Methotrexate improves biochemical tests in patients with primary biliary cirrhosis who respond incompletely to ursodiol

Gastroenterology

Volumn 117, Issue 2, 1999, Pages 395-399

  Bonis, P A L ^a   Kaplan, M ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; COLCHICINE; METRONIDAZOLE; URSODEOXYCHOLIC ACID;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; APHTHOUS ULCER; ARTICLE; CLINICAL ARTICLE; DIARRHEA; DRUG EFFICACY; DRUG MIXTURE; FEMALE; HUMAN; HUMAN TISSUE; LEUKOPENIA; LIVER BIOPSY; LIVER FUNCTION TEST; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; THROMBOCYTOPENIA;

EID: 0032805850     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.1999.0029900395     Document Type: Article

References (24)

1. MM. Kaplan Primary biliary cirrhosis N Engl J Med 335 1996 1570 1580
2. RE Poupon R Poupon B. Balkau Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group N Engl J Med 330 1994 1342 1347
3. KD Lindor TM Therneau RA Jorgensen M Malinchoc ER. Dickson Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis Gastroenterology 110 1996 1515 1518
4. KD Lindor ER Dickson RA Jorgensen ML Anderson RH Wiesner GJ Gores SM Lange SS Rossi AF Hofmann WP. Baldus The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study Hepatology 22 1995 1158 1162
5. B Combes RL Carithers Jr. WC Maddrey D Lin MF McDonald DE Wheeler EH Eigenbrodt SJ Munoz R Rubin G. Garcia-Tsao A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis Hepatology 22 1995 759 766
6. R Poupon K Lindor K Cauch-Dudek E Dickson R Poupon E. Heathcote Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis Gastroenterology 113 1997 884 890
7. M Vuoristo M Farkkila AL Karvonen R Leino J Lehtola J Makinen J Mattila C Friman K Seppala J Tuominen TA. Miettinen A placebo-controlled trial of primary biliary cirrhosis treatment with colchicine and ursodeoxycholic acid Gastroenterology 108 1995 1470 1478
8. MM Kaplan TA. Knox Treatment of primary biliary cirrhosis with low-dose weekly methotrexate Gastroenterology 101 1991 1332 1338
9. MM Kaplan RA DeLellis HJ. Wolfe Sustained biochemical and histologic remission of primary biliary cirrhosis in response to medical treatment Ann Intern Med 126 1997 682 688
10. RE Poupon PM Huet R Poupon AM Bonnand JT Nhieu ES. Zafrani A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis. UDCA-PBC Study Group Hepatology 24 1996 1098 1103
11. EJ Heathcote K Cauch-Dudek V Walker RJ Bailey LM Blendis CN Ghent P Michieletti GY Minuk SC Pappas LJ. Scully The Canadian Multicenter Double-blind Randomized Controlled Trial of ursodeoxycholic acid in primary biliary cirrhosis Hepatology 19 1994 1149 1156
12. J Shibata S Fujiyama Y Honda T. Sato Combination therapy with ursodeoxycholic acid and colchicine for primary biliary cirrhosis J Gastroenterol Hepatol 7 1992 277 282
13. KD Lindor ER Dickson WP Baldus RA Jorgensen J Ludwig PA Murtaugh JM Harrison RH Wiesner ML Anderson SM. Lange Ursodeoxycholic acid in the treatment of primary biliary cirrhosis Gastroenterology 106 1994 1284 1290
14. HP Buscher Y Zietzschmann W. Gerok Positive responses to methotrexate and ursodeoxycholic acid in patients with primary biliary cirrhosis responding insufficiently to ursodeoxycholic acid alone J Hepatol 18 1993 9 14
15. P. Scheuer Primary biliary cirrhosis Proc R Soc Med 60 1967 1257 1260
16. A Sharma D Provenzale A McKusick MM. Kaplan Interstitial pneumonitis after low-dose methotrexate therapy in primary biliary cirrhosis Gastroenterology 107 1994 266 270
17. R Poupon Y Chretien RE Poupon F Ballet Y Calmus F. Darnis Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis? Lancet 1 1987 834 836
18. S Munoz RL Carithers SS Emmerson N Fine K Kowdley B. Combs Absence of pulmonary toxicity in primary biliary cirrhosis (PBC) treated with methotrexate and ursodiol Hepatology 28 1998 392A (abstr)
19. H Zachariae H. Sogaard Methotrexate-induced liver cirrhosis: a follow-up Dermatologica 175 1987 178 182
20. MM. Kaplan Methotrexate hepatotoxicity and the premature reporting of Mark Twain's death: both greatly exaggerated Hepatology 12 1990 784 786
21. MM Kaplan DW Alling HJ Zimmerman HJ Wolfe RA Sepersky GS Hirsch GH Elta KA Glick KA. Eagen A prospective trial of colchicine for primary biliary cirrhosis N Engl J Med 315 1986 1448 1454
22. TW Warnes A Smith FI Lee NY Haboubi PJ Johnson L. Hunt A controlled trial of colchicine in primary biliary cirrhosis. Trial design and preliminary report J Hepatol 5 1987 1 7
23. W Van Steenbergen R Sciot P Van Eyken V Desmet J. Fevery Combined treatment with methotrexate and ursodeoxycholic acid in non-cirrhotic primary biliary cirrhosis Acta Clin Belg 51 1996 8 18
24. S Karne PAL. Bonis A systematic review of methotrexate in the treatment of primary biliary cirrhosis Hepatology 28 1998 649A (abstr)