Culture-independent prediction of isoniazid resistance in Mycobacterium tuberculosis by katG gene analysis directly from sputum samples

Molecular Diagnosis

Volumn 4, Issue 2, 1999, Pages 145-152

  Rinder, Heinz ^a   Feldmann, Knut ^b   Tortoli, Enrico ^d   Grosset, Jacques ^e   Casal, Manuel ^f   Richter, Elvira ^c   Rifai, Mohammed ^b   Jarlier, Vincent ^e   Vaquero, Manuel ^f   Rüsch Gerdes, Sabine ^c   Cambau, Emmanuelle ^e   Gutierrez, Juan ^f   Löscher, Thomas ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b ASKLEPIOS FACHKLINIKEN MÜNCHEN GAUTING   (Germany)

^c National Reference Center for Mycobacteria   (Germany)

^d CAREGGI UNIVERSITY HOSPITAL   (Italy)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

Genotyping; Heteroresistance; PCR RFLP

Indexed keywords

ISONIAZID;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; BACTERIUM IDENTIFICATION; GENE SEQUENCE; GENOTYPE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; SEQUENCE ANALYSIS; SPUTUM CULTURE;

EID: 0032812660     PISSN: 10848592     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1084-8592(99)80038-1     Document Type: Article

References (3)

1. Heym B, Alzari PM, Honoré N, Cole ST: Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol 1995;15:235-245
2. Musser JM, Kapur V, Williams DL, Kreiswirth BN, van Soolingen D, van Embden JDA: Characterization of the catalase-peroxidase gene (katG) and inliA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: restricted array of mutations associated with drug resistance. J Infect Dis 1996;173:196-202
3. Morris S, Bai GH, Suffys P, Portillo-Gomez L, Fairchok M, Rouse D: Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis. J Infect Dis 1995;171:954-960