Stereoselective synthesis of a conformationally defined cyclohexyl carnitine analogue that binds CPT-1 with high affinity

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 8, 1999, Pages 1505-1511

  Hutchison, Tracy L ^a   Saeed, Ashraf ^a   Wolkowicz, Paul E ^a   McMillin, Jeanie B ^b   Brouillette, Wayne J ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Carnitine; Carnitine acyltransferase; Conformationally defined analogue; Cound conformation; Enzyme inhibition

Indexed keywords

CARNITINE ACYLTRANSFERASE; CARNITINE DERIVATIVE; ENZYME INHIBITOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG SYNTHESIS; ENZYME KINETICS; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PIGEON; RAT; STEREOSPECIFICITY;

ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; CELLS, CULTURED; COLUMBIDAE; CYCLOHEXANECARBOXYLIC ACIDS; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; QUATERNARY AMMONIUM COMPOUNDS; RATS;

EID: 0032811374     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00080-2     Document Type: Article

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