Multipoint linkage analysis. A cautionary note

Human Heredity

Volumn 49, Issue 4, 1999, Pages 194-196

  Halpern, Jerry ^a   Whittemore, Alice S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genetic distance; Polymorphic information content; Statistical power

Indexed keywords

ARTICLE; COMPUTER SIMULATION; GENE LOCUS; GENETIC DISORDER; GENETIC LINKAGE; GENETIC MARKER; HUMAN; STATISTICS;

EID: 0032807294     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022874     Document Type: Article

References (14)

1. Lathrop GM, Lalouel JM, Julier C, Ott J: Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 1984;81:3443-3446.
2. Lathrop GM, Lalouel JM Julier C, Ott: Multilocus linkage analysis in humans: Detection of linkage and estimation of recombination. Am J Hum Genet 1985;37:482-498.
3. Lander ES, Green P: Construction of multilocus genetic maps in humans. Proc Natl Acad Sci USA 1987;84:2363-2367.
4. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES: Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 1996;58:1347-1363.
5. O'Connell JR, Weeks DE: The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzi inheritance. Nat Genet 1995;11:402-408.
6. Ott J: Analysis of Human Genetic Linkage. Baltimore, Johns Hopkins University Press, 1991.
7. Hsieh C-L, Oakley-Girvan I, Gallagher RP, Wu AH, Kolonel LN, Teh C-Z, Halpern J, West DW, Paffenbarger RS Jr, Whittemore AS: Prostate cancer susceptibility locus on chromosome 1q: A confirmatory study (letter). JNCI 1997;89:1893-1894.
8. Whittemore AS, Halpern J: A class of tests for linkage using affected pedigree members. Biometrics 1994;50:118-127.
9. Smith JR, Freije D, Carpten JD, Grönberg H, Xu J, Isaacs SD, Brownstein MJ, Bova GS, Guo H, Bujnovszky P, Nusskern DR, Damber J-E, Bergh A, Emanuelsson M, Kallioniemi OP, Walker-Daniels J, Bailey-Wilson JE, Beaty TH, Meyers DA, Walsh PC, Collins FS, Trent JM, Isaacs WB: Major susceptibility locus for prostate cancer on chromosome 1 suggested by genome-wide search. Science 1996;274:1371-1374.
10. Whittemore AS, Tu I-P: Simple, robust linkage tests for affected sibs. Am J Hum Genet 1998; 62:1228-1242.
11. Risch N: Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990;46:222-228.
12. Buetow KH: Influence of aberrant observations on high-resolution linkage analysis outcomes. Am J Hum Genet 1991;49:985-994.
13. Risch N, Giuffra L: Model misspecification and multipoint linkage analysis. Hum Hered 1992;42:77-92.
14. Daw EW, Thompson EA, Wijsman EM: Bias in multipoint linkage analysis arising from map misspecification (abstract). Annual Meeting of the American Society of Human Genetics, Denver, 1998.