Genetic abnormalities in polycystic ovary syndrome

Annales d'Endocrinologie

Volumn 60, Issue 2, 1999, Pages 131-133

  Franks, S ^a   Gharani, N ^a   Mccarthy, M ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA MINISATELLITE;

ALLELE; ARTICLE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; MOLECULAR GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY POLYCYSTIC DISEASE;

CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; INSULIN; MINISATELLITE REPEATS; POLYCYSTIC OVARY SYNDROME; STEROID 17-ALPHA-HYDROXYLASE;

EID: 0032810832     PISSN: 00034266     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. DAHLGREN E, JOHANSSON S, LINDSTEDT G et al. Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones. Fertil Steril 1992; 57(3): 505-13.
2. DUNAIF A. Insulin resistance and polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews 1997; 18: 774-800.
3. FRANKS S. Medical Progress Article: Polycystic ovary syndrome. New England Journal of Medicine 1995; 33: 853-861.
4. FRANKS S. The 17a-hydroxylase-17, 20-lyase gene (CYP17) and polycystic ovary syndrome. (Commentary) Clinical Endocrinology 1997; 46: 135-136.
5. FRANKS S, GHARANI N, WATERWORTH D, et al. The genetic basis of polycystic ovary syndrome. Human Reproduction 1997; 12: 2641-2648.
6. GHARANI N, WATERWORTH DM, BATTY S et al. Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism. Human Molecular Genetics 1997; 6: 397-402.
7. HOLTE J, BERGH T, BERNE C et al. Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 1995; 80: 2586-2593.
8. KRUGLYAK L, DALY MJ, REEVE-DALY MP et al. Parametric and non-parametric linkage analysis: a unified multipoint approach. American Journal of Human Genetics 1996; 58: 1347-1363.
9. LEGRO RS. The genetics of polycystic ovary syndrome. American Journal of Medicine 1995; 98: suppl 1A, 9S-16S.
10. ROBINSON S, KIDDY D, GELDING SV et al. The relationship of insulin sensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clinical Endocrinology 1993; 39: 351-355.
11. ROSHNFIELD RL, BARNES RB, CARA JF, LUCKY AW. Dysregulation of cytochrome P450c17 alpha as the cause of polycystic ovarian syndrome. Fertility and Sterility 1990; 53: 785-91.
12. SIMPSON JL. Elucidating the genetics of polycystic ovary syndrome. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic ovary syndrome. Oxford: Blackwell Scientific Publications 1992; pp. 59-77.
13. WATERWORTH DM, BENNETT ST, GHARANI N et al. Linkage and association of the insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet 1997; 349: 986-90.