. Zeitschrift für Erkranken der Atmungsorgane 164: 60-66, 1985.
22. Kreyling, W. G. Interspecies comparison of lung clearance of "insoluble" particles. J. Aerosol Med. 3: S93-S110, 1990.
23. Kreyling, W. G., G. A. Ferron, and B. Haider. Metabolic fate of inhaled CO aerosols in beagle dogs. Health Phys. 51: 773-795, 1986.
24. Kroustrup, J. P., and J. G. Gundersen. Sampling problems in a heterogeneous organ: quantitation of relative and total volume of pancreatic islets by light microscopy. J. Microsc. 132: 43-55, 1983.
25. 6 single-breath expiration curves. Comparison with the Paiva-Engel model. Bull. Eur. Physiopath. Respir. 18: 239-246, 1982.
26. Lippmann, M., and R. E. Albert. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am. Ind. Hyg. Assoc. J. 30: 257-275, 1969.
27. Mariassy, A. T. Epithelial cells of trachea and bronchi. In: Comparative Biology of the Normal Lung, edited by R. A. Parent. Boca Raton, FL: CRC, 1992, p. 63-83.
28. Meyer, M., and H. Slama. A versatile hydraulically operated respiratory servo system for ventilation and lung function testing. J. Appl. Physiol. 55: 1023-1030, 1983.
29. 6. J. Appl. Physiol. 55: 1795-1802, 1983.
30. Michel, R. P., and L. M. Cruz-Orive. Application of the Cavalieri principle and vertical sections method to lung: estimation of volume and pleural surface area. J. Microsc. 150: 117-136, 1988.
31. Möller, W., C. Roth, and W. Stahlhofen. Improved spinning top aerosol generator for the production of high concentrated ferromagnetic aerosols. J. Aerosol Sci. 21: S657-S660, 1990.
32. Morrow, P. E. Clearance kinetics of inhaled particles. In: Respiratory Defense Mechanisms Part II, edited by J. D. Brain, D. F. Proctor, and L. M. Reid. New York: Dekker, 1977, p. 491-543.
33. Morsy, S. M., E. Werner, W. Stahlhofen, and W. Pohlit. A detector of adjustable response for the study of lung clearance. Health Phys. 32: 243-251, 1977.
34. Müller, A. E., L. M. Cruz-Orive, P. Gehr, and E. R. Weibel. Comparison of two subsampling methods for electron microscopic morphometry. J. Microsc. 123: 35-49, 1981.
35. Otis, A. B., C. B. McKerrow, R. A. Bartlett, J. Mead, M. B. McIlroy, N. J. Selverstone, and E. P. Radford, Jr. Mechanical factors in distribution of pulmonary ventilation. J. Appl. Physiol. 8: 427-443, 1956.
36. Patrick, G., and C. Stirling. The retention of particles in large airways of the respiratory tract. Proc. Roy. Soc. Lond. B 198: 455-462, 1977.
37. Pavia, D. Lung mucociliary clearance. In: Aerosols and the Lung, edited by S. W. Clarke and D. Pavia. London: Butterworth, 1984, p. 127-155.
38. Rehder, K., T. J. Knopp, and A. D. Sessler. Regional intrapulmonary gas distribution in awake and anesthetized-paralyzed prone man. J. Appl. Physiol. 45: 528-535, 1978.
39. Rehder, K., and H. M. Marsh. Respiratory mechanics during anesthesia and mechanical ventilation. In: Handbook of Physiology. The Respiratory System. Mechanics of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. III, pt. 2, chapt. 43, p. 737-752.
40. Rehder, K., A. D. Sessler, and H. M. Marsh. General anesthesia and the lung. Am. Rev. Respir. Dis. 112: 541-563, 1975.
41. Rehder, K., A. D. Sessler, and J. R. Rodarte. Regional intrapulmonary gas distribution in awake and anesthetized-paralyzed man. J. Appl. Physiol. 42: 391-402, 1977.
42. 111In-labelled monodisperse polystyrene aerosol particles. J. Aerosol Sci. 20: 1289-1292, 1989.
43. Scheid, P. Respiratory mass spectrometry. In: Measurement in Clinical Respiratory Physiology, edited by G. Laszlo and M. F. Sudlow. New York: Academic, 1983, p. 131-166.
44. Scheuch, G., W. Stahlhofen, C. P. Fang, and M. Lippmann. Dispersion of aerosol particles in an airway cast of a dog. Exp. Lung Res. 21: 519-534, 1995.
45. Scheuch, G., W. Stahlhofen, and J. Heyder. An approach to deposition and clearance measurements in human airways. J. Aerosol Med. 9: 35-41, 1996.
46. Schlesinger, R. B. Clearance from the respiratory tract. Fundam. Appl. Toxicol. 5: 435-450, 1985.
47. Schroter, R. C., and M. F. Sudlow. Flow patterns in models of the human bronchial airways. Respir. Physiol. 7: 341-355, 1969.
48. Schulz, A., T. Tuch, P. Brand, H. Schulz, R. Erdl, E. von Mutius, D. Reinhardt, and J. Heyder. Aerosol bolus dispersion in the respiratory tract of children. Exp. Lung Res. 20: 119-130, 1994.
49. Schulz, H. Konvektiver und diffusiver Gastransport in der Lunge (Habilitation thesis). Munich, Germany: Ludwig-Maximillian-Universität, 1996.
