Stress and the cell nucleus: Dynamics of gene expression and structural reorganization

Gene Expression

Volumn 7, Issue 4-6, 1999, Pages 261-270

  Jolly, Caroline ^a   Morimoto, Richard I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Heat shock; HSFs; HSPs; Nuclear function; Nuclear structure

Indexed keywords

HEAT SHOCK PROTEIN; RNA;

CELL COMPARTMENTALIZATION; CELL CYCLE; CELL GROWTH; CELL NUCLEUS; CELL NUCLEUS MATRIX; CELL ULTRASTRUCTURE; CHROMOSOME; CONFERENCE PAPER; CYTOARCHITECTURE; GENE EXPRESSION; HEAT SHOCK; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOLUS; RNA METABOLISM; STRESS;

ANIMALS; CELL COMPARTMENTATION; CELL NUCLEUS; GENE EXPRESSION; HUMANS; MODELS, BIOLOGICAL;

EID: 0032804190     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (89)

1. Barry, M. A.; Behnke, C. A.; Eastman, A. Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem. Pharmacol. 40:2353-2362; 1990.
2. Berezney, R.; Coffey, D. S. Identification of a nuclear protein matrix. Biochem. Biophys. Res. Commun. 60:1410-1417; 1974.
3. Bond, U. Heat shock but not other stress inducers leads to the disruption of a sub-set of snRNPs and inhibition of in vitro splicing in HeLa cells. EMBO J. 7:3509-3518; 1988.
4. Bridger, J. M.; Herrmann, H.; Munkel, C.; Lichter, P. Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin. J. Cell Sci. 111:1241-1253; 1998.
5. Brostom, C. O.; Brostom, M. A. Regulation of translational initiation during cellular responses to stress. Prog. Nucleic Acid Res. Mol. Biol. 58:79-125; 1998.
6. Chalfie, M.; Tu, Y.; Euskirchen, G.; Ward, W. W.; Prascher, D. C. Green fluorescent protein as a marker for gene expression. Science 263:802-805; 1994.
7. Corell, R. A.; Gross, R. H. Splicing thermotolerance maintains pre-mRNA transcripts in the splicing pathway during severe heat shock. Exp. Cell Res. 202:233-242; 1992.
8. Cotto, J. J.; Fox, S. G.; Morimoto, R. I. HSF1 granules: A novel stress-induced nuclear compartment of human cells. J. Cell Sci. 110:2925-2934; 1997.
9. Cremer, T.; Kurz, A.; Zirbel, R.; Dietzel, S.; Rinke, B.; Schröck, E.; Speicher, M. R.; Mathieu, U.; Jauch, A.; Emmerich, P.; Scherthan, H.; Ried, T.; Cremer, C.; Lichter, P. Role of chromosome territories in the functional compartmentalization of the cell nucleus. Cold Spring Harbor Symp. Quant. Biol. 58:777-792; 1993.
10. Du, L.; Warren, S. L. A functional interaction between the carboxy-terminal domain of RNA polymerase II and pre-mRNA splicing. J. Cell Biol. 136:5-18; 1997.
11. Edwards, M. J. Apoptosis, the heat shock response, hyperthermia, birth defects, disease and cancer. Where are the common links? Cell Stress Chaperones 3:213-220; 1998.
12. Eils, R.; Dietzel, S.; Bertin, E.; Schröck, E.; Speicher, M. R.; Ried, T.; Robert-Nicoud, M.; Cremer, C.; Cremer, T. Three-dimensional reconstruction of painted human interphase chromosomes: Active and inactive X chromosome territories have similar volumes but differ in shape and surface structure. J. Cell Biol. 135:1427-1440; 1996.
13. Elgin, S. C. Heterochromatin and gene regulation in Drosophila. Curr. Opin. Genet. Dev. 6:193-202; 1996.
14. Fu, X.-D.; Maniatis, T. Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature 343:437-441; 1990.
15. Gabai, V. L.; Meriin, A. B.; Yaglom, J. A.; Volloch, V. Z.; Sherman, M. Y. Role of Hsp70 in regulation of stress-kinase JNK: Implications in apoptosis and aging. FEBS Lett. 438:1-4; 1998.
16. Gattoni, R.; Mahe, D.; Mahl, P.; Fischer, N.; Mattei, M. G.; Stevenin, J.; Fuchs, J. P. The human hnRNP-M proteins: Structure and relation with early heat shock-induced splicing arrest and chromosome mapping. Nucleic Acids Res. 24:2535-2542; 1996.
17. Georgopoulos, C.; Welch, W. J. Role of the major heat shock proteins as molecular chaperones. Annu. Rev. Cell Biol. 9:601-634; 1993.
