Filgrastim treatment of HIV-infected patients improves neutrophil function

AIDS, Supplement

Volumn 13, Issue 2, 1999, Pages

  Pitrak, David L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Apoptosis; Filgrastim; HIV infection; Neutrophil function; Oxidative capacity; Recombinant methionyl human granulocyte colony stimulating factor

Indexed keywords

RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

APOPTOSIS; BACTERICIDAL ACTIVITY; CONFERENCE PAPER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NEUTROPHIL; PRIORITY JOURNAL; RESPIRATORY BURST;

ACQUIRED IMMUNODEFICIENCY SYNDROME; APOPTOSIS; BACTERIAL INFECTIONS; FILGRASTIM; HIV-1; HUMANS; NEUTROPENIA; NEUTROPHILS; RESPIRATORY BURST;

EID: 0032804115     PISSN: 13502840     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (33)

1. Witt DJ, Craven DE, McCabe WR. Bacterial infections in adult patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex. Am J Med 1987, 82:900-906.
2. Nichols L, Balogh K, Silverman M. Bacterial infections in the acquired immune deficiency syndrome. Am J Clin Pathol 1989, 92:787-790.
3. Kielhofner M, Atmar RL, Hamill RJ, Musher DM. Life-threatening Pseudomonas aeruginosa infections with human immunodeficiency virus infection. Clin Infect Dis 1992, 14:403-411.
4. Barat LM, Gunn JE, Steger KA, Perkins CJ, Craven DE. Causes of fever in patients infected with human immunodeficiency virus who were admitted to Boston City Hospital. Clin Infect Dis 1996, 23:320-328.
5. Stein M, O'Sullivan P, Wachtel T, et al. Causes of death in persons with human immunodeficiency virus infection. Am J Med 1992, 93:387-390.
6. Zon LI, Groopman JE. Hematologic manifestations of the human immunodeficiency virus (HIV). Semin Hematol 1988, 25:208-218.
7. Harbol AW, Liesveld JL, Simpson-Haidanis PJ, Abboud CN. Mechanisms of cytopenia in human immunodeficiency virus infection. Blood Rev 1994, 8:241-251.
8. Moore KD, Keruly J, Chaisson RE. Neutropenia and bacterial infection in acquired immunodeficiency syndrome. Arch Intern Med 1995, 155:1965-1970.
9. Keiser P, Higgs E, Smith J. Neutropenia is associated with bacteremia in patients infected with the human immunodeficiency virus. Am J Med Sci 1996, 312:118-122.
10. Jacobson MA, Liu RC, Davies D, Cohen PT. Human immunodeficiency virus disease related neutropenia and the risk of hospitalisation for bacterial infection. Arch Intern Med 1997, 157:1823-1831.
11. Pitrak DL, Tsai HC, Mullane KM, Sutton SH, Stevens P. Accelerated neutrophil apoptosis in the aquired immunodeficiency syndrome. J Clin Invest 1996, 98:2714-2719.
12. Klebanoff SJ, Coombs RW. Viricidal effect of polymorphonuclear leukocytes on human immunodeficiency virus. J Clin Invest 1992, 89:2014-2017.
13. Baldwin GC, Gasson JC, Quan SG, et al. Granulocyle-macrophage colony-stimulating factor enhances neutrophil function in acquired immunodeficiency syndrome patients. Proc Natl Acad Sci 1988, 85:2763-2766.
14. Flo RW, Noess A, Nilsen A, Harthug S, Solberg CO. A longitudinal study of phagocyte function in HIV-infected patients. AIDS 1994, 8:771-777.
15. Ellis M, Gupta S, Gallant S, et al. Impaired neutrophil function in patients with AIDS or AIDS-related complex: a comprehensive evaluation. J Infect Dis 1988, 158:1268-1276.
16. Nielsen H, Kharazmi A, Faber V. Blood monocyte and neutrophil functions in the acquired immunodeficiency syndrome. Scand J Immunol 1986, 24:291-296.
