Mechanical function and substrate oxidation in the neonatal pig heart subjected to pacing-induced tachycardia

Molecular Genetics and Metabolism

Volumn 66, Issue 3, 1999, Pages 212-223

  Ascuitto, Robert J ^a   Joyce, James J ^a   Ross Ascuitto, Nancy T ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Heart; Metabolism; Neonatal; Tachycardia

Indexed keywords

GLUCOSE; IODOACETIC ACID; PALMITIC ACID; PYRUVIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; GLUCOSE OXIDATION; GLYCOLYSIS; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HEART PACING; HEART RATE; HEART VENTRICLE COMPLIANCE; HEART VENTRICLE FUNCTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SWINE; TACHYCARDIA;

ANIMALIA; SUS SCROFA;

EID: 0032802398     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.1998.2791     Document Type: Article

References (44)

1. Neely J R, Morgan H E. Relationships between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu Rev Physiol. 36:1974;413-459.
2. Lopaschuk G D, Spafford M A, Marsh D R. Glycolysis is predominant source of myocardial ATP production immediately after birth. Am J Physiol. 261:1991;H1698-H1705.
3. Werner J C, Whitman V, Fripp R R, Schuler H G, Morgan H E. Carbohydrate metabolism in isolated, working newborn pig heart. Am J Physiol. 241:1981;E364-E371.
4. Dawes G S, Mott J C, Shelley H J. The importance of cardiac glycogen for the maintenance of life in foetal lambs and newborn animals during anoxia. J Physiol (Lond). 146:1959;516-538.
5. Hoerter J A, Opie L H. Perinatal changes in glycolytic function in response to hypoxia in the incubated or perfused rat heart. Biol Neonate. 33:1978;144-161.
6. Neely J R, Liedtke A J, Whitmer J T, Rovetto M J. Relationship between coronary flow and adenosine triphosphate production from glycolysis and oxidative metabolism. Recent Adv Stud Card Struct Metab. 8:1975;301-321.
7. Werner J C, Whitman V, Vary T C, Fripp R R, Musselman J, Schuler H G. Fatty acid and glucose utilization in isolated, working newborn pig hearts. Am J Physiol. 244:1983;E19-E23.
8. Lopaschuk G D, Spafford M A. Energy substrate utilization by isolated working hearts from newborn rabbits. Am J Physiol. 258:1990;H1274-H1280.
9. Liedtke A J, Nellis S, Neely J R. Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine. Circ Res. 43:1978;652-661.
10. Webb J L. Iodoacetate and iodoacetamide. 1966;Academic Press, New York. p. 1-283.
11. Pirolo J S, Allen D G. Assessment of techniques for preventing glycolysis in cardiac muscle. Cardiovasc Res. 20:1986;837-844.
12. Ascuitto R J, Ross-Ascuitto N T, Chen V, Downing S E. Ventricular function and fatty acid metabolism in the neonatal pig heart. Am J Physiol. 256:1989;H9-H15.
13. Eur Heart J. 1:1980.
14. Pierce G N, Philipson K D. Binding of glycolytic enzymes to cardiac sarcolemma and sarcoplasmic reticular membranes. J Biol Chem. 260:1985;6862-6870.
15. 2+. Circ Res. 77:1995;88-97.
16. Ross-Ascuitto N, Ascuitto R, Chen V, Downing S E. Negative inotropic effects of amrinone in the neonatal pig heart. Circ Res. 61:1987;847-852.
17. Weiss J L, Frederiksen J W, Weisfeldt M L. Hemodynamic determinants of the time course of fall in canine left ventricular pressure. J Clin Invest. 58:1976;751-760.
18. Ascuitto R J, Ross-Ascuitto N T, Kydon D W, Waddell A E, McDonough K H. Mechanical and metabolic characterization of ischemic contracture in the neonatal pig heart. Pediatr Res. 38:1995;228-236.
19. Neely J R, Denton R M, England P J, Randle P J. The effects of increased heart work on the tricarboxylate cycle and its interactions with glycolysis in the perfused rat heart. Biochem J. 128:1972;147-159.
20. Lowry, O, H, Passoneau, J, V, A Flexible System of Enzymatic Analysis, New York, Academic Press, 199, 200, 1972.
21. Vogel W M, Apstein C S, Briggs L L, Gaasch W H, Ahn J. Acute alterations in left ventricular diastolic chamber stiffness. Circ Res. 51:1982;465-478.
22. Ascuitto R J, Ross-Ascuitto N T, Waddell A E, Kadowitz P J. Contractile and coronary vascular effects of pituitary adenylate cyclase activating polypeptide in neonatal pig hearts. Cardiovasc Res. 31:1996;153-159.
23. Tede N H, Ross-Ascuitto N T, Ascuitto R J. Mechanical function and palmitate oxidation with oxygen supply-demand mismatch in neonatal pig hearts. Pediatr Res. 43:1998;27A.
24. Sicard R E, Werner J C. Insulin responsiveness of neonatal pig myocardium. Biol Neonate. 56:1989;101-108.
25. Freeman G L, Little W C, O'Rourke R A. Influence of heart rate on left ventricular performance in conscious dogs. Circ Res. 61:1987;455-464.
26. Frederiksen J W, Weiss J L, Weisfeldt M L. Time constant of isovolumic pressure fall: determinants in the working left ventricle. Am J Physiol. 235:1978;H701-H706.
27. Mahony L. Maturation of calcium transport in cardiac sarcoplasmic reticulum. Pediatr Res. 24:1988;639-643.
28. Kaufman T M, Horton J W, White D J, Mahony L. Age-related changes in myocardial relaxation and sarcoplasmic reticulum function. Am J Physiol. 259:1990;H309-H316.
29. Momomura S-I, Iizuka M, Serizawa T, Sugimoto T. Separation of rate of left ventricular relaxation from chamber stiffness in rats. Am J Physiol. 255