18. Ghoshal, K.; Jacob, S. T. Heat shock selectively inhibits ribosomal RNA gene transcription and down-regulates E1BF/Ku in mouse lymphosarcoma cells. Biochem. J. 317:689-695; 1996.
19. Gottschling, D. E.; Aparicio, O. M.; Billington, B. L.; Zakian, V. A. Position effect of S. cerevisiae telomeres: Reversible repression of Pol II transcription. Cell 63:751-762; 1990.
20. Jolly, C.; Morimoto, R. I.; Robert-Nicoud, M.; Vourc'h, C. Nuclear foci enriched in HSF1 transcription factor: Relationship with heat shock gene transcription sites. J. Cell Sci. 110:2935-9241; 1997.
21. Jolly, C.; Robert-Nicoud, M.; Vourc'h, C. Contribution of the growing RNA molecules to the nuclear transcripts foci observed by FISH. Exp. Cell Res. 238:299-304; 1998.
22. Kurz, A.; Lampel, S.; Nickolenko, J. E.; Bradl, J.; Benner, A.; Zirbel, R. M.; Cremer, T.; Lichter, P. Active and inactive genes localize preferentially in the periphery of chromosome territories. J. Cell Biol. 135:1195-1205; 1996.
23. Lamond, A. I.; Earnshaw, W. C. Structure and function in the nucleus. Science 280:547-553; 1998.
24. Lerner, E. A.; Lerner, M. R.; Janeway, C. A. J.; Steitz, J. A. Monoclonal antibodies to nucleic acid-containing cellular constituents: Probes for molecular biology and autoimmune disease. Proc. Natl. Acad. Sci. USA 78:2737-2741; 1981.
25. Lindquist, S. The heat-shock response. Annu. Rev. Biochem. 55:1151-11191; 1986.
26. Liu, Y.; Liang, S.; Tartakoff, A. M. Heat shock disassembles the nucleolus and inhibits nuclear protein import and poly(A)+ export. EMBO J. 15:6750-6757; 1996.
27. Martinez-Balbás, M. A.; Dey, A.; Rabindran, S.; Ozato, K.; Wu, C. Displacement of sequence-specific transcription factors from mitotic chromatin. Cell 83:29-38; 1995.
28. Matera, A. G. Of coiled bodies, gems, and salmon. J. Cell. Biochem. 70:181-192; 1998.
29. Mathew, A.; Mathur, S. K.; Morimoto, R. I. Heat shock response and protein degradation: Regulation of HSF2 by the ubiquitin-proteasome pathway. Mol. Cell. Biol. 18:5091-5098: 1998.
30. McCracken, S.; Fong, N.; Yankulov, K.; Ballantyne, S.; Pan, G.; Greenblatt, J.; Patterson, S. D.; Wickens, M.; Bentley, D. L. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature 385:357-361; 1997.
31. Minchiotti, G.; Gargano, S.; Maresca, B. The intron-containing hsp82 gene of the dimorphic pathogenic fungus Histoplasma capsulation is properly spliced in severe heat shock conditions. Mol. Cell. Biol. 11:5624-5630; 1991.
32. Miriami, E.; Sperling, J.; Sperling, R. Heat shock affects 5'′ splice site selection, cleavage and ligation of CAD pre-mRNA in hamster cells, but not its packaging in lnRNP particles. Nucleic Acids Res. 22:3084-3091; 1994.
33. Misteli, T.; Spector, D. L. Applications of the green fluorescent protein in cell biology and biotechnology. Nature Biotechnol. 15:961-964; 1997.
34. Misteli, T.; Cáceres, J. F.; Spector, D. L. The dynamics of a pre-mRNA splicing factor in living cells. Nature 387:523-527; 1997.
35. Misteli, T.; Spector, D. L. The cellular organization of gene expression. Curr. Opin. Cell Biol. 10:322-331; 1998.
36. Moen, P. T., Jr.; Smith, K. P.; Lawrence, J. B. Compartmentalization of specific pre-mRNA metabolism: An emerging view. Hum. Mol. Genet. 4:1779-1789; 1995.
37. Moerman, A. M.; de Maria, A. C.; Gomes, S. L.; Klein, C. Heat shock alters poly(A) tail length of Dictyostelium discoideum hsp32 RNA. DNA Cell Biol. 17:635-641; 1998.
38. Moore, M.; Schaack, J.; Baim, S. B.; Morimoto, R. I.; Shenk, T. Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells. Mol. Cell. Biol. 7:4505-4512; 1987.
39. Morimoto, R. I. Cells in stress: Transcriptional activation of heat shock genes. Science 259:1409-1410; 1993.
40. Morimoto, R. I.; Kroeger, P. E.; Cotto, J. J. The transcriptional regulation of heat shock genes: A plethora of heat shock factors and regulatory conditions. In: Morimoto, R. I.; Feige, U.; Yahara, I.; Polla, B. S., eds. Stress inducible cellular responses. Basel: Birkhaüser Verlag; 1996:139-163.
