One-step synthesis of novel 2,4-diaminopyrimidine antifolates from bridged alicyclic ketones and cyanoguanidine

Journal of Heterocyclic Chemistry

Volumn 36, Issue 3, 1999, Pages 723-728

  Rosowsky, Andre ^a   Papoulis, Andrew T ^a   Queener, Sherry F ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; 3,5 DIAMINO 4,6 DIAZATRICYCLO[6.2.1.0]UNDECA 2,4,6 TRIENE; 4,6 DIAMINO 3,5 DIAZATRICYCLO[7.2.1.0]DODECA 2,4,6 TRIENE; DIHYDROFOLATE REDUCTASE INHIBITOR; GUANIDINE DERIVATIVE; KETONE DERIVATIVE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; CHEMICAL BOND; CHEMICAL REACTION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; NONHUMAN; POLYMERIZATION; REACTION ANALYSIS; STEREOSPECIFICITY;

EID: 0032810965     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570360324     Document Type: Article

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