Long-term clinical outcome after β-interferon therapy in cirrhotic patients with chronic hepatitis C

Hepato-Gastroenterology

Volumn 46, Issue 30, 1999, Pages 3216-3222

  Bernardinello, Elisabetta ^b   Cavalletto, Luisa ^b   Chemello, Liliana ^a   Mezzocolli, Ilenia ^b   Donada, Carlo ^b   Benvegnú, Luisa ^b   Merkel, Carlo ^b   Gatta, Angelo ^b   Alberti, Alfredo ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b NONE

Author keywords

IFN; Chronic hepatitis C; Cirrhosis; Long term outcome

Indexed keywords

ALANINE AMINOTRANSFERASE; BETA INTERFERON;

ADULT; ARTICLE; ASCITES; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FOLLOW UP; HEPATIC ENCEPHALOPATHY; HEPATITIS C; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; FEMALE; FOLLOW-UP STUDIES; HEPACIVIRUS; HEPATITIS C ANTIBODIES; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-BETA; LIVER CIRRHOSIS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RNA, VIRAL; TREATMENT OUTCOME;

EID: 0032805728     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. 1 Omata M, Yokosuka O, Takano S, et al: Resolution of acute hepatitis C after therapy with natural beta Interferon. Lancet 1991; 338:914-915.
2. 2 Takano S, Satomura Y, Omata M, Japan Acute Hepatitis Cooperative Study Group: Effects of interferon Beta on Non-A, Non-B acute hepatitis: a prospective, randomized, controlled-dose study. Gastroenterol 1994; 107:805-811.
3. 3 NIH Consensus Development Conference: "Management of Hepatitis C". Hepatol 1997; 26:1S-152S.
4. 4 Chemello L, Cavalletto L, Noventa F, et al: Predictors of sustained response, relapse and no response in patients with chronic hepatitis C treated with interferon alpha. J Viral Hepatitis 1995; 2:91-96.
5. 5 Davis GL, Lau JYN: Factors predictive of a beneficial response to therapy of hepatitis C. Hepatol 1997; 26:122S-127S.
6. 6 Idilman R, De Maria N, Colantoni A, Dokmeci A, Van Thiel DH: Interferon treatment of cirrhotic patients with chronic hepatitis C. J Viral Hepatitis 1997; 4:81-91.
7. 7 Schalm SW, Fattovich G, Brouwer JT: Therapy of hepatitis C: patients with cirrhosis. Hepatol 1997; 26:128S-132S.
8. 8 Nishiguchi S, Kuroki T, Nakatani S: Randomized trial of effects of interferon-α on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet 1995; 46:1051-1055.
9. 9 International Interferon-α Hepatocellular Carcinoma Study Group: Effect of interferon-α on progression of cirrhosis to hepatocellular carcinoma: a retrospective cohort study. Lancet 1998; 351:1535-1539.
10. 10 Fattovich G, Giustina G, Degos F, et al: Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterol 1997; 112:481-491.
11. 11 Kobayashi Y, Watanabe S, Konishi M, et al: Quantitation and typing of serum hepatitis C virus RNA in patients with chronic hepatitis C treated with interferon-β. Hepatol 1993; 18:1319-1325.
12. 12 Chemello L, Silvestri E, Cavalletto L, et al: Pilot study on the efficacy of intravenous natural β-interferon therapy in Italian patients with chronic hepatitis C and relation to the HCV genotype. International Hepatol Commun 1995; 3:237-243.
13. 13 Pérez R, Pravia R, Artimez L, et al: Clinical efficacy of intramuscular human interferon-β vs. interferon-α2b for the treatment of chronic hepatitis C. J Viral Hepatitis 1995; 2:103-106.
14. 14 Villa E, Trande P, Grottola A, et al: Alpha but not beta interferon is useful in chronic active hepatitis due to hepatitis C virus. A prospective, double-blind, randomized study. Dig Dis Sciences 1996; 41:1241-1247.
15. 15 Beppu K, Inokuchi K, Koyanagy N, et al: Prediction of variceal haemorrhage by oesophageal endoscopy. Gastrointest Endosc 1981; 27:213-218.
16. 16 Kaplan EL, Meier P: Non parametric estimation from incomplete observations. J Am Stat Assoc 1958; 53:458-481.
17. 17 Mantel N, Haenzel W: Statistical aspects of the analysis of data from retrospective studies of diseases. J Natl Cancer Inst 1959; 22:719-748.
18. 18 Kakumu S, Yoshioka K, Wakita T, et al: A pilot study of ribavirin and interferon beta for the treatment of chronic hepatitis C. Gastroenterol 1993; 105:507-512.