41. Morimoto, R. I. Regulation of the heat shock transcriptional response: Cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes Dev. 12:3788-3796; 1998.
42. Mortillaro, M. J.; Blencowe, B. J.; Wei, X.; Nakayasu, H.; Du, L.; Warren, S. L.; Sharp, P. A.; Berezney, R. A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. Proc. Natl. Acad. Sci. USA 93:8253-8257; 1996.
43. Mosser, D. D.; Caron, A. W.; Bourget, L.; Denis-Larose, C.; Massie, B. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol. Cell. Biol. 17:5317-5327; 1997.
44. Muhich, M. L.; Boothroyd, J. C. Synthesis of trypanosome hsp70 mRNA is resistant to disruption of transsplicing by heat shock. J. Biol. Chem. 264:7107-7110; 1989.
45. Nakai, A.; Tanabe, M.; Kawazoe, Y.; Inazawa, J.; Morimoto, R. I.; Nagata, K. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol. Cell. Biol. 17:469-481; 1997.
46. Nitta, M.; Okamura, H.; Aizawa, S.; Yamaizumi, M. Heat shock induces transient p53-dependent cell cycle arrest at G1/S. Oncogene 15:561-568; 1997.
47. O'Brien, T.; Lis, J. T. RNA polymerase II pauses at the 5′ end of the transcriptionally induced Drosophila hsp70 gene. Mol. Cell. Biol. 11:5285-5290; 1991.
48. Osteryoung, K. W.; Sundberg, H.; Vierung, E. Poly(A) tail length of a heat shock protein RNA is increased by severe heat stress, but intron splicing is unaffected. Mol. Gen. Genet. 239:323-333; 1993.
49. Pederson, T. Thinking about a nuclear matrix. J. Mol. Biol. 277:147-159; 1998.
50. Pelham, H. R. B. A regulatory upstream promoter element in the Drosophila hsp70 heat-shock gene. Cell 30:517-528; 1982.
51. Rabindran, S. R.; Giorgi, G.; Clos, J.; Wu, C. Molecular cloning and expression of a human heat shock factor, HSF1. Proc. Natl. Acad. Sci. USA 88:6906-6910; 1991.
52. Ramon y Cajal, S. Un sencillo metodo de coloracion selectiva del reticulo protoplasmico y sus efectos en los diversos organos nerviosos. Trad. Lab. Invest. Biol. 2:129-221; 1903.
53. Rasmussen, E. B.; Lis, J. T. In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes. Proc. Natl. Acad. Sci. USA 90:7923-7927; 1993.
54. Rattan, S. I. Repeated mild heat shock delays ageing in cultured human skin fibroblasts. Biochem. Mol. Biol. Int. 45:753-759; 1998.
55. Richardson, A.; Holbrook, N. J. Aging and the cellular response to stress: Reduction in the heat shock response. In: Holbrook, N. J.; Martin, G. R.; Lockshin, R. A., eds. Cellular aging and cell death. New York: Wiley-Liss; 1996:67-80.
56. Roth, M. B. Spheres, coiled bodies and nuclear bodies. Curr. Opin. Cell Biol. 7:325-328; 1995.
57. Roti Roti, J. L.; Wright, W. D.; vanderWaal, R. The nuclear matrix: A target for heat shock effects and a determinant for stress response. Crit. Rev. Eukaryot. Gene Expr. 7:343-360; 1997.
58. Roti Roti, J. L.; Kampinga, H. H.; Malyapa, R. S.; Wright, W. D.; vanderWaal, R. P.; Xu, M. Nuclear matrix as a target for hyperthermic killing of cancer cells. Cell Stress Chaperones 3:245-255; 1998.
59. Rougvie, A. E.; Lis, J. T. The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged. Cell 54:795-804; 1988.
60. Rutherford, S. L.; Lindquist, S. Hsp90 as a capacitor for morphological evolution. Nature 396:336-342; 1998.
61. Sarge, K. D.; Murphy, S. P.; Morimoto, R. I. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Mol. Cell. Biol. 13:1392-1407; 1993.
62. Sato, N.; Torigoe, T. The molecular chaperones in cell cycle control. Ann. NY Acad. Sci. 851:61-66; 1998.
63. Schaffer, C. D.; Wallrath, L. L.; Elgin, S. C. R. Regulating genes by packaging domains: Bits of heterochromatin in euchromatin. Trends Genet. 9:3537; 1993.
64. Schuetz, T. J.; Gallo, G. J.; Sheldon, L.; Tempst, P.; Kingston, R. E. Isolation of a cDNA for HSF2: Evidence for two heat shock factor genes in humans. Proc. Natl. Acad. Sci. USA 88:6911-6915; 1991.
