Increased serum soluble IL-2 receptor levels following interferon therapy in patients with chronic hepatitis C

Hepato-Gastroenterology

Volumn 46, Issue 27, 1999, Pages 1827-1830

  Sugimura, Takashi ^b   Motomura, Seiji ^c   Sakai, Hironori ^a   Nawata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c NONE

Author keywords

interferon; Cellular immunity; Cytokine; Hepatitis C virus; T lymphocyte

Indexed keywords

ALPHA INTERFERON; INTERLEUKIN 2 RECEPTOR; VIRUS RNA;

ADULT; AGED; ARTICLE; CELLULAR IMMUNITY; CHRONIC HEPATITIS; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE;

ADULT; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; IMMUNITY, CELLULAR; INJECTIONS, INTRAMUSCULAR; INTERFERON-ALPHA; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MONITORING, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-2; RNA, VIRAL; TREATMENT OUTCOME;

EID: 0032804761     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Kanai K, Kako M, Okamoto H: HCV genotypes in chronic hepatitis C and response to interferon. Lancet 1992; 339:1543.
2. Yoshioka K, Kakumu S, Wakita T, et al: Detection of hepatitis C virus by polymerase chain reaction and response to interferon-α therapy: relationship to genotypes of hepatitis C virus. Hepatol 1992; 16:293-299.
3. Tsubota A, Chayama K, Ikeda K, et al: Factors predictive of response to interferon-a therapy in hepatitis C virus infection. Hepatol 1994; 19:1088-1094.
4. Hino K, Sainokami S, Shimoda K, et al: Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C. J Med Virol 1994; 42:299-305.
5. Tsubota A, Chayama K, Arase Y, et al: Factors useful in predicting the response to interferon therapy in chronic hepatitis C. J. Gastroenterol. Hepatology 1993; 8:535-539.
6. Tilg H: The role of cytokines in the pathophysiology of chronic liver diseases. Int J Clin Lab Res 1993; 23:179-185.
7. Rubin LA, Jay G, Nelson DL: The released interleukin 2 receptor binds interleukin 2 efficiently. J Immunol 1986; 137:3841-3844.
8. Robb RJ, Kutny RM: Structure-function relationships for the IL-2 receptor system. IV. Analysis of the sequence and ligand-binding properties of soluble Tac protein. J Immnol 1987; 139:855-862.
9. Müller C, Knoflach P, Zielinski CC: Soluble interleukin 2 receptor in acute viral hepatitis and chronic liver disease. Hepatol 1989; 10:928-932.
10. Makris M, Preston FE, Ralph S: Increased soluble IL-2 receptor levels in HCV-infected haemophiliacs: a possible indicator of liver disease severity. Br J Haematol 1994; 87:419-421.
11. Rubin LA, Kurman CC, Fritz ME, et al: Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol 1985; 135:3172-3177.
12. Symons JA, Wood NC, Di Giovine FS, Duff GW: Soluble IL-2 receptor in rheumatoid arthritis correlation with disease activity, IL-1 and IL-2 inhibition. J. Immunol. 1988; 141:2612-2618.
13. Balderas RS, Josimovic-Alasevic O, Diamantstein T, et al: Elevated titers of cell-free interleukin 2 receptor in serum of lupus mice. J Immunol 1987; 139:1496-1500.
14. Wagner DK, Kiwanuka J, Edwards BK, et al: Soluble interleukin-2 receptor levels in patients with undifferentiated and lymphoblastic lymphomas: correlation with survival. J Clin Oncol 1987; 5:1262-1274.
15. Adams DH, Wang L, Hubscher SG, et al: Soluble interleukin-2 receptors in serum and bile of liver transplant recipients. Lancet 1989; 1:469-471.