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Volumn 13, Issue 6, 1999, Pages 897-903

In vitro assessment of paracetamol-induced toxicity in the rat Reuber hepatoma H4IIEC3/G- cell line competent of xenobiotics metabolism

Author keywords

Antihepatotoxicity; Cellular growth; Conjugating reactions; Cytochrome P 450; LDH leakage; Paracetamol toxicity; Rat hepatoma cell line

Indexed keywords

ANDROGRAPHOLIDE; CYTOCHROME P450 ISOENZYME; DEXAMETHASONE; GLUCURONOSYLTRANSFERASE; KUTKIN; PARACETAMOL; SILYMARIN; URIDINE DIPHOSPHATE GALACTOSE; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 0032803094     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(99)00072-7     Document Type: Article
Times cited : (10)

References (20)
  • 2
    • 0029002112 scopus 로고
    • Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells
    • Dai Y., Cederbaum A.I. Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells. Journal of Pharmacology and Experimental Therapeutics. 273:1995;1497-1505.
    • (1995) Journal of Pharmacology and Experimental Therapeutics , vol.273 , pp. 1497-1505
    • Dai, Y.1    Cederbaum, A.I.2
  • 3
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry. 249:1974;7130-7139.
    • (1974) Journal of Biological Chemistry , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 4
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidized and reduced glutathione in tissues
    • Hissen P.J., Hilff R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Analytical Biochemistry. 74:1976;214-226.
    • (1976) Analytical Biochemistry , vol.74 , pp. 214-226
    • Hissen, P.J.1    Hilff, R.2
  • 8
    • 0018077397 scopus 로고
    • Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse
    • Moldeus P. Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse. Biochemical Pharmacology. 27:1978;2859-2863.
    • (1978) Biochemical Pharmacology , vol.27 , pp. 2859-2863
    • Moldeus, P.1
  • 9
    • 0008642282 scopus 로고
    • Acetaminophen administration alters rate of cell replication in hepatoma cells without activation of drugs by cytochrome P450
    • Navarro C., Cohen S.D., Khairallah E.A. Acetaminophen administration alters rate of cell replication in hepatoma cells without activation of drugs by cytochrome P450. FASEB Journal. 9:1994;1216.
    • (1994) FASEB Journal , vol.9 , pp. 1216
    • Navarro, C.1    Cohen, S.D.2    Khairallah, E.A.3
  • 11
    • 0027249976 scopus 로고
    • Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine
    • Reen R.K., Jamwal D.S., Taneja S.C., Koul J.L., Dubey R.K., Wiebel F.J., Singh J. Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine. Biochemical Pharmacology. 46:1993;229-238.
    • (1993) Biochemical Pharmacology , vol.46 , pp. 229-238
    • Reen, R.K.1    Jamwal, D.S.2    Taneja, S.C.3    Koul, J.L.4    Dubey, R.K.5    Wiebel, F.J.6    Singh, J.7
  • 12
    • 0025843701 scopus 로고
    • Dealkylation of 7-methoxycoumarin as assay for measuring constitutive and phenobarbital inducible cytochrome P450 s
    • Reen R.K., Ramakanth S., Wiebel F.J., Jain M.P., Singh J. Dealkylation of 7-methoxycoumarin as assay for measuring constitutive and phenobarbital inducible cytochrome P450 s. Analytical Biochemistry. 194:1991;243-249.
    • (1991) Analytical Biochemistry , vol.194 , pp. 243-249
    • Reen, R.K.1    Ramakanth, S.2    Wiebel, F.J.3    Jain, M.P.4    Singh, J.5
  • 14
    • 0028130611 scopus 로고
    • 1-induced cytotoxicity and micronuclei formation in H4IIEC3 rat hepatoma cells
    • 1-induced cytotoxicity and micronuclei formation in H4IIEC3 rat hepatoma cells. Cancer Letters. 86:1994;195-200.
    • (1994) Cancer Letters , vol.86 , pp. 195-200
    • Singh, J.1    Reen, R.K.2    Wiebel, F.J.3
  • 15
    • 0025760042 scopus 로고
    • Induction of DNA damage by N-nitrosodiethylamine in rat hepatoma cells: Correlation with cytochrome P450-mediated aldrin epoxidase activity
    • Singh J., Roscher E. Induction of DNA damage by N-nitrosodiethylamine in rat hepatoma cells: correlation with cytochrome P450-mediated aldrin epoxidase activity. Mutagenesis. 6:1991;117-121.
    • (1991) Mutagenesis , vol.6 , pp. 117-121
    • Singh, J.1    Roscher, E.2
  • 16
    • 0019815392 scopus 로고
    • Dependence of glucuronidation rate on UDP-glucuronic acid levels in isolated hepatocytes
    • Singh J., Schwarz L.R. Dependence of glucuronidation rate on UDP-glucuronic acid levels in isolated hepatocytes. Biochemical Pharmacology. 30:1981;3252-3254.
    • (1981) Biochemical Pharmacology , vol.30 , pp. 3252-3254
    • Singh, J.1    Schwarz, L.R.2
  • 17
    • 0018603959 scopus 로고
    • A highly sensitive and rapid fluorometric assay for UDP-glucuronyltransferase using 3-hydroxybenzo(a)pyrene as substrate
    • Singh J., Wiebel F.J. A highly sensitive and rapid fluorometric assay for UDP-glucuronyltransferase using 3-hydroxybenzo(a)pyrene as substrate. Analytical Biochemistry. 98:1979;394-401.
    • (1979) Analytical Biochemistry , vol.98 , pp. 394-401
    • Singh, J.1    Wiebel, F.J.2
  • 18
    • 0026691008 scopus 로고
    • Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism- based prevention
    • Vermeulen N.P.E., Bessems J.G.M., Van de Straat R. Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism- based prevention. Drug Metabolism Reviews. 24:1992;367-407.
    • (1992) Drug Metabolism Reviews , vol.24 , pp. 367-407
    • Vermeulen, N.P.E.1    Bessems, J.G.M.2    Van De Straat, R.3
  • 20
    • 0021712399 scopus 로고
    • Expression of cytochrome P450 in rat hepatoma cells. analysis of monoclonal antibodies specific for cytochrome P450 from rat liver induced by 3-methylcholanthrene or phenobarbital
    • Wiebel F.J., Park S.S., Kiefer F., Gelboin H.V. Expression of cytochrome P450 in rat hepatoma cells. analysis of monoclonal antibodies specific for cytochrome P450 from rat liver induced by 3-methylcholanthrene or phenobarbital. European Journal of Biochemistry. 145:1984;455-462.
    • (1984) European Journal of Biochemistry , vol.145 , pp. 455-462
    • Wiebel, F.J.1    Park, S.S.2    Kiefer, F.3    Gelboin, H.V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.