65. Shama, S.; Lai, C. Y.; Antoniazzi, J. M.; Jiang, J. C.; Jazwinski, S. M. Heat stress-induced life span extension in yeast. Exp. Cell Res. 245:379-388; 1998.
66. Shen, J.; Beall, C. J.; Hirsh, J. Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock. Mol. Cell. Biol. 13:4549-4555; 1993.
67. Singer, R. H.; Green, M. R. Compartmentalization of eukaryotic gene expression: Causes and effects. Cell 91:291-294; 1997.
68. Sistonen, L.; Sarge, K. D.; Phillips, B.; Abravaya, K.; Morimoto, R. I. Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Mol. Cell. Biol. 12:4104-4111; 1992.
69. Spector, D. L.; Fu, X.-D.; Maniatis, T. Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J. 10:3467-3481; 1991.
70. Spector, D. L.; Goldman, R. D.; Leinwand, L. A. Cells: A laboratory manual. New York: Cold Spring Harbor Laboratory Press; 1998.
71. Takechi, H.; Hosokawa, N.; Hirayoshi, K.; Nagata, K. Alternative 5′ splice site selection induced by heat shock. Mol. Cell. Biol. 14:567-575; 1994.
72. Tani, T.; Derby, R. J.; Hiraoka, Y.; Spector, D. L. Nucleolar accumulation of poly(A)+ RNA in heat-shocked yeast cells: Implication of nucleolar involvement in mRNA transport. Mol. Biol. Cell 7:173-192; 1996.
73. Thibodeau, A.; Vincent, M. Monoclonal antibody CC-3 recognizes phosphoproteins in interphase and mitotic cells. Exp. Cell Res. 195:145-153; 1991.
74. Tsien, R. Y. The green fluorescent protein. Annu. Rev. Biochem. 67:509-544; 1998.
75. vanderWaal R.; Thampy, G.; Wright, W. D.; Roti Roti, J. L. Heat-induced modifications in the association of specific proteins with the nuclear matrix. Radiat. Res. 145:746-753; 1996.
76. Vazquez, J.; Pauli, D.; Tissières, A. Transcriptional regulation in Drosophila during heat shock: A nuclear run-on analysis. Chromosoma 102:233-248; 1993.
77. Vogel, J. L.; Parsell, D. A.; Lindquist, S. Heat-shock proteins Hsp104 and Hsp70 reactivate mRNA splicing after heat inactivation. Curr. Biol. 5:306-617; 1995.
78. Walsh, D.; Li, K.; Wass, J.; Dolnikov, A.; Zeng, F.; Zhe, L.; Edwards, M. Heat-shock gene expression and cell cycle changes during mammalian embryonic development. Dev. Genet. 14:127-136; 1993.
79. Warters, R. L.; Brizgys, L. M.; Sharma,.R.; Roti Roti, J. L. Heat shock (45 degrees C) results in an increase of nuclear matrix protein mass in HeLa cells. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 50:253-268: 1986.
80. Welch, W. J.; Feramisco, J. R. Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells. J. Biol. Chem. 259:4501-4513; 1984.
81. Welch, W. J.; Suhan, J. P. Morphological study of the mammalian stress response: Characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatments. J. Cell Biol. 101:1198-1211; 1985.
82. Welch, W. J.; Gambetti, P. Chaperoning brain diseases. Nature 392:23-24; 1998.
83. Westra, A.; Dewey, W. C. Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 19:467-477; 1971.
84. Wu, C. Heat shock transcription factors: Structure and regulation. Annu. Rev. Cell. Dev. Biol. 11:441-469; 1995.
85. Yost, H. J.; Lindquist, S. RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis. Cell 45:185-193; 1986.
86. Yost, H. J.; Lindquist, S. Heat shock proteins affect RNA processing during the heat shock response of Saccharomyces cerevisiae. Mol. Cell. Biol. 11:1062-1068; 1991.
87. Yuryev, A.; Patturajan, M.; Litingtung, Y.; Joshi, R. V.; Gentile, C.; Gebara, M.; Corden, J. L. The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. Proc. Natl. Acad. Sci. USA 93:6975-6980; 1996.
88. Zeng, C. Q.; Kim, E.; Warren, S. L.; Berget, S. M. Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity. EMBO J. 16:1401-1412; 1997.
89. Zirbel, R. M.; Mathieu, U. R.; Cremer, T.; Lichter, P. Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries. Chrom. Res. 1:93-106; 1993.