Infection prophylaxy in open tibial fractures. Pefloxacine versus cefazolin-oxacilline. A 616 cases randomised study;Prophylaxie des infections dans les fractures ouvertes de jambe. Comparaison entre une dose de pefloxacine et 5 jours cefazoline-oxacilline. Etude randomisee sur 616 cas

Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur

Volumn 85, Issue 4, 1999, Pages 328-336

  Gagey, O ^d   Doyon, F ^a   Dellamonica, P ^b   Carsenti Etesse, H ^b   Desplaces, N ^c   Tancrede C ^a   Evrard, J ^c  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^c Lab Hop de la Croix St Simon ^*

^d BICÊTRE HOSPITAL   (France)

Author keywords

Antibioprophylaxis; Cefazolin; Infection; Open tibial fracture; Oxacilin; Pefloxacin; Randomised trial; Surgery

Indexed keywords

CEFAZOLIN; OXACILLIN; PEFLOXACIN;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MIXTURE; GRAM NEGATIVE INFECTION; HOSPITAL INFECTION; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OPEN FRACTURE; POSTOPERATIVE INFECTION; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; TIBIA FRACTURE; TREATMENT PLANNING; WOUND INFECTION;

ADULT; ANTI-INFECTIVE AGENTS; ANTIBIOTIC PROPHYLAXIS; CEFAZOLIN; CEPHALOSPORINS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; OXACILLIN; PEFLOXACIN; PENICILLINS; RISK FACTORS; SURGICAL WOUND INFECTION; TIBIAL FRACTURES; TIME FACTORS; WOUND INFECTION;

EID: 0032802656     PISSN: 00351040     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. BOXMA H, BROEKHUIZNE T, PATKA P, OOSTING H : Randomised controlled trial of single-dose antibiotic prophylaxis in surgical treatment of closed fractures : the Dutch Trauma Trial. Lancet, 1996, 347, 1133-1137.
2. BRAUN R, ENZLER MA, RITTMANN WW : A double blind clinical trial of prophylactic cloxacillin in open fractures. J Orthop Trauma, 1987, 1, 12-17.
3. CAUCHOIX J, LAGNEAU P, BOULEZ P : Traitement des fractures ouvertes de jambe. Résultat de 234 cas observés entre le premier janvier 1955 et le 12 juin 1964. Ann Chir, 1965, 19, 1520-1532.
4. COURT-BROWN CM : Antibiotic prophylaxis in orthopaedic surgery. Scand J Infect Dis, 1990, 70, 74-79.
5. DE LA GARZA C, CANTY-GARZA E, LOZANO JA : Cefotaxime as prophylaxis of infections in open fractures. Drug Invest, 1992, 4 suppl 2, 37-40.
6. DELLAMONICA P, BERNARD E, ETESSE H, GARRAFFO R, DRUGEON HB : Evaluation of Pefloxacin, Ofloxacin and Ciprofloxacin in the treatment of thirty-nine cases of chronic osteomyelitis. Eur J Clin Microbiol Infect Dis, 1989, 8, 1024-1030.
7. DELLINGER EP, CAPLAN ES, WEAVER LD, WERTZ MJ, DROPPERT BM, HOYT N, BRUMBACK R, BURGESS A, POKA A, BENIRSCHKE SK, LENNARD ES, LOU MA : Duration of preventive antibiotic administration for open extremity fractures. Arch Surg, 1988, 123, 333-339.
8. DESPLACE N, ACAR JF : New quinolones in the treatment of joint and bone infections :Rev Infect Dis, 1988, 10 suppl 1, 5179-5183.
9. ETESSE-CARSENTI H, GARRAFFO R, GIAUME F, BARBARIN A, LEVEAUX G, BERNARD E, LAPALUS P, ARGENSON C, DRUGEON H, DELLAMONICA P : Diffusion kinetics of pefloxacin in human bone following a single infusion. Rev Infect Dis, 1989, 11 suppl 5, 1265-1266.
10. EVRARD J, DOYON F, ACAR JF, SALORD JC, MAZAS F, FLAMANT R : Two-day cefamandole versus five-day cephazolin prophylaxis in 965 total hip replacements. Int Orthop, 1988, 12, 69-73.
11. GUSTILO RB, MENDOZA RM, WILLIAMS DN : Problems in the management of type III (severe) open fractures. A new classification of type III open fractures. J Trauma, 1984, 24, 742-746.
12. GUSTILO RB, GRUNINGER RP, DAVIS T : Classification of type III (severe) open fractures relative to treatment and results. Orthopaedics, 1987, 10, 1781-1788.
13. GUSTILO RB, MERKOW RL, TEMPLEMAN D : Current concepts review : the management of open fractures. J Bone Joint Surg, 1990, 72A, 299-304.
14. HILL C, FLAMANT R, MAZAS F, EVRARD J : Prophylactic cefazolin versus placebo in total hip replacement. Lancet, 1981, 1, 795-797.
15. MERRIT K : Factors increasing the risk of infection in patients with open fractures. J Trauma, 1988, 28, 823-827.
16. PATZAKIS MJ, WILKINS J, MOORE TM : Use of antibiotics in open tibial fractures. Clin Orthop, 1983, 178, 31-35.
17. PATZAKIS MJ, WILKINS J, MOORE TM : Considerations in reducing the infection rate in open tibial fractures. Clin Orthop, 1983b, 178, 36-41.
18. PATZAKIS MJ, WILKINS J : Factors influencing infection rate in open fracture wounds. Clin Orthop, 1989, 243, 36-40.
19. POLLARD JP, HUGHES SP, SCOTT JE, EVANS MJ, BENSON MK : Antibiotic prophylaxis in total hip replacement. Br Med J, 1979, 1, 707-709.
20. ROJEZYK M : Bacteriological findings in open fractures. Unfallheilkunde, 1981, 11, 458-462.
21. ROTH AI, FRY DE, POLK HC : Infectious morbidity in extremity fractures. J Trauma, 1986, 26, 757-761.
22. RUSSEL GG, HENDERSON R, ARNETT G : Primary or delayed closure for open tibial fractures. J Bone Joint Surg, 1990, 72B, 125-128.
23. SUEDCAMP NP, BARBEY N, VEUSKENS A, TEMPKA A, HAAS NP, HOFFMANN R, TSCHERNE H : The incidence of osteitis in open fractures : an analysis of 948 open fractures (a review of the Hannover experience). J Orthop Trauma, 1993, 7, 473-482.
24. TSCHERNE H : The management of open fractures. In : Fractures with soft tissues injuries. Ed by Tscherne, H, Gotzen L. Berlin, Springer-Verlag, 1983, pp 10-32.
25. WILKINS J, PATZAKIS MJ : Choice and duration of antibiotics in open fractures. Orthop Clin North Am, 1991, 22, 433-437.