The use of extracellular lactate as an oxidative substrate in the oxygen-limited frog

Respiration Physiology

Volumn 116, Issue 2-3, 1999, Pages 171-179

  Donohoe, Paul H ^a,b   Boutilier, Robert G ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amphibian, frog; Hibernation, anaerobic metabolism; Hypoxia, hibernation; Lactic acid, shuttle, hypoxic hibernation; Metabolisim, anaerobic, hibernating

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; LACTIC ACID;

ANAEROBIC METABOLISM; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FROG; HIBERNATION; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL;

ACID-BASE EQUILIBRIUM; ANIMALS; ANOXIA; EXTRACELLULAR SPACE; HYDROGEN-ION CONCENTRATION; LACTIC ACID; LIVER GLYCOGEN; MALE; MUSCLE, SKELETAL; MYOCARDIUM; OXIDATION-REDUCTION; PHOSPHORIC ACID ESTERS; RANA TEMPORARIA; SKIN;

EID: 0032802479     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(99)00036-5     Document Type: Article

References (26)

1. Bergmeyer, H.U., 1974. Methods of Enzymatic Analysis. Academic, New York.
2. Boutilier, R.G., Dobson, G., Hoeger, U., Randall, D.J., 1988. Acute exposure to graded levels of hypoxia in rainbow trout Salmo gairdneri. Respir. Physiol. 71, 69-82.
3. Boutilier, R.G., Glass, M.L., Heisler, N., 1986. The relative distribution of pulmocutaneous blood flow in Rana catesbeiana: effects of pulmonary or cutaneous hypoxia. J. Exp. Biol. 126, 33-39.
4. Boutilier, R.G., Lantz, C.J., 1989. The effects of forced and voluntary diving on plasma catecholamines and erythrocyte pH in the aquatic anuran, Xenopus laevis. Exp. Biol. 48, 83-88.
5. Boutilier, R.G., Stiffler, D.F., Toews, D., 1992. Exchange of respiratory gases, ions and water in amphibious and aquatic amphibians. In: Feder, M.E., Burggren, W.W. (Eds.), Environmental Physiology of the Amphibians. University of Chicago Press, Chicago/London, pp. 81-124.
6. Boutilier, R.G., Donohoe, P.H., Tattersall, G.J., West, T.G., 1997. Hypometabolic homeostasis in overwintering aquatic amphibians. J. Exp. Biol. 200, 387-400.
7. Bradford, D.F., 1983. Winterkill, oxygen relations, and energy metabolism of a submerged dormant amphibian, Rana mucosa. Ecology 64, 1171-1183.
8. Brooks, G.A., 1985. Lactate: Glycolytic end product and oxidative substrate during sustained exercise in mammals - the 'lactate shuttle'. In: Gilles, R. (Ed.), Circulation, Respiration and Metabolism. Springer-Verlag, Berlin, pp. 208-218.
9. Donohoe, P.H., West, T.G., Boutilier, R.G., 1998. Respiratory, metabolic and acid-base correlates of aerobic metabolic rate reduction in overwintering frogs. Am. J. Physiol. 274, R704-R710.
10. Donohoe, P.H., Boutilier, R.G., 1998. The protective effects of metabolic rate depression in hypoxic cold submerged frogs. Respir. Physiol. 111, 325-336.
11. Flanigan, J.E., Withers, P.C., Guppy, M., 1991. In vitro metabolic depression of tissues from the aestivating frog Neobatrachus pelobatoides. J. Exp. Biol. 161, 273-283.
12. Fournier, P.A., Guderley, H., 1993. Muscle: the predominant glucose-producing organ in the leopard frog during exercise. Am. J. Physiol. 264, R239-R243.
13. Hochachka, P.W., Mommsen, T.P., 1983. Protons and anaerobiosis. Science 219, 1391-1397.
14. Jackson, D.C., Heisler, N., 1983. Intracellular and extracellular acid-base and electrolyte status of submerged anoxic turtles at 3°C. Respir. Physiol. 53, 187-201.
15. Lutz, P.L., 1988. Interaction between hypometabolism and acid-base balance. Can. J. Zool. 67, 3018-3023.
16. Maginnis, L.A., Song, Y.K., Reeves, R.B., 1980. Oxygen equilibria of ectotherm blood containing multiple haemoglobins. Respir. Physiol. 42, 329-343.
17. Pasanen, S., Koskela, P., 1974. Seasonal and age variation in the metabolism of the common frog, Rana temporaria L., in northern Finland. Comp. Biochem. Physiol. 47, 635-654.
18. Passonneau, J.V., Lowry, O.H., 1993. Enzymatic analysis: a practical guide. Humana Press, Otowa.
19. Pinder, A.W., 1987. Cutaneous diffusing capacity increases during hypoxia in cold submerged frogs Rana catesbeiana. Respir. Physiol. 70, 85-95.
20. Pinder, A.W., Storey, K.B., Ultsch, G.R., 1992. Exchange of respiratory gases, ions and water in amphibious and aquatic amphibians. In: Feder, M.E., Burggren, W.W. (Eds.), Environmental Physiology of the Amphibians. University of Chicago Press, Chicago/London, pp. 250-274.
21. CO2 after metabolic inhibition by fluoride and nitriloacetic acid. Respir. Physiol. 81, 255-274.
22. Sibley, D.R., Lefkowitz, R.J., 1985. Molecular mechanisms of receptor desensitization using the β-adrenergic coupled anedylate cyclase system as a model. Nature 317, 124-129.
23. Stiffler, D.F., 1988. Cutaneous exchange of ions in lower vertebrates. Am. Zool. 28, 1019-1029.
24. Storey, K.B., Storey, J.M., 1990. Metabolic rate depression and biochemical adaptation in anaerobiosis, hibernation and estivation. Q. Rev. Biol. 65, 145-174.
25. Wasser, J.S., Freund, E.V., Gonzalez, L.A., Jackson, D.C., 1990. Force and acid-base state of turtle cardiac tissue exposed to combined anoxia and acidosis. Am. J. Physiol. 259, R15-R20.
26. Wegener, G., Krause, U., 1993. Environmental and exercise anaerobiosis in frogs. In: Hochachka, P.W., Lutz, P.L., Sick, T., Rosenthal, M., van den Thillart, G. (Eds.), Surviving Hypoxia: Mechanisms of Control and Adaptation. CRC Press, Boca Raton, pp. 217-236.