A novel zymogen granule protein (ZG29p) and the nuclear protein MTA1p are differentially expressed by alternative transcription initiation in pancreatic acinar cells of the rat

Journal of Cell Science

Volumn 112, Issue 15, 1999, Pages 2539-2548

  Kleene, Ralf ^a   Zdzieblo, Joachim ^a   Wege, Konstanze ^a   Kern, Horst Franz ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Granule formation; Nuclear protein; Rat pancreas; Transcription initiation; Zymogen granule protein

Indexed keywords

CHOLECYSTOKININ; NUCLEAR PROTEIN; POLYCLONAL ANTIBODY; ZYMOGEN GRANULE;

ACINAR CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL GRANULE; CELL NUCLEUS; DNA LIBRARY; GOLGI COMPLEX; IMMUNOFLUORESCENCE; MALE; METASTASIS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROUGH ENDOPLASMIC RETICULUM; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; AMYLASES; ANIMALS; CELL FRACTIONATION; CLONING, MOLECULAR; CYTOPLASMIC GRANULES; ENDOPLASMIC RETICULUM, ROUGH; FEMALE; GENE EXPRESSION REGULATION; GOLGI APPARATUS; HISTONE DEACETYLASES; MALE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; ORGAN SPECIFICITY; PANCREAS; PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RATS, WISTAR; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

ANIMALIA; EUKARYOTA;

