Synthesis of substituted indole-2-carboxylates: Versatile introduction of a carbamoyl moiety at the C-3 position

Synthetic Communications

Volumn 29, Issue 18, 1999, Pages 3125-3135

  Giacobbe, Simone A ^a,b   Di Fabio, Romano ^a   Baraldi, Davide ^a   Cugola, Alfredo ^a   Donati, Daniele ^a  

^a GSK   (Italy)

^b EUROPEAN PATENT OFFICE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 INDOLECARBOXYLIC ACID; 2 INDOLECARBOXYLIC ACID DERIVATIVE; 4,6 DICHLORO 3 PHENYLCARBAMOYLETHYNYLINDOLE 2 CARBOXYLIC ACID; GAVESTINEL; GLYCINE; ISOCYANIC ACID DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING SITE; DRUG SYNTHESIS; NEUROPROTECTION; PROTON NUCLEAR MAGNETIC RESONANCE; STROKE;

EID: 0032811211     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919908085936     Document Type: Article

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28. The fact that LiOH is able to eliminate HC1 across the double bond came as a surprise. Studies are under way to clarify the mechanism of this unusual reaction, but we believe that the indole nitrogen should play a pivotal role. The results of these studies will be published in due course.
29. 6,8 = 2 Hz.