17. Pitrak DL, Bak PM, DeMarais P, Novak RM, Andersen BR. Depressed neutrophil superoxide production in human immunodeficiency virus infection. J Infect Dis 1993, 167:1406-1410.
18. Gabrilovich D, Ivanova L, Serebrovskaya L, Shepeleva G, Pokrovsky V. Clinical significance of neutrophil function activity in HIV infection. Scand J Infect Dis 1994, 26:41-47.
19. Elbim C, Prevot MH, Bouscarat F, et al. Polymorphonuclear neutrophils from human immunodeficiency virus-infected patients show enhanced activation, diminished fMLP-induced L-selectin shedding, and an impaired oxidative burst after cytokine priming. Blood 1994, 84:2759-2766.
20. Laursen AL, Rungby J, Andersen PL. Decreased activation of the respiratory burst in neutrophils from AIDS patients with previous Pneumocystis carinii pneumonia. J Infect Dis 1995, 172:497-505.
21. Pitrak DL, Mullane KM, Bilek ML, Stevens P, Allen RC. Impaired phagocyte oxidative capacity in patients with human immunodeficiency virus infection. J Clin Lab Med 1998, 132:284-294.
22. Allen RC. Phagocytic leukocyte oxygenation activities and chemiluminescence: a kinetic approach to analysis. Methods Enzymol 1986, 133:449-493.
23. Allen RC, Stevens DL. The circulating phagocyte reflects the in vivo state of the immune system. Curr Opin Infect Dis 1992, 5:309-395.
24. Bandres JC, Trial J, Musher DM, Rossen RD. Increased phagocytosis and generation of reactive oxygen product by neutrophils and monocytes of men with stage 1 human immunodeficiency virus infection. J Infect Dis 1993, 168:75-83.
25. Murphy PM, Lane HC, Fauci AS, Gallin JI. Impairment of neutrophil bactericidal capacity in patients with AIDS. J Infect Dis 1988, 158:627-630.
26. Wyllie AH, Kerr JFR, Currie AK. Cell death: the significance of apoptosis. Int Rev Cytol 1980, 68:251-306.
27. Cohen JJ. Programmed cell death in the immune system. Adv Immunol 1991, 50:55-85.
28. Pitrak DL, Mullane K, Bilek M, Skariah A, Porter L, Wong R. Filgrastim (r-metHuG-CSF) treatment of HIV-infected patients improves neutrophil function [abstract Th.B.4181]. XI International Conference on AIDS. Vancouver, July 1996:282.
29. Pitrak DL, Sutton SH, Tsai HC, et al. Accelerated neutrophil apoptosis in AIDS: partial reversal with r-metHuG-CSF [abstract]. 33rd Annual Meeting of the Infectious Diseases Society of America, San Francisco, 1995:508.
30. Su E, Verral S, Pitrak DL. IL-2 and G-CSF inhibit apoptosis of peripheral blood mononuclear cells (PBMC) and neutrophils (PMNL) by increasing Bcl-2 expression [abstract]. J Invest Med 1997, 145:274A.
31. Mauss S, Steinmetz HT, Jablonski H, Häussinger D. Lack of induction of granulocyte colony-stimulating factor in human immunodeficiency virus-seropositive individuals. Blood 1996, 88:1897-1898.
32. Moses AM, Heneveld M, Nelson JA, Williams S, Rarick M, Bagby GC. CD34 bone marrow microvascular endothelial cells (MVEC) are consistently infected by HIV-1 in patients with AIDS. Suboptimal release of IL-6 and G-CSF by infected stromal cells does not depend upon release of soluble inhibitory factors [abstract 1136]. Blood 1995, 86(suppl 1):287A.
33. Pitrak DL, Verral SC, Stevens P. Endogenous granulocyte colony-stimulating factor production by peripheral blood mononuclear cells in persons with acquired immunodeficiency syndrome. Curr Ther Res 1998, 59:263-268.