Oral prednisolone followed by inhaled budesonide in newly diagnosed pulmonary sarcoidosis: A double-blind, placebo-controlled multicenter study

Chest

Volumn 116, Issue 2, 1999, Pages 424-431

  Pietinalho, Anne ^a   Tukiainen, Pentti ^b   Haahtela, Tari ^b   Persson, Tore ^c   Selroos, Olof ^a,d   Kauppinen, R ^e   Koskenkari, M ^f   Kokko, E ^f   Tuomisto, L ^f   Aalto, E ^g   Jarvinen M ^h   Lillqvist, R ⁱ   Slotte, J H ⁱ   Tammivaara, R ^j   Koskinen, S ^j   Majander, R ^k   Havu, M ^l   Ahonen, A ^m   Saarelainen P , ^m   Saynajakangas O ⁿ   Kotaniemi J , ^o   Keistinen T , ^p   Rossi O , ^p   Jaakkola J , ^q   Permki E ^r   Tuominen V , ^s   Paloheimo S , ^s   Saarelma M , ^s   Venho K , ^t   Nieminen M , ^u   Palojoko A , ^v   Laurinen P , ^v   Rinne T , ^w   Lammi L , ^w   more..

^a Meltola Hospital   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c ASTRAZENECA R AND D   (Sweden)

^d Etelä Karjala Central Hospital ^*  (Sweden)

^e Etela Karjalan Keskussairaala   (Finland)

^f SOUTH OSTROBOTHNIA CENTRAL HOSPITAL   (Finland)

^g Härmä Hospital   (Finland)

^h KANTA HÄME CENTRAL HOSPITAL   (Finland)

ⁱ Keski Pohjanmaan Erikoissairaanhoito Ja Peruspalvelukuntayhtyma   (Finland)

^j Kiljava Hospital   (Finland)

^k KUOPIO UNIVERSITY HOSPITAL   (Finland)

^l KYMENLAAKSO CENTRAL HOSPITAL   (Finland)

^m Laakso Hospital   (Finland)

ⁿ LAPLAND CENTRAL HOSPITAL   (Finland)

^o Lansi Pohja Central Hospital   (Finland)

^p OULU UNIVERSITY HOSPITAL   (Finland)

^q Pietarsaari Hospital   (Finland)

^r Pohjois Karjala Central Hospital   (Finland)

^s Satalinnan Sairaala   (Finland)

^t Savonlinna Central Hospital   (Finland)

^u TAMPERE UNIVERSITY HOSPITAL   (Finland)

^v TURKU UNIVERSITY HOSPITAL   (Finland)

^w VAASA CENTRAL HOSPITAL   (Finland)

more..

Author keywords

Angiotensin converting enzyme; Budesonide; Chest radiograph; Glucocorticosteroids; Inhalation; Lung volumes; Prednisolone; Sarcoidosis

Indexed keywords

BETA 2 MICROGLOBULIN; BUDESONIDE; CARBON MONOXIDE; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE; PLACEBO; PREDNISOLONE;

ADULT; ARTICLE; CHRONIC DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ERYTHEMA NODOSUM; FEMALE; FINLAND; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FIBROSIS; LUNG VOLUME; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SARCOIDOSIS; THORAX RADIOGRAPHY;

EID: 0032813119     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.116.2.424     Document Type: Article

References (28)

