Elevated cAMP suppresses muscarinic inhibition of L-type calcium current in guinea pig ventricular myocytes

Journal of Cardiovascular Pharmacology

Volumn 34, Issue 2, 1999, Pages 304-315

  Sakai, Ryuta ^a,b   Shen, Jian Bing ^a   Pappano, Achilles J ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

cAMP dependent protein kinase; cGMP dependent protein kinase; Cyclic AMP; Cyclic GMP; L Type current; Protein phosphatase

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; CALCIUM ION; CARBACHOL; CYCLIC AMP; ISOBUTYLMETHYLXANTHINE; MUSCARINIC RECEPTOR; OKADAIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIC AMP BLOOD LEVEL; DOSE TIME EFFECT RELATION; GUINEA PIG; HEART MUSCLE CELL; HEART VENTRICLE; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CARBACHOL; CYCLIC AMP; CYCLIC GMP; GUINEA PIGS; MUSCARINIC AGONISTS; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE;

EID: 0032814181     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199908000-00017     Document Type: Article

References (40)

1. McDonald TF, Pelzer S, Trautwein W, Pelzer DJ. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 1994;74:365-507.
2. Pappano AJ. Modulation of the heartbeat by the vagus nerve. In: Zipes DP, Jalife J, eds. Cardiac electrophysiology: from cell to bedside. Philadelphia: WB Saunders, 1995:411-22.
3. Méry P-F, Abi-Gerge N, Vandecasteele G, Jurevicius J, Eschenhagen T, Fischmeister R. Muscarinic regulation of the L-type calcium current in isolated cardiac myocytes. Life Sci 1997;60:1113-20.
4. Hescheler J, Kameyama M, Trautwein W. On the mechanism of muscarinic inhibition of the cardiac Ca current. Pflugers Arch 1986;407:182-9.
5. 2+ current in frog ventricular myocytes. J Physiol (Lond) 1989;417:213-39.
6. Fischmeister R, Hartzell HC. Cyclic guanosine 3′5′ monophosphate regulates the calcium current in single cells from frog ventricle. J Physiol (Lond) 1987;387:453-72.
7. 2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes. Proc Natl Acad Sci USA 1991;88:1197-1201.
8. Ca by carbachol and sodium nitroprusside. Pflugers Arch 1994;426:419-26.
9. Han X, Shimoni Y, Giles WR. An obligatory role for nitric oxide in autonomic control of mammalian heart rate. J Physiol (Lond) 1994;476:309-14.
10. Rivet-Bastide M, Vandcasteele G, Hatem S, et al. cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes. J Clin Invest 1997;99: 2710-8.
11. Mubagwa K, Shirayama T, Moreau M, Pappano AJ. Effects of PDE inhibitors and carbachol on the L-type Ca current in guinea pig ventricular myocytes. Am J Physiol 1993;265:H1353-63.
12. Ahmad Z, Green F, Subuhi HS, Watanabe AM. Autonomic regulation of type 1 protein phosphatase in cardiac muscle. J Biol Chem 1989;264:3859-63.
13. Gupta RC, Neumann J, Watanabe AM. Comparison of adenosine and muscarinic receptor-mediated effects on protein phosphatase inhibitor-1 activity in the heart. J Pharmacol Exp Ther 1993;266: 16-22.
14. Gupta RC, Neumann J, Boknik P, Watanabe AM. M2-specific muscarinic cholinergic receptor-mediated inhibition of cardiac regulatory protein phosphorylation. Am J Physiol 1994;266: H1138-44.
15. Neumann J, Boknik P, Herzig S, et al. Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid. Am J Physiol 1993;265:H257-66.
16. 2+ channels. Pflugers Arch 1995; 429:531-8.
17. + current. J Gen Physiol 1990;96:195-215.
18. Cavalié A, Allen TJ, Trautwein W. Role of the GTP-binding protein Gs in the β-adrenergic modulation of cardiac Ca channels. Pflugers Arch 1991;419:433-43.
