NPY inhibits glutamatergic excitation in the epileptic human dentate gyrus

Journal of Neurophysiology

Volumn 82, Issue 1, 1999, Pages 478-483

  Patrylo, Peter R ^a   Van Den Pol, Anthony N ^a   Spencer, Dennis D ^a   Williamson, Anne ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METABOTROPIC RECEPTOR;

ARTICLE; BRAIN SLICE; DENTATE GYRUS; ELECTROENCEPHALOGRAM; EPILEPSY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; NEUROTRANSMISSION; PRIORITY JOURNAL; SEIZURE;

EID: 0032808165     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1999.82.1.478     Document Type: Article

References (31)

1. BABB, T. L., KUPFER, W. R., PRETORIUS, J. K., CRANDALL, P. H., AND LEVESQUE, M. F. Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience 42: 351-363, 1991.
2. BARABAN S. C., HOLLOPETER, G., ERICKSON, J. C., SCHWARTZKROIN, P. A., AND PALMITER, R. D. Knock-out mice reveal a critical antiepileptic role for neuropeptide Y. J. Neurosci. 17: 8927-8936, 1997.
3. BLEAKMAN, D., HARRISON, N. L., COLMERS, W. F., AND MILLER, R. J. Investigations into neuropeptide Y-mediated presynaptic inhibition in cultured hippocampal neurones of the rat. Br. J. Pharmacol. 107: 334-340, 1992.
4. CHRONWALL, B., DIMAGGIO, D., MASSARI, V., PICKEL, V., RUGGIERO, D., AND O'DONOHUE, T. The anatomy of neuropeptide Y containing neurons in the rat brain. Neuroscience 15: 1159-1181, 1985.
5. COLMERS, W., LUKOWIAK, K., AND PITTMAN, Q. Neuropeptide Y action in the rat hippocampal slice: site and mechanism of presynaptic inhibition. J. Neurosci. 8: 3827-3837, 1988.
6. CSIFFARY, A., GORCS, T., AND PALKOVITS, M. Neuropeptide Y innervation of ACTH-immunoreactive neurons in the arcuate nucleus of rats: a correlated light and electron microscopic double immunolabeling study. Brain Res. 506: 215-222, 1990.
7. DE LANEROLLE, N. C., KIM, J. H., WILLIAMSON, A., PHILIPS, M. F., AND SPENCER, D. D. Neurochemical remodelling of the hippocampus in human temporal lobe epilepsy. Mol. Neurobiol. Epilepsy Res. Suppl. 9: 205-220, 1992.
8. DUDEK, F. E., OBENAUS, A., SCHWEITZER, J. S., AND WUARIN, J. P. Functional significance of hippocampal plasticity in epileptic brain: electrophysiological changes of the dentate granule cells associated with mossy fiber sprouting. Hippocampus 4: 259-265, 1994.
9. DUMONT, Y., JACQUES, D., BOUCHARD, P., AND QUIRION, R. Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains. J. Comp. Neurol. 402: 372-384, 1998.
10. GEREAU, R. W. AND CONN, P. J. Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1. J. Neurosci. 15: 6879-6889, 1995.
11. GRUBER, B., GREBER, S., RUPP, E., AND SPERK, G. Differential NPY mRNA expression in granule cells and interneurons of the rat dentate gyrus after kainic acid injections. Hippocampus 4: 474-482, 1994.
12. HÖKFELT, T. Neuropeptides in perspective: the last ten years. Neuron 7: 867-879, 1991.
13. HOUSER, C. R., MIYASHIRO, J. E., SWARTZ, B. E., WALSH, G. O., RICH, J. R., AND DELGADO-ESCUETA, A. V. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. J. Neurosci. 10: 267-282, 1990.
14. KLAPSTEIN, G. J. AND COLMERS, W. F. On the sites of presynaptic inhibition by neuropeptide Y in rat hippocampus in vitro. Hippocampus 3: 103-112, 1993.
15. KLAPSTEIN, G. J. AND COLMERS, W. F. Neuropeptide Y suppresses epileptiform activity in rat hippocampus in vitro. J. Neurophysiol. 78: 1651-1661, 1997.
16. MACEK, T. A., WINDER, D. G., GEREAU, R., LADD, C. O., AND CONN, P. J. Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses. J. Neurophysiol. 76: 3798-3806, 1996.
17. MARKSTEINER, J., ORTLER, M., BELLMANN, R., AND SPERK, G. Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat. Neurosci. Lett. 112: 143-148, 1990.
18. MATHERN, G. W., BABB, T. L., PRETORIUS, J. K., AND LEITE, J. P. Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. J. Neurosci. 15: 3990-4004, 1995.
19. MCQUISTON, A. R., PETROZZINO, J. J., CONNOR, J. A., AND COLMERS, W. F. Neuropeptide Y1 receptors inhibit N-type calcium currents and reduce transient calcium increases in dentate granule cells. J. Neurosci. 16: 1422-1429, 1995.
20. OBRIETAN, K. AND VAN DEN POL, A. N. NPY depresses GABA-mediated calcium transients in developing SCN neurons: a novel form of calcium long term depression. J. Neurosci. 16: 3521-3533, 1996.
21. PATRYLO, P. R. AND DUDEK, F. E. Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats. J. Neurophysiol. 79: 418-429, 1998.
22. PICKEL, V. M., CHAN, J., VEZNEDAROGLU, E., AND MILNER, T. A. Neuropeptide Y and dynorphin-immunoreactive large dense-core vesicles are strategically localized for presynaptic modulation in the hippocampal formation and substantia nigra. Synapse 9: 160-169 1995.
23. SCHWARZER, C., KOFLER, N., AND SPERK, G. Up-regulation of neuropeptide Y-Y2 receptors in an animal model of temporal lobe epilepsy. Mol. Pharmacol. 53: 6-13, 1998.
24. SPENCER, S. S., SO, N. K., ENGEL, J., JR. AND SPENCER, D. D. Depth electrodes. In: Surgical Treatment of the Epilepsies (2nd ed.), edited by J. Engel, Jr. New York: Raven, 1993, p. 359-376.
25. SPERK, G., MARKSTEINER, B., GRUBER, B., BELLMANN, R., MAHATA, M., AND ORTLER, M. Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat. Neuroscience 50: 831-846, 1992.
26. SUTULA, T., CASCINO, G., CAVAZOS, J., PARADA, I., AND RAMIREZ, L. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann. Neurol. 26: 321-330, 1989.
27. VAN DEN POL, A. N. GABA immunoreactivity in hypothalamic neurons and growth cones in early development in vitro prior to synapse formation. J. Comp. Neurol. 383: 178-188, 1997.
28. VAN DEN POL, A. N., OBRIETAN, K., CHEN, G., AND BELOUSOV, A. NPY modulation of glutamate actions. J. Neurosci. 16: 5883-5895, 1996.
29. WILLIAMSON, A. Electrophysiology of epileptic human neocortical and hippocampal neurons maintained in vitro. Clin. Neurosci. 2: 47-52, 1994.
30. WILLLAMSON, A., SPENCER, S. S., AND SPENCER, D. D. Correlation between depth electrode studies and intracellular granule cell recordings in patients with temporal lobe epilepsy. Ann. Neurol. 38: 778-787, 1995.
31. WOLDBYE, D.P.D, LARSEN, P. J., MIKKELSEN, J. D., KLEMP, K., MADSEN, T. M., AND BOLWIG, T. G. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. Nature Med. 3: 761-764, 1997.