Disruption of cholecystokinin (CCK)-B receptor gene did not modify bile or pancreatic secretion or pancreatic growth: A study in CCK-B receptor gene knockout mice

Pancreas

Volumn 19, Issue 2, 1999, Pages 114-118

  Miyasaka, Kyoko ^a   Shinozaki, Hirotsugu ^b   Suzuki, Shinji ^a   Sato, Yuko ^a   Kanai, Setsuko ^a   Masuda, Masao ^a   Jimi, Atsuo ^c   Nagata, Aki ^d   Matsui, Toshimitsu ^d   Noda, Tetsuo ^e   Kono, Akira ^f   Funakoshi, Akihiro ^g  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b Inatsuki Hospital   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e CANCER INSTITUTE   (Japan)

^f Engineering Division   (Japan)

^g NATIONAL KYUSHU CANCER CENTER   (Japan)

Author keywords

Bile secretion.; CCK; CCK B receptor; CCK B receptor gene knockout mice; Pancreatic exocrine function

Indexed keywords

AMYLASE; BILE ACID; CARBACHOL; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; METHACHOLINE; SECRETIN;

ACINAR CELL; AMYLASE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE SECRETION; GENE DISRUPTION; GENE EXPRESSION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; ORGANOGENESIS; PANCREAS JUICE; PANCREAS SECRETION; PRIORITY JOURNAL;

EID: 0032803705     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-199908000-00002     Document Type: Article

References (16)

1. Johnson LR. Pancreatic secretion. In: Johnson LR, ed. Gastrointestinal physiology. St. Louis: Mosby, 1985:83-93.
2. Wank SA, Harkins R, Jensen RT, Shapira H, De Weerth A, Slattery T. Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas. Proc Natl Acad Sci USA 1992;89:3125-9.
3. Wank SA, Pisegna JR, Weerth A. Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression. Proc Natl Acad Sci USA 1992;89:8691-5.
4. Wank SA. Cholecystokinin receptors. Am J Physiol 1995;269: G628-46.
5. Funakoshi A, Miyasaka K, Shinozaki H, et al. An animal model of congenital defect of gene expression of cholecystokinin (CCK)-A receptor. Biochem Biophys Res Commun 1995;210:787-96.
6. Takiguchi S, Takata Y, Funakoshi A, et al. Disrupted cholecystokinin type-A receptor (CCK-AR) gene in OLETF rats. Gene 1997; 197:169-75.
7. Miyasaka K, Masuda M, Ohta M, Funakoshi A. Role of cholecystokinin (CCK)-A-receptor in pancreatic growth in rats during suckling period: a study in a naturally occurring CCK-A-receptor gene "knockout" rat. Pancreas 1997;14:103-5.
8. Miyasaka K, Ohta M, Kanai S, Sato Y, Masuda M, Funakoshi A. Role of cholecystokinin (CCK) A receptor for pancreatic growth after weaning: a study in a new rat model without gene expression of CCK A receptor. Pancreas 1996;12:351-6.
9. De Weerth A, Pisegna JR, Huppi K, Wank SA. Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. Biochem Biophys Res Commun 1993;194:811-8.
10. Morisset J, Levenez F, Corring T, Benrezzak O, Pelletier G, Calvo E. Pig pancreatic acinar cells possess predominantly the CCK-B receptor subtype. Am J Physiol 1996;271:E397-402.
11. Nagata A, Ito M, Iwata N, et al. G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. Proc Natl Acad Sci USA 1996;93:11825-30.
12. Williams JA, Korc M, Dormer RL. Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini. Am J Physiol 1978;235:E517-24.
13. Iwamoto Y, Nakamura R, Akanuma Y. In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol Jpn 1984;19:53-58.
14. Kitani K, Kanai S. Tauroursodeoxycholate prevents taurocholate induced cholestasis. Life Sci 1981;30:515-23.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193: 265-75.
16. Saillan-Barreau C, Clerc P, Adato M, et al. Transgenic CCK-B/ gastrin receptor mediates murine exocrine pancreatic secretion. Gastroenterology 1998;115:988-96.