19. Haga T, Haga K, Kameyama K, Nakata H. Phosphorylation of muscarinic receptors: regulation by G proteins. Life Sci 1993;52: 421-8.
20. Corbin JD, Ogreid D, Miller JP, Suva RH, Jastroref B, Doskeland SO. Studies of cGMP analog specificity and function of the two intrasubunit binding sites of GMP-dependent protein kinase. J Biol Chem 1986;261:1208-14.
21. Schmidt MJ, Sawyer BD, Truex LL, Marshall WS, Fleisch JH. LY83583: an agent that lowers intracellular levels of cyclic guanosine 3′,5′-monophosphate. J Pharmacol Exp Ther 1985;232: 764-9.
22. Schultz C, Vaskinn S, Kildalsen H, Sager G. Cyclic AMP stimulates the cyclic GMP egression pump in human erythrocytes: effects of probenecid, verapamil, progesterone, theophylline, IBMX, forskolin and cyclic AMP on cyclic GMP uptake and association to inside-out vesicles. Biochemistry 1998;37:1161-6.
23. Kawamura A, Wahler G. Perforated-patch recording does not enhance effect of 3-isobutyl-1-methylxanthine on cardiac calcium current. Am J Physiol 1994;266:C1619-27.
24. 2+ current in rabbit atrioventricular node cells. Am J Physiol 1996;271:H2274-82.
25. Rosenbaum LC, Malencik DA, Anderson SR, Tota MR, Schimerlik MI. Phosphorylation of the porcine atrial muscarinic acetylcholine receptor by cyclic AMP dependent protein kinase. Biochemistry 1987;26:8183-8.
26. 2+ channels. Pflugers Arch 1994;428:542-51.
27. 2+ current in guinea-pig ventricular cells. J Physiol (Lond) 1991;443:387-404.
28. Shirayama T, Pappano AJ. Biphasic effects of intrapipette cyclic GMP on L-type calcium current and contraction of guinea pig ventricular myocytes. J Pharmacol Exp Ther 1996;279:1274-81.
29. Gallo MP, Alloatti G, Eva C, Oberto A, Levi RC. M1 muscarinic receptors increase calcium current and phosphoinositide turnover in guinea-pig ventricular cardiocytes. J Physiol (Lond) 1993;471: 41-60.
30. + currents in frog cardiac myocytes. Br J Pharmacol 1981;121:1369-77.
31. - cotransport by cGMP and atrial natriuretic factor. J Gen Physiol 1992;100:89-114.
32. Zakharov SI, Pieramici S, Kumar GK, Prabhakar NR, Harvey RD. Nitric oxide synthase activity in guinea pig ventricular myocytes is not involved in muscarinic inhibition of cAMP-regulated ion channels. Circ Res 1996;78:925-35.
33. Lüönd RM, McKie JH, Douglas KT. A direct link between LY83583, a selective repressor of cyclic GMP formation, and glutathione metabolism. Biochem Pharmacol 1993;45:2547-9.
34. White RE, Lee AB, Shcherbatko AD, Lincoln TM, Schonbrunn A, Armstrong DL. Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation. Nature 1993; 361:263-6.
35. 2+ current in rat ventricular cells. Circ Res 1995; 77:803-12.
36. Kelso E, McDermott BJ, Silke B. Differential effects of phosphodiesterase inhibitors on accumulation of cyclic AMP in isolated ventricular cardiomyocytes. Biochem Pharmacol 1995;49:441-52.
37. Joe EK, Shussheim AE, Longrois D, et al. Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS): mechanisms of contractile depression by nitric oxide. J Mol Cell Cardiol 1998;30:303-15.
38. Winegrad S. Regulation of cardiac contractile proteins. Circ Res 1984;55:565-74.
39. 2+ transients. Circ Res 1991;69:1369-79.
40. Hove-Madsen L, Méry P-F, Jurevisius J, Skeberdis AV, Fischmeister R. Regulation of myocardial calcium channels by cyclic AMP metabolism. Basic Res Cardiol 1996;91(suppl 2):1-8.