Characterization of monoclonal antibodies to an immunodominant protein of the etiologic agent of human granulocytic ehrlichiosis

American Journal of Tropical Medicine and Hygiene

Volumn 61, Issue 1, 1999, Pages 171-176

  Ravyn, M Dana ^a   Lamb, Lana J ^a   Jemmerson, Ronald ^a   Goodman, Jesse L ^b   Johnson, Russell C ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; EPITOPE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G3; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COXIELLA BURNETII; EHRLICHIA; EHRLICHIA CHAFFEENSIS; EHRLICHIOSIS; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; RICKETTSIA PROWAZEKII; RICKETTSIA RICKETTSII;

EID: 0032809503     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.1999.61.171     Document Type: Article

References (21)

1. Bakken JS, Dumler JS, Chen SM, Eckman MR, Van Etta LL, Walker DH, 1994. Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? JAMA 272: 212-218.
2. Bakken JS, Krueth J, Wilson-Nordskog C, Tilden RL, Asanovich K, Dumler JS, 1996. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 275: 199-205.
3. Chen SM, Dumler JS, Bakken JS, Walker DH, 1994. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J Clin Microbiol 32: 589-595.
4. Dumler JS, Asanovich KM, Bakken JS, Richter P, Kimsey R, Madigan JE, 1995. Serologic cross-reactions among Ehrlichia equi, Ehrlichia phagocytophila, and human granulocytic Ehrlichia. J Clin Microbiol 33: 1098-1103.
5. Aguero-Rosenfeld ME, Horowitz HW, Wormser GP, McKenna DF, Nowakowski J, Munoz J, Dumler JS, 1996. Human granulocytic ehrlichiosis: a case series from a medical center in New York State. Ann Intern Med 125: 904-908.
6. Pancholi P, Kolbert CP, Mitchell KD, Reed JS, Dumler JS, Bakken JS, Telford III SR, Persing DH, 1995. Ixodes dammini as a potential vector of human granulocytic ehrlichiosis. Clin Infect Dis 172: 1007-1012.
7. Telford III SR, Dawson JE, Katavolos P, Warner CK, Kolbert CP, Persing DH, 1996. Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proc Natl Acad Sci USA 93: 6209-6214.
8. Parola P, Beati L, Cambon M, Brouqui P, Raoult D, 1998. Ehrlichial DNA amplified from Ixodes ricinus (Acari: Ixodidae) in France. J Med Entomol 35: 180-183.
9. Asanovich KM, Bakken JS, Madigan JE, Aguero-Rosenfeld M, Wormser GP, Dumler JS, 1997. Antigenic diversity of granulocytic Ehrlichia isolates from humans in Wisconsin and New York and a horse in California. J Infect Dis 176: 1029-1034.
10. IJdo JW, Zhang Y, Hodzic E, Magnarelli LA, Wilson ML, Telford SR, Barthold SW, Fikrig E, 1997. The early humoral response in human granulocytic ehrlichiosis. J Infect Dis 176: 687-692.
11. Ravyn MD, Goodman JL, Kodner CB, Westad DK, Coleman LA, Engstrom SM, Nelson CM, Johnson RC, 1998. Immunodiagnosis of human granulocytic ehrlichiosis by using culture-derived human isolates. J Clin Microbiol 36: 1480-1488.
12. Wong SJ, Brady GS, Dumler JS, 1997. Serological responses to Ehrlichia equi, Ehrlichia chaffeensis, and Borrelia burgdorferi in patients from New York State. J Clin Microbiol 35: 2198-2205.
13. Zhi N, Rikihisa Y, Kim HY, Wormser GP, Horowitz HW, 1997. Comparison of major antigenic proteins of six strains of the human granulocytic ehrlichiosis agent by Western immunoblot analysis. J Clin Microbiol 35: 2606-2611.
14. Zhi N, Ohashi N, Rikihisa Y, Horowitz HW, Wormser GP, Hechemy K, 1998. Cloning and expression of the 44-kilodalton major outer membrane protein gene of the human granulocytic ehrlichiosis agent and application of the recombinant protein to serodiagnosis. J Clin Microbiol 36: 1666-1673.
15. Engstrom SM, Shoop E, Johnson RC, 1995. Immunoblot interpretation criteria for serodiagnosis of early Lyme disease. J Clin Microbiol 33: 419-427.
16. Johnson RC, Johnson BJB, 1997. Lyme disease: Serodiagnosis of Borrelia burgdorferi sensu lato infection. Rose HR, ed. Manual of Clinical Laboratory Immunology. Fifth Edition. Washington, DC: American Society for Microbiology, 526-533.
17. Kim H-Y, Rikihisa Y, 1998. Characterization of monoclonal antibodies to the 44-kilodalton major outer surface protein of the human granulocytic ehrlichiosis agent. J Clin Microbiool 36: 3278-3284.
18. Goodman JL, Nelson C, Vitale JE, Madigan JE, Dumler JS, Kurtti TJ, Munderloh UG, 1996. Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N Engl J Med 334: 209-215.
19. Friguet B, Djavadi-Ohaniance, Pages J, Bussard A, Goldberg M, 1983. A convenient enzyme linked immunosorbent assay for testing whether monoclonal antibodies recognize the same antigenic site. J Immunol Methods 60: 351-358.
20. Laemmli UK, 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
21. Ehrlich PH, Moyle WR, Moustafa ZA, Canfield CE, 1982. Mixing two monoclonal antibodies yields enhanced affinity for antigen. J Immunol 128: 2709-2713.