Mice with a targeted intronic deletion in the Col1a1 gene respond to bleomycin-induced pulmonary fibrosis with increased expression of the mutant allele

Matrix Biology

Volumn 18, Issue 3, 1999, Pages 287-294

  Hormuzdi, Sheriar G ^a   Strandjord, Thomas P ^a   Madtes, David K ^b   Bornstein, Paul ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CIS ACTING ELEMENT; COLLAGEN TYPE 1;

ALLELE; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE SEQUENCE; INTRON; LUNG FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALLELES; ANIMALS; BLEOMYCIN; COLLAGEN; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; INTRONS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PULMONARY FIBROSIS;

EID: 0032808003     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0945-053X(99)00017-7     Document Type: Article

References (35)

1. Bornstein P. Regulation of expression of the α1(I) collagen gene: A critical appraisal of the role of the first intron. Matrix Biol. 15:1996;3-10.
2. Bornstein P., Sage H. Regulation of collagen gene expression. Prog. Nucl. Acid Res. Mol. Biol. 37:1989;66-106.
3. Bou-Gharios G., Garrett L.A., Rossert J.et al. A potent far-upstream enhancer in the mouse proα2(I) collagen gene regulates expression of reporter genes in transgenic mice. J. Cell Biol. 134:1996;1333-1344.
4. Breault D.T., Lichtler A.C., Rowe D.W. COL1A1 transgene expression in stably transfected osteoblastic cells: Relative contributions of first intron, 3′-flanking sequences, and sequences derived from the body of the human COL1A1 minigene. J. Biol. Chem. 272:1997;31241-31250.
5. Brinster R.L., Allen J.M., Behringer R.R., Gelinas R.E., Palmiter R.D. Introns increase transcriptional efficiency in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 85:1988;836-840.
6. Brown R.F., Drawbaugh R.B., Marrs T.C. An investigation of possible models for the production of progressive pulmonary fibrosis in the rat. The effects of repeated intratracheal instillation of bleomycin. Toxicology. 51:1988;101-110.
7. Chen S., Artlett C.M., Jimenez S.A., Varga J. Modulation of human α1(I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro. Gene. 215:1998;101-110.
8. Garnero P., Borel O., Grant S.F.A., Ralston S.H., Delmas P.D. Collagen Iα1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: The OFELY study. J. Bone Miner. Res. 13:1998;813-817.
9. Greenwel P., Inagaki Y., Hu W., Walsh M., Ramirez F. Sp1 is required for the early response of alpha 2(I) collagen to transforming growth factor-beta 1. J. Biol. Chem. 272(2):1997;19738-19745.
10. Hormuzdi S.G., Penttinen R., Jaenisch R., Bornstein P. A gene-targeting approach identifies a function for the first intron in expression of the α1(I) collagen. Mol. Cell. Biol. 18:1998;3368-3375.
11. Hoyt D.G., Lazo J.S. Alterations in pulmonary messenger RNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice. J. Pharmacol. Exp. Ther. 246:1988;765-771.
12. Ihn H., Trojanowska M. Sp3 is a transcriptional activator of the human alpha 2(I) collagen gene. Nucl. Acids Res. 25(4):1997;3712-3717.
13. Koh D.W., Roby J.D., Starcher B., Senior R.M., Pierce R.A. Postpneumonectomy lung growth: A model of reinitiation of tropoelastin and type I collagen production in a normal pattern in adult rat lung. Am. J. Respir. Cell Mol. Biol. 15:1996;611-623.
14. Koslowski R., Knoch K., Wenzel K. Proteinases and proteinase inhibitors during the development of pulmonary fibrosis in rat. Clin. Chim. Acta. 271:1998;45-56.
15. Langdahl B.L., Ralston S.H., Grant S.F.A., Eriksen E.F. An Sp1 binding site polymorphism in the COL1A1 gene predicts osteoporotic fractures in men and women. J. Bone Miner. Res. 13:1998;1384-1389.
