N-acetylcysteine fails to protect rats from acrylamide neurotoxicity

Journal of Occupational Health

Volumn 41, Issue 3, 1999, Pages 181-182

  Wispriyono, Bambang ^a   Iryo, Yoshihisa ^a   Yoshida, Tohko ^a   Matsuoka, Masato ^a   Igisu, Hideki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Acrylamide; Ataxia; Glutathione; Landing foot spread; N acetylcysteine; Neurotoxicity; Rat

Indexed keywords

ACETYLCYSTEINE; ACRYLAMIDE; GLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; BRAIN PROTECTION; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MUSCLE WEAKNESS; NEUROTOXICITY; NONHUMAN; RAT;

ANIMALIA; ATAXIA;

EID: 0032809961     PISSN: 13419145     EISSN: None     Source Type: Journal    
DOI: 10.1539/joh.41.181     Document Type: Article

References (14)

1. Igisu H, Goto I, Kawamura Y, Kato M, Izumi K, Kuroiwa Y. Acrylamide encephaloneuropathy due to well water pollution. J Neurol Neurosurg Psychiatry 1975; 38: 581-584.
2. Hashimoto K, Aldridge WN. Biochemical studies on acrylamide, a neurotoxic agent. Biochem Pharmacol 1970; 19: 2591-2604.
3. Flanagan RJ, Meredith TJ. Use of N-acetylcysteine in clinical toxicology. Am J Med 1991; 91: 131s-139s.
4. Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989; 6: 593-597.
5. Cotgreave IA. N-Acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol 1997; 38: 205-227.
6. Ferrari G, Yan CYI, Greene LA. N-Acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 1995; 15: 2857-2866.
7. Knuckey NW, Palm D, Primiano M, Epstein MH, Johanson CE. N-Acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats. Stroke 1995; 26: 305-311.
8. Henderson JT, Javaheri M, Kopko S, Roder JC. Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-L-cystcine. J Neurosci 1996; 16: 7574-7582.
9. Edwards PM, Parker VH. A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats. Toxicol Appl Pharmacol 1977; 40: 589-591.
10. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem, 1968; 25: 192-205.
11. Benz FW, Nerland DE, Pierce WM, Babiuk C. Acute acrylonitrile toxicity: studies on the mechanism of the antidotal effect of D-and L-cysteine and their N-acetyl derivatives in the rat. Toxicol Appl Pharmacol 1990; 102: 142-150.
12. Matsuoka M, Matsumura H, Igisu H. Creatine kinase activities in brain and blood: possible neurotoxic indicator of acrylamide intoxication. Occup Environ Med 1996; 53: 468-471.
13. van Klaveren RJ, Dinsdale D, Pype JL, Demedts M, Nemery B. N-Acetylcysteine does not protect against type II cell injury after prolonged exposure to hyperoxia in rats. Am J Physiol 1997; 273: L548-L555.
14. Wispriyono B, Matsuoka M, Igisu H, Matsuno K. Protection from cadmium cytotoxicity by N-acetylcysteine in LLC-PK, cells. J Pharmacol Exp Ther 1998; 287: 344-351.