P-glycoprotein-expressing tumor cells are resistant to anticancer drugs in human gastrointestinal cancer

Surgery Today

Volumn 29, Issue 7, 1999, Pages 591-596

  Hotta, Tsukasa ^a   Tanimura, Hiroshi ^a   Iwahashi, Makoto ^a   Tani, Masaji ^a   Tsunoda, Takuya ^a   Noguchi, Kohei ^a   Mizobata, Shizuma ^a   Arii, Kazuo ^a   Terasawa, Hiroshi ^a   Nakamori, Mikihito ^a   Yamaue, Hiroki ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Chemosensitivity test; Flow cytometry; Fresh human tumor cells; Multidrug resistance; P glycoprotein

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; FLUOROURACIL; GLYCOPROTEIN P; MITOMYCIN C; MULTIDRUG RESISTANCE PROTEIN; TETRAZOLIUM;

ARTICLE; CANCER CLASSIFICATION; CANCER STAGING; CLINICAL ARTICLE; DIGESTIVE SYSTEM CANCER; DRUG INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; PROTEIN EXPRESSION; TUMOR CELL CULTURE;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HUMANS; MITOMYCINS; P-GLYCOPROTEIN; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0032802522     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005950050472     Document Type: Article

References (30)

1. Carmichael J, Mitchell JB, Degraff WG, Gamson J, Gazdar AF, Johnson BE, Glatstein E, Minna JD (1985) Chemosensitivity testing of human lung cancer cell lines using the MTT assay. Br J Cancer 57:540-547
2. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
3. Twentyman PR, Fox NE, Rees JKH (1989) Chemosensitivity testing of fresh leukaemia cells using The MTT colorimetric assay. Br J Haematol 71:19-24
4. Campling BJ, Pym J, Baker HM, Cole SPC, Lam YM (1991) Chemosensitivity testing of small cell lung cancer using the MTT assay. Br J Cancer 63:75-83
5. Yamaue H, Tanimura H, Tsunoda T, Tani M, Iwahashi M, Noguchi K, Tamai M, Hotta T, Arii K (1991) Chemosensitivity testing with highly purified fresh human tumour cells with the MTT colorimetric assay. Eur J Cancer 27:1258-1263
6. Yamaue H, Tanimura H, Noguchi K, Hotta T, Tani M, Tsunoda T, Iwahashi M, Tamai M, Iwakura S (1992) Chemosensitivity testing of fresh human gastric cancer with highly purified tumour cells using the MTT assay. Br J Cancer 66:794-799
7. Yamaue H, Tanimura H, Nakomori M, Noguchi K, Iwahashi M, Tani M, Hotta T, Murakami K, Ishimoto K (1996) Clinical evaluation of chemosensitivity testing for patients with colorectal cancer using MTT assay. Dis Colon Rectum 39:416-422
8. Gottesman MM, Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427
9. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J, Ling V (1985) Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316:817-819
10. Roninson IB, Chin JE, Choi K, Gros P, Housman DE, Fojo A, Shen DW, Gottesman MM, Pastan I (1986) Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci USA 83:4538-4542
11. Dorr RT, Liddil JD, Trent JM, Dalton WS (1987) Mitomycin C resistant L1210 leukemia cells: association with pleiotropic drug resistance. Biochem Pharmacol 36:3115-3120
12. Eastman A (1991) Mechanisms of resistance to cisplatin. In: Ozols RF (ed) Molecular and clinical advances in anticancer drug resistance. Kluwer, Boston, pp 233-249
13. Peters GJ, van Groeningen CJ (1991) Clinical relevance of biochemical modulation of 5-fluorouracil. Ann Oncol 2:469-480
14. Soto F, Planells-Cases R, Canaves JM, Ferrer-Montiel AV, Aleu J, Gamarro F, Castanys S, Gonzalez-Ros JM, Ferragut JA (1993) Possible coexistence of two independent mechanisms contributing to anthracycline resistance in leukaemia P388 cells. Eur J Cancer 29A:2144-2150
15. Goldstein LJ, Galski H, Fojo A, Willingham M, Lai SL, Gazdar A, Pirker R, Green A, Crist W, Brodeur GM, Lieber M, Cossman J, Gottesman MM, Pastan I (1989) Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst 81:116-124
16. Clifford SC, Thomas DJ, Neal DE, Lunec J (1994) Increased mdrl gene transcript levels in high-grade carcinoma of the bladder determined by quantitative PCR-based assay. Br J Cancer 69:680-686
17. Volm M, Mattern J, Samsel B (1991) Overexpression of P-glycoprotein and glutathione S-transferase-π in resistant non-small cell lung carcinomas of smokers. Br J Cancer 64:700-704
18. Kartner N, Evernden-Porelle D, Bradley G, Ling V (1985) Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316:820-823
19. Leonce S, Pierre A, Anstett M, Perez V, Genton A, Bizzari JP, Atassi G (1992) Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying p-glycoprotein-mediated multidrug resistance. Biochem Pharmacol 44:1707-1715
20. Thierry AR, Jorgensen TJ, Forst D, Belli JA, Dritschilo A, Rahman A (1989) Multidrug resistance in Chinese hamster cells: effect of liposome-encapsulated doxorubicin. Cancer Commun 1:311-316
21. Tamai M, Tanimura H, Yamaue H, Iwahashi M, Tsunoda T, Tani M, Noguchi K, Mizobata S, Hotta T, Arii K, Terasawa H (1995) Clinical significance of quantitative analysis of carcinoembryonic antigen assessed by flow cytometry in fresh human gastric cancer cells. Cancer Lett 90:111-117
22. Dulhanty AM, Whitmore GF (1991) Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase. Cancer Res 51:1860-1865
23. Hoban PR, Walton MI, Robson CN, Godden J, Stratford IJ, Workman P, Harris AL, Hickson ID (1990) Decreased NADPH: cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions. Cancer Res 50:4692-4697
24. Gustafson DL, Pritsos CA (1992) Bioactivation of mitomycin C by xanthine dehydrogenase from EMT 6 mouse mammary carcinoma tumors. J Natl Cancer Inst 84:1180-1185
25. Singh SV, Xu BH, Maurya AK, Mian AM (1992) Modulation of mitomycin C resistance by glutathione transferase inhibitor ethacrynic acid. Biochim Biophys Acta 1137:257-263
26. Dulhanty AM, Li M, Whitmore GF (1989) Isolation of Chinese hamster ovary cell mutants deficient in excision repair and mitomycin C bioactivation. Cancer Res 49:117-122
27. Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y (1981) Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41:1967-1972
28. Slater LM, Sweet P, Stupecky M, Gupta S (1986) Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro. J Clin Invest 77:1405-1408
29. Hotta T, Tanimura H, Yamaue H, Iwahashi M, Tani M, Tsunoda T, Tamai M, Noguchi K, Mizobata S, Arii K, Terasawa H (1996) Tamoxifen circumvents the multidrug resistance in fresh human gastrointestinal cancer cells. J Surg Res 66:31-35
30. Hotta T, Tanimura H, Yamaue H, Iwahashi M, Tani M, Tsunoda T, Tamai M, Noguchi K, Mizobata S, Arii K, Terasawa H (1997) Modulation of multidrug resistance by cepharanthine in fresh human gastrointestinal tumor cells. Oncology 54:153-157