Protective effect of L-carnitine on alcoholic fatty liver in rats

Medical Science Research

Volumn 27, Issue 7, 1999, Pages 475-478

  Bahcecioglu, I H ^a   Demir, A ^a   Ustundag B ^a   Ilhan, M ^a   Bayda, G ^a   Canatan, H ^a   Ozercan, I ^a  

^a FIRAT UNIVERSITY   (Turkey)

Author keywords

Alcoholic fatty liver; L carnitine; Liver damage

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTILIPEMIC AGENT; CARNITINE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; TRIACYLGLYCEROL;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY LIVER; INTRAMUSCULAR DRUG ADMINISTRATION; LIPID BLOOD LEVEL; LIPID PEROXIDATION; LIVER INJURY; MALE; NONHUMAN; RAT; STEATOSIS; TISSUE LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0032814217     PISSN: 02698951     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Eaton S, Zaitoun AM, Record CO, Bartlett K. Beta-oxidation in human alcoholic and non-alcoholic hepatic steatosis. Clin Sci 1996; 90:307-313.
2. Sherlock S, Dooley J. Alcohol and the liver. In: Diseases of the liver and Biliary System. London: Blackweli Science; 1997. pp. 385-403.
3. Batey RG, Johnston R. Effects of alcohol, carbon tetrachloride, and choline deficiency on iron metabolism in the rat. Alcohol Clin Exp Res 1993; 17:931-934.
4. Suzuki H, Tominaga T, Mizuno H, Kouno M, Suzuki M, Kalo Y, et al. Ethanol and hydrazine sulfate induced chronic hepatic injury in rats: the curative effect of administration of glucogenic amino acids. Alcohol-Alcohol 1993; 1A:I 11-117.
5. Fromenty B, Berson A, Pessayre D. Microvesiculer steatosis and steatohepatitis: Role of mitochondrial dysfunction and lipid peroxidation. Hepalology 1997; 26 (suppl. 1): 13-22.
6. Fritz IB. Action of carnitine on long chain fatty acid oxidation by liver. AmJPhysiol 1959; 197:297-307.
7. Clouet P, Sempore G, Tsoko M, Gresti J, Demarquoy J, Niot I, et al. Effect of short- and long-term treatments by a low level of dietary L-carnitine on parameters related to tatty aeid oxidation in Wistar rat. Biocliim Biophys Ada 1996; 1299:l91-lV?.
8. De Carli LM, Lieber CS. Fatty liver in the rat after prolonged intake at elhanol with a nutritionally adequate new liquid diet. J Nittr 1967: 91:331-336.
9. Yagi K. Assay of lipid peroxidation in blood plasma or serum. Metli En-ymol 1984: 105:328-363.
10. Bahcecioglu IH. Ü.stündag B, ÖJ.ercan JH. Erçel E. BaydasG. Akdere T, et ni. Protective effect of gingko biloba extract on CCl4-induced liver darnage. Hepatut Rex (in press).
11. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbutiric acid relations. Anal Biochem 1979; 95:351-358.
12. Nanji AA, Yang EK, Fogt F, Sadrazadeh SM, Dannenberg AJ. Medium chain triglycérides and vitamin E reduce the severity of established experimental alcoholic liver disease. J Pharmacol Exp Tlier 1996; 277:1694-1700.
13. Hoppel C. The physiological role of carnttine. In: Ferrari R, Diamuro S, Sherwood G (editors): L-Carnitine and its Role in Medicine: From Function to Therapy. San Diego: Academic Press Inc.; 1992. pp. 5-21.
14. Ferrari R, Diamuro S, Sherwood G, (editors): L-Carnitine and its Role in Medicine: From Function to Therapv. San Diego: Academic Press Inc.; 1992. pp. 5-21.
15. Murthy MSR. Pande SV. Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane. Proc Natl Acad Set USA 1987: 84:378-382.
16. Bieber LL, Fiol CJ. Fatty acid and ketone metabolism. Circulation 1985;72(4):9-12.
17. Bremer J. Carnitine-metabolism and functions. Physio! Rev 1983; 63:1420-1480.
18. Mondola P, Santillo M, De Mercato R, Santangeio F. The effect of Lcarnitine on cholesterol metabolism in rat (Rattus Bubalus) hepatocyte cells. Int J Biochem 1992; 24:1047-1050.
19. Bertelli A, Cerrati A, Giovannini L, Mian M, Spaggiari P, Bertelli AAE. Protective action of L-karnitine and coenzyme Q 10 against hepatic triglycéride infiltration induced by hyperbari oxygen and ethanol. Drugs Exptl Clin Res 1993; 19 (2):65-68.
20. Day CP, James OF, Brown AJ, Bennet MK, Fleming IN, Yeaman SJ. The activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings. Hepatology 1993; 18:832-838.
21. Lieber CS. Effects of ethanol upon lipid metabolism. Lipidx 1974; 9:103-116.
22. Ryle PR, Chakraborty J, Thonson AD. The effect of méthylène blue on the hepatocellular redox state and liver content during chronic ethanol feeding in the rat. Biochem J 1985; 232:877-882.
23. Ji H, Bradley TM, Tremblay GC. Atlantic Salmon (Salmo salar) fed Lcarnitine exhibit altered intermediary metabolism and reduced tissue lipid, but no change in growth rate. J Nutr 1996; 126:1937-1950.
24. Cairns SR, Peters TJ. Biochemical analysis of hepatic lipid in alcoholic and diabetic lipid and control subjects. Clin Sci 198.3; 65:645-652.
25. Mabbashi M, Sato M, Kawamura N, Imamura A, Yoshinaga K. Lipidlowering effect of carnitine in patients with type-IV hyperlipoprotenemia. Lancet 1978; i:805-807.
26. Chanda S, Mehendale HM. Role of nutrition in the survival after hepatotoxic injury. Toxicology 1996; 111:163-178.
27. Dayanandan A, Kumar P, Kalaiselvi T, Panneerselwam C. Effect of Lcarnitine on blood lipid composition in atherosclerotic rats. J Clin Biochem Nutr 1994; 17:81-87.