50. Schulz, H., P. Heilmann, A. Hillebrecht, J. Gebhart, M. Meyer, J. Piiper, and J. Heyder. Convective and diffusive gas transport in canine intrapulmonary airways. J. Appl. Physiol. 72: 1557-1562, 1992.
51. Schulz, H., A. Schulz, and J. Heyder. Influence of intrinsic particle properties on the assessment of convective gas transport by aerosol bolus technique. Exp. Lung Res. 22: 393-407, 1996.
52. Smaldone, G. C., R. J. Perry, W. D. Bennet, M. S. Messina, J. Zwang, and J. Ilowite. Interpretation of "24 hour lung retention" in studies of mucociliary clearance. J. Aerosol Med. 1: 11-20, 1988.
53. Snipes, M. B., B. B. Boecker, and R. O. McClellan. Retention of monodisperse or polydisperse aluminosilicate particles inhaled by dogs, rats and mice. Toxicol. Appl. Pharmacol. 69: 345-362, 1983.
54. Stahlhofen, W. Human lung clearance following bolus inhalation of radioaerosols. In: Extrapolation of Dosimetric Relationships for Inhaled Particles and Gases (1st ed.), edited by J. D. Crapo, E. D. Smolko, F. J. Miller, J. A. Graham, and A. W. Hayes. San Diego, CA: Academic, 1987, p. 153-166.
55. Stahlhofen, W., J. Gebhart, and J. Heyder. Experimental determination of the regional deposition on aerosol particles in the human respiratory tract. Am. Ind. Hyg. Assoc. J. 41: 385-399, 1980.
56. Stahlhofen, W., J. Gebhart, G. Rudolf, and G. Scheuch. Measurement of lung clearance with pulses of radioactively-labeled aerosols. J. Aerosol Sci. 17: 333-336, 1986.
57. Stirling, C., and G. Patrick. The localisation of particles retained in the trachea of the rat. Pathology 131: 309-320, 1980.
58. Svartengren, K., K. Philipson, M. Svartengren, M. Anderson, and P. Camner. Tracheobronchial deposition and clearance in small airways in asthmatic subjects. Eur. Respir. J. 9: 1123-1129, 1996.
59. Sweeney, T. D., J. D. Brain, S. A. Leavitt, and J. J. Godleski. Emphysema alters the deposition pattern of inhaled particles in hamsters. Am. J. Pathol. 128: 19-28, 1987.
60. Sweeney, T. D., J. D. Brain, and S. LeMott. Anesthesia alters the pattern of aerosol retention in hamsters. J. Appl. Physiol. 54: 37-44, 1983.
61. Sweeney, T. D., J. D. Brain, A. F. Tryka, and J. J. Godleski.Retention of inhaled particles in hamsters with pulmonary fibrosis. Am. Rev. Respir. Dis. 128: 138-143, 1983.
62. Sweeney, T. D., W. A. Skornik, J. D. Brain, V. Hatch, and J. J. Godleski. Chronic bronchitis alters the pattern of aerosol deposition in lung. Am. J. Respir. Crit. Care Med. 151: 482-488, 1995.
63. Takenaka, S., G. Fuerst, P. Heilmann, A. Heini, A. Hillebrecht, A. B. Murray, and J. Heyder. An approach to unbiased sampling of pulmonary structures for morphometric analysis. J. Environ. Sci. Health B A28: 187-202, 1993.
64. Takenaka, S., G. Fürst, P. Heilmann, A. Heini, U. Heinzmann, W. G. Kreyling, A. B. Murray, L. Ruprecht, and J. Heyder. Early response of the canine respiratory tract following long-term exposure of a sulfur (IV) aerosol at low concentration. IV. Morphology and morphometry. Inhalation Toxicol. 4: 247-272, 1992.
65. Ultman, J. S. Gas transport in the conducting airways. In: Gas Mixing and Distribution in the Lung, edited by L. A. Engel and M. Paiva. New York: Dekker, 1985, p. 63-136.
66. US Environmental Protection Agency, Office of Research and Development. Air Quality Criteria for Particulate Matter. Washington, DC: Government Printing Office, 1996. (EPA/600//P-95/001cF)
67. Vries, W. R. de, and S. C. M. Luijendijk. Shape of single-breath washout curves of gases with different diffusion coefficients and blood solubilities. Bull. Eur. Physiopath. Respir. 18: 215-227, 1982.
68. Watson, A. Y., and J. D. Brain. Uptake of iron oxide aerosols by mouse airway epithelium. Lab. Invest. 40: 450-457, 1977.
69. Weibel, E. R. Morphometry of the Human Lung. Heidelberg, Germany: Springer, 1963.
70. Wolff, R. K. Mucociliary function. In: Comparative Biology of the Normal Lung, edited by B. A. Parent. Boca Baton, FL: CRC, 1992, p. 659-680.
71. Yeates, D. B. Mucus rheology. In: The Lung, Scientific Foundations, edited by R. G. Crystal and J. B. West. New York: Raven, 1991, p. 197-203.
72. Yeh, H. C., and J. R. Harkema. Gross morphometry in airways. In: Toxicoiogy of the Lung, edited by D. E. Gardner, J. D. Crapo, and R. O. McClellan. New York: Raven, 1993, p. 55-79.
73. Zeltner, T. B., T. D. Sweeney, W. A. Skornik, H. A. Feldman, and J. D. Brain. Retention and clearance of 0.9-μm particles inhaled by hamsters during rest or exercise. J. Appl. Physiol. 70: 1137-1145, 1991.