16. Lazenby A.J., Crouch E.C., McDonald J.A., Kuhn C. Remodeling of the lung in bleomycin-induced pulmonary fibrosis in the rat - an immunohistochemical study of laminin, type-IV collagen, and fibronectin. Am. Rev. Resp. Dis. 142:1990;206-214.
17. Liska D.J., Reed M.J., Sage E.H., Bornstein P. Cell-specific expression of α1(I) collagen-hGH minigenes in transgenic mice. J. Cell Biol. 125:1994;695-704.
18. Palmiter R.D., Sandgren E.P., Avarbock M.R., Allen D.D., Brinster R.L. Heterologous introns can enhance expression of transgenes in mice. Proc. Natl. Acad. Sci U.S.A. 88:1991;478-482.
19. Phan S.H., Thrall R.S., Williams C. Bleomycin-induced pulmonary fibrosis - effects of steroid on lung collagen metabolism. Am. Rev. Resp. Dis. 124:1981;428-434.
20. Quinones F., Crouch E. Biosynthesis of interstitial and basement membrane collagens in pulmonary fibrosis. Am. Rev. Respir. Dis. 134:1986;1163-1171.
21. Rippe R.A., Umezawa A., Kimball J.P., Breindl M., Brenner D.A. Binding of upstream stimulatory factor to an E-box in the 3′-flanking region stimulates α1(I) collagen gene transcription. J. Biol. Chem. 272:1997;1753-1760.
22. Rossert J., Eberspaecher H., de Crombrugghe B. Separate cis-acting DNA elements of the mouse pro-α1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J. Cell Biol. 129:1995;1421-1432.
23. Rossert J.A., Chen S.S., Eberspaecher H., Smith C.N., de Crombrugghe B. Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts. Proc. Natl. Acad. Sci. U.S.A. 93:1996;1027-1031.
24. Roux C., Dougados M., Abel L., Mercier G., Lucotte G. Association of a polymorphism in the collagen I α1 gene with osteoporosis in French women. Arthritis Rheum. 41:1998;187-188.
25. Schrier D.J., Kinkel R.G., Phan S.H. The role of strain variation in murine bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 127:1983;63-66.
26. Schrier D.J., Phan S.H. Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamide-sensitive T cells. Am. J. Pathol. 116:1984;270-278.
27. Sekhon H.S., Thurlbeck W.M. Lung growth in hypobaric normoxia, normobaric hypoxia, and hypobaric hypoxia in growing rats: I. Biochemistry. J. Appl. Physiol. 78:1995;124-131.
28. Slack J.L., Liska D.J., Bornstein P. An upstream regulatory region mediates high level, tissue-specific expression of the human α1(I) collagen gene in transgenic mice. Mol. Cell Biol. 11:1991;2066-2074.
29. Sokolov B.P., Ala-Kokko L., Dhulipala R., Arita M., Khillan J.S., Prockop D.J. Tissue-specific expression of the gene for type I procollagen (COL1A1) in transgenic mice: Only 476 base pairs of the promoter are required if collagen genes are used as reporters. J. Biol. Chem. 270:1995;9622-9629.
30. Sokolov B.P., Mays P.K., Khillan J.S., Prockop D.J. Tissue- and development-specific expression in transgenic mice of a type I procollagen (COL1A1) minigene construct with 2.3 kb of the promoter region and 2 kb of the 3′-flanking region. Specificity is independent of the putative regulatory sequences in the first intron. Biochemistry. 32:1993;9242-9249.
31. Swiderski R.E., Dencoff J.E., Floerchinger C.S., Shapiro S.D., Hunninghake G.W. Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 152:1998;821-828.
32. Uitterlinden A.G., Burger H., Huang W.J.et al. Relation of alleles of the collagen type I alpha 1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N. Engl. J. Med. 338:1998;1016-1021.
33. Willing M., Sowers M., Aron D.et al. Bone mineral density and its change in white women: Estrogen and vitamin D receptor genotypes and their interaction. J. Bone Miner. Res. 13:1998;695-705.
34. Woessner J.F. Jr. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93:1961;440-447.
35. Zhao Y., Young S.L., Mcintosh J.C. Induction of tenascin in rat lungs undergoing bleomycin-induced pulmonary fibrosis. Am. J. Phys. Lung Cell. Mol. Physiol. 18:1998;L1049-L1057.