EID: 0032814289     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Chen, C. Y., Cronshagen, U. and Kern, H. F. (1997). A novel pancreas-specific serpin (ZG-46p) localizes to the soluble and membrane fraction of the Golgi complex and the zymogen granules of acinar cells. Eur. J. Cell Biol. 73, 205-214.
2. Cockell, M., Stevenson, B. J., Strubin, M., Hagenbuchle, O. and Wellauer, P. K. (1989). Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas. Mol. Cell Biol. 9, 2464-2476.
3. Cronshagen, U., Voland, P. and Kern, H. F. (1994). cDNA cloning and characterization of a novel 16 kDa protein located in zymogen granules of rat pancreas and goblet cells of the gut. Eur. J. Cell Biol. 65, 366-377.
4. Dartsch, H., Kleene, R. and Kern, H. F. (1998). In vitro condensation-sorting of enzyme proteins isolated from rat pancreatic acinar cells. Eur. J. Cell Biol. 75, 211-222.
5. Davis, B. P., Hammer, R. E., Messing, A. and MacDonald, R. J. (1992). Selective expression of trypsin fusion genes in acinar cells of the pancreas and stomach of transgenic mice. J. Biol. Chem. 267, 26070-26077.
6. Feller, S. M., Ren, R., Hanafusa, H. and Baltimore, D. (1994). SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl. Trends Biochem. Sci. 19, 453-458.
7. Freedman, S. D. and Scheele, G. A. (1993). Regulated secretory proteins in the exocrine pancreas aggregate under conditions that mimic the trans-Golgi network. Biochem. Biophys. Res. Commun. 197, 992-999.
8. Huttner, W. B. and Natori, S. (1995). Regulated secretion. Helper proteins for neuroendocrine secretion. Curr. Biol. 5, 242-245.
9. Katsuyama, M., Sugimoto, Y., Okano, K., Segi, E., Ikegami, R., Negishi, M. and Ichikawa, A. (1998). Characterization of the gene for the mouse prostaglandin E receptor subtype EP2: tissue-specific initiation of transcription in the macrophage and the uterus. Biochem. J. 330, 1115-1121.
10. Kleene, R. and Berger, E. G. (1993). The molecular and cell biology of glycosyltransferases. Biochim. Biophys. Acta 1154, 283-325.
11. Kleene, R., Dartsch, H. and Kern, H. F. (1999a). The secretory lectin ZG16p mediates sorting of enzyme proteins to the zymogen granule membrane in pancreatic acinar cells. Eur. J. Cell Biol. 78, 79-80.
12. Kleene, R. Kastner, B., Rösser, R. Kern, H. F. (1999b). Complex formation among rat pancreatic secretory proteins under mild alkaline pH conditions. Digestion (in press).
13. Kleinman, H. K., McGoodwin, E. B., Rennard, S. I. and Martin, G. R. (1979). Preparation of collagen substrates for cell attachment: effect of collagen concentration and phosphate buffer. Anal. Biochem. 94, 308-312.
14. Koda, Y., Soejima, M. and Kimura, H. (1998). Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUTI) during differentiation of the human erythroid lineage. Eur. J. Biochem. 256, 379-387.
15. Krapp, A., Knofler, M., Frutiger, S., Hughes, G. J., Hagenbuchle, O. and Wellauer, P. K. (1996). The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein. EMBO J. 15, 4317-4329.
16. Kromer, A., Glombik, M. M., Huttner, W. B. and Gerdes, H. H. (1998). Essential role of the disulfide-bonded loop of chromogranin B for sorting to secretory granules is revealed by expression of a deletion mutant in the absence of endogenous granin synthesis. J. Cell Biol. 140, 1331-1346.
17. Kruse, F., Komro, C. T., Michnoff, C. H. and MacDonald, R. J. (1988). The cell-specific elastase I enhancer comprises two domains. Mol. Cell Biol. 8, 893-902.
18. Kudrycki, K. E. and Shull, G. E. (1993). Rat kidney band 3 Cl-/HCO3-exchanger mRNA is transcribed from an alternative promoter. Am. J. Physiol. 264, F540-547.
19. Kutay, U., Hartmann, E. and Rapoport, T. A. (1993). A class of membrane proteins with a C-terminal anchor. Trends Cell Biol. 3, 72-75.
20. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
21. Leblond, F. A., Viau, G., Laine, J. and Lebel, D. (1993). Reconstitution in vitro of the pH-dependent aggregation of pancreatic zymogens en route to the secretory granule: implication of GP-2. Biochem. J. 291, 289-296.
22. Lee-Kirsch, M. A., Gaudet, F., Cardoso, M. C. and Lindpaintner, K. (1999). Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ. Res. 84, 240-246.
23. Linial, M. (1994). Proline clustering in proteins from synaptic vesicles. Neuroreport 5, 2009-2015.
24. MacDonald, R. J. and Swift, G. H. (1993). Transgenic analysis of pancreatic function and development. In The Pancreas: Biology, Pathology and Disease (ed. V. L. W. Go), pp. 87-101. New York: Raven Press Ltd.
25. Mayer, B. J. and Eck, M. J. (1995). SH3 domains. Minding your p's and q's. Curr. Biol. 5, 364-367.
26. Nelson, M. and Silver, P. (1989). Context affects nuclear protein localization in Saccharomyces cerevisiae. Mol. Cell Biol. 9, 384-389.
27. Osborn, L., Rosenberg, M. P., Keller, S. A., Ting, C. N. and Meisler, M. H. (1988). Insulin response of a hybrid amylase/CAT gene in transgenic mice. J. Biol. Chem. 263, 16519-16522.
28. Rausch, U., Adler, G., Weidenbach, H., Weidenbach, F., Rudolff, D., Koop, I. and Kern, H. F. (1987a). Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor. I. Dose-response study on enzyme content and secretion, cholecystokinin release and pancreatic fine structure. Cell Tissue Res. 247, 187-193.
29. Rausch, U., Weidenbach, H., Adler, G. and Kern, H. F. (1987b). Stimulation of pancreatic secretory process in the rat by low-molecular weight proteinase inhibitor. II. Regulation of total protein and individual enzyme biosynthesis. Cell Tissue Res. 249, 63-67.
30. Roberts, B. L., Richardson, W. D. and Smith, A. E. (1987). The effect of protein context on nuclear location signal function. Cell 50, 465-475.
31. Roux, E., Strubin, M., Hagenbuchle, O. and Wellauer, P. K. (1989). The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA. Genes Dev. 3, 1613-1624.
32. Schatz, G. and Dobberstein, B. (1996). Common principles of protein translocation across membranes. Science 271, 1519-1526.
33. Scheele, G. and Kern, H. F. (1993). Cellular compartmentation, protein processing, and secretion in the exocrine pancreas. In The Pancreas: Biology, Pathobiology and Disease (ed. V. L. W. Go), pp. 121-150. New York: Raven Press Ltd.
34. Smalheiser, N. R. (1996). Proteins in unexpected locations. Mol. Biol. Cell 7, 1003-1014.
35. Sommer, L., Hagenbuchle, O., Wellauer, P. K. and Strubin, M. (1991). Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence. Cell 67, 987-994.
36. Sudol, M. (1998). From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'. Oncogene 17, 1469-1474.
37. Swarovsky, B., Steinhilber, W., Scheele, G. A. and Kern, H. F. (1988). Coupled induction of exocrine proteins and intracellular compartments involved in the secretory pathway in AR4-2J cells by glucocorticoids. Eur. J. Cell Biol. 47, 101-111.
38. Swift, G. H., Hammer, R. E., MacDonald, R. J. and Brinster, R. L. (1984). Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell 38, 639-646.
39. Thiele, C., Gerdes, H. H. and Huttner, W. B. (1997). Protein secretion: puzzling receptors. Curr. Biol. 7, R496-500.
40. Toh, Y., Pencil, S. D. and Nicolson, G. L. (1994). A novel candidate metastasis-associated gene, mtal, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses. J. Biol. Chem. 269, 22958-22963.
41. Toh, Y., Pencil, S. D. and Nicolson, G. L. (1995). Analysis of the complete sequence of the novel metastasis-associated candidate gene, mtal, differentially expressed in mammary adenocarcinoma and breast cancer cell lines. Gene 159, 97-104.
42. Toh, Y., Oki, E., Oda, S., Tokunaga, E., Ohno, S., Maehara, Y., Nicolson, G. L. and Sugimachi, K. (1997). Overexpression of the mtal 1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis. Int. J. Cancer 74, 459-463.
43. Tooze, S. A. (1998). Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells. Biochim. Biophys. Acta 1404, 231-244.
44. Wang, Z., Schultheis, P. J. and Shull, G. E. (1996). Three N-terminal variants of the AE2 Cl-/HCO3-exchanger are encoded by mRNAs transcribed from alternative promoters. J. Biol. Chem. 271, 7835-7843.
45. Yue, X., Favot, P., Dunn, T. L., Cassady, A. I. and Hume, D. A. (1993). Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation. Mol. Cell Biol. 13, 3191-3201.