Prophylactic treatment with growth hormone and insulin-like growth factor I improve systemic bacterial clearance and survival in a murine model of burn-induced gut-derived sepsis

Burns

Volumn 25, Issue 5, 1999, Pages 425-430

  Fukushima, Ryoji ^a   Saito, Hideaki ^b   Inoue, Tomomi ^b   Fukatsu, Kazuhiko ^b   Inaba, Tsuyoshi ^b   Han, Ilsoo ^b   Furukawa, Satoshi ^b   Lin, Ming Tsan ^b   Muto, Tetsuichiro ^b  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bacterial translocation; Growth hormone (GH); Gut derived sepsis; Insulin like growth factor I (IGF I)

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BACTERIAL TRANSLOCATION; BLOOD; BLOOD AUTOTRANSFUSION; BURN INFECTION; CONTROLLED STUDY; CRYPT CELL; ESCHERICHIA COLI; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE VILLUS; LIVER; MESENTERY LYMPH NODE; MITOSIS RATE; MOUSE; NONHUMAN; SEPSIS; SMALL INTESTINE; SPLEEN; SURVIVAL;

ANIMALS; BACTERIAL TRANSLOCATION; BURNS; COLONY COUNT, MICROBIAL; ESCHERICHIA COLI INFECTIONS; FEMALE; HUMAN GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; INTESTINES; MICE; MICE, INBRED BALB C; SEPSIS; SURVIVAL RATE;

EID: 0032803144     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0305-4179(98)00188-0     Document Type: Article

References (28)

1. Berg R.D., Garlington A.W. Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect. Immun. 23:1979;403-411.
2. Alexander J.W., Boyce S.T., Babcock G.F.et al. The process of microbial translocation. Ann. Surg. 212:1990;496-512.
3. Carrico W., Meakins J.L., Marschall J.C., Fry D., Maier R.V. Multiple-organ-failure syndrome. Arch. Surg. 121:1986;196-208.
4. Cotterill A.M., Mendel P., Holly J.M.et al. The differential regulation of the circulating levels of the insulin-like growth factors and their binding proteins (IGFBP) 1, 2 and 3 after elective abdominal surgery. Clin. Endocrinol. (Oxf). 44:1996;91-101.
5. Abribat T., Brazeau P., Davignon I., Garrel D.R. Insulin-like growth factor-I blood levels in severely burned patients: effects of time postinjury, age of patient and severity of burn. Clin. Endocrinol. 39:1993;583-589.
6. Dahn M.S., Mitchell R.A., Smith S., Lange M.P., Whitcomb M.P., Kirkpatrick J.R. Altered immunologic function and nitrogen metabolism associated with depression of plasma growth hormone. J. Parenter. Enteral. Nutr. 8:1984;690-694.
7. Jeevanandam M., Ramias L., Shamos R.F., Schiller W.R. Decreased growth hormone levels in the catabolic phase of severe injury. Surgery. 111:1992;495-502.
8. Hammarqvist F., Stromberg C., von der Decken A., Vinnars E., Wernerman J. Biosynthetic human growth hormone preserves both muscle protein synthesis and the decrease in muscle-free glutamine, and improves whole-body nitrogen economy after operation. Ann. Surg. 216:1992;184-191.
9. Voerman H.J., van Schijndel R.J., Groeneveld A.B.et al. Effects of recombinant human growth hormone in patients with severe sepsis. Ann. Surg. 216:1992;648-655.
10. Cioffi W.G., Gore D.C., Rue L.W.et al. Insulin-like growth factor-I lowers protein oxidation in patients with thermal injury. Ann. Surg. 220:1994;310-319.
11. Huang K.F., Chung D.H., Herndon D.N. Insulin-like growth factor-I (IGF-I) reduces gut atrophy and bacterial translocation after severe burn injury. Arch. Surg. 128:1993;47-53.
12. Kelley K.W. The role of growth hormone in modulation of the immune response. Ann. NY Acad. Sci. 594:1990;95-103.
13. Saito H., Inoue T., Fukatsu K.et al. Growth hormone and the immune response to bacterial infection. Horm. Res. 45:1996;50-54.
14. Edwards C.K., Yunger L.M., Lorence R.M., Dantzer R., Kelley K.W. The pituitary gland is required for protection against lethal effects of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA. 88:1991;22747.
15. Gomez-de-Segura I.A., Prieto I., Grande A.G.et al. Growth hormone reduces mortality and bacterial translocation in irradiated rats. Acta Oncol. 37:1998;179-185.
16. Inoue T., Saito H., Fukushima R.et al. Growth hormone and insulinlike growth factor I enhance host defense in a murine sepsis model. Arch. Surg. 130:1995;1115-1122.
17. Gianotti L., Pyles T., Alexander J.W., Babcock G.F., Carey M.A. Impact of blood transfusion and burn injury on microbial translocation and bacterial survival. Transfusion. 32:1992;312-317.
18. Fukushima R., Gianotti L., Alexander J.W., Pyles T. The degree of bacterial translocation is a determinant factor for mortality after burn injury and is improved by prostaglandin analogs. Ann. Surg. 216:1992;438-444. discussion 444-5.
19. Stieritz D.D., Holder I.A. Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: description of a burned mouse model. J. Infect. Dis. 131:1975;688-691.
20. Alexander J.W., Gianotti L., Pyles T., Carey M.A., Babcock G.F. Distribution and survival of Escherichia coli translocating from the intestine after thermal injury. Ann. Surg. 213:1991;558-566. discussion 566-7.
21. Vara-Thorbeck R., Guerrero J.A., Rosell J., Ruiz R.E., Capitan J.M. Exogenous growth hormone: effects on the catabolic response to surgically produced acute stress and on postoperative immune function. World J. Surg. 17:1993;530-538.
22. Inoue T., Saito H., Hashiguchi Y.et al. Growth hormone and insulin-like growth factor I augment Escherichia coli-killing activity of murine peritoneal exudative cells. Shock. 6:1996;345-350.
23. Fu Y.K., Arkins S., Li Y.M., Dantzer R., Kelley K.W. Reduction in superoxide anion secretion and bactericidal activity of neutrophils from aged rats: reversal by the combination of gamma interferon and growth hormone. Infect. Immun. 62:1994;1-8.
24. Zhang W., Frankel W.L., Adamson W.T.et al. Insulin-like growth factor-I improves mucosal structure and function in transplanted rat small intestine. Transplantation. 59:1995;755-761.
25. Chen K., Okuma T., Okamura K., Tabira Y., Kaneko H., Miyauchi Y. Insulin-like growth factor-I prevents gut atrophy and maintains intestinal integrity in septic rats. J. Parenter. Enteral. Nutr. 19:1995;119-124.
26. Lund P.K., Ulshen M.H., Rountree D.B., Selub S.E., Buchan A.M. Molecular biology of gastrointestinal peptides and growth factors: relevance to intestinal adaptation. Digestion. 2:1990;66-73.
27. Wells C., Erlandsen S. Localization of translocating Escherichia coli, Proteus mirabilis and Enterococcus faecalis within cecal and colonic tissues of monoassociated mice. Infect. Immun. 59:1991;4693-4697.
28. McCauley R.D., Heel K.A., Christiansen K.J., Hall J.C. The effect of minimum luminal nutrition on bacterial translocation and atrophy of the jejunum during parenteral nutrition. J. Gastroenterol. Hepatol. 11:1996;65-70.