1. Selroos O. The frequency, clinical picture and prognosis of pulmonary sarcoidosis in Finland. Acta Med Scand 1969; 503(suppl):1-73
2. Siltzbach LE, James DG, Neville E, et al. Course and prognosis of sarcoidosis around the world. Am J Med 1974; 57:847-852
3. Löfgren S. Primary pulmonary sarcoidosis: II. Clinical course and prognosis. Acta Med Scand 1953; 145:465-474
4. Hannuksela M, Salo OP, Mustakallio KK. The prognosis of acute untreated sarcoidosis. Ann Clin Res 1970; 2:57-61
5. Neville E, Walker AN, James DG. Prognostic factors predicting the outcome of sarcoidosis: An analysis of 818 patients. Q J Med 1983; 208:525-533
6. Tukiainen P, Taskinen E, Riska H. The prognostic value of bronchoalveolar lavage in sarcoidosis. Sarcoidosis 1994; 11:69-72
7. DeRemee RA, Offord KP. The treatment of pulmonary sarcoidosis: The house revisited. Sarcoidosis 1992; 9(suppl 1):17-29
8. Hunninghake GW, Gilbert S, Pueringer R, et al. Outcome of the treatment for sarcoidosis. Am J Respir Crit Care Med 1994; 149:893-898
9. Gibson GJ, Prescott RJ, Muers MF, et al. British Thoracic Society sarcoidosis study: Effects of long term corticosteroid treatment. Thorax 1996; 51:238-247
10. Selroos O. Glucocorticosteroids and pulmonary sarcoidosis. Thorax 1996; 51:229-230
11. Grönhagen-Riska C, Selroos O, Niemistö M. Angiotensin converting enzyme: V. Serum levels as monitors of disease activity in corticosteroid-treated sarcoidosis. Eur J Respir Dis 1980; 61:113-122
12. Baughman RP, Shipley R, Eisentrout CE. Predictive value of gallium scan, angiotensin-converting enzyme level, and bronchoalveolar lavage in two-year follow-up of pulmonary sarcoidosis. Lung 1987; 165:371-377
13. Scadding M, Mitchell DN. Sarcoidosis. London, UK: Chapman and Hall, 1985; 578-598
14. Barnes PJ, Pedersen S. Efficacy and safety of inhaled corticosteroids in asthma [review]. Am Rev Respir Dis 1993; 148:S1-S26
15. Selroos O. Use of budesonide in the treatment of pulmonary sarcoidosis. Ann N Y Acad Sci 1986; 465:713-721
16. Selroos O, Löfroos AB, Pietinalho A, et al. Inhaled budesonide for maintenance treatment of pulmonary sarcoidosis. Sarcoidosis 1994; 11:126-131
17. Zych D, Pawlicka L, Zielinski J. Inhaled budesonide vs prednisone in the maintenance treatment of pulmonary sarcoidosis. Sarcoidosis 1993; 10:56-61
18. Alberts C, van der Mark TW, Jansen HM. Inhaled budesonide in pulmonary sarcoidosis: A double-blind, placebo-controlled study. Eur Respir J 1995; 5:682-688
19. Erkkilä S, Fröseth B, Hellström PE, et al. Inhaled budesonide influences cellular and biochemical abnormalities in pulmonary sarcoidosis. Sarcoidosis 1988; 5:106-110
20. Spiteri MA, Newman SP, Clarke SW, et al. Inhaled corticosteroids can modulate the immunopathogenesis of pulmonary sarcoidosis. Eur Respir J 1989; 2:218-224
21. Ryrfeldt Å, Persson G, Nilsson E. Pulmonary disposition of the potent glucocorticoid budesonide, evaluated in an isolated perfused rat lung model. Biochem Pharmacol 1989; 38:17-22
22. Van den Bosch JM, Westermann CJ, Aumann J, et al. Relationship between lung tissue and blood plasma concentrations of inhaled budesonide. Biopharm Drug Dispos 1993; 14:455-459
23. Selroos O, Niemistö M, Riska N. A follow-up of treated and untreated early pulmonary sarcoidosis. In: Iwai K, Hosoda Y, eds. Proceedings of the VI International Conference on Sarcoidosis. Tokyo, Japan: University of Tokyo Press, 1973:525-528
24. Selroos O. Use of budesonide in the treatment of pulmonary sarcoidosis. In: Ellul-Micallef R, Lam WK, Toogood JH, eds. Advances in the Use of Inhaled Corticosteroids. Hong Kong: Exerpta Medica, 1987:188-197
25. Morgan AD, Johnson MA, Kerr I, et al. The action of an inhaled corticosteroid as a steroid sparing agent in chronic pulmonary sarcoidosis [abstract]. Am Rev Respir Dis 1987; 135:A349
26. Milman N, Graudal N, Grode G, et al. No effect of high-dose inhaled steroids in pulmonary sarcoidosis: A double-blind, placebo-controlled study. J Intern Med 1994; 236:285-290
27. Thorsson L, Edsbäcker S, Conradson TB. Lung deposition of budesonide from Turbuhaler is twice that from a pressurized metered dose inhaler P-MDI. Eur Respir J 1994; 7:1839-1844
28. Johansson SÅ, Andersson KE, Brattsand R, et al. Topical and systemic glucocorticoid potencies of budesonide, beclomethasone dipropionate and prednisolone in man. Eur J Respir Dis Suppl 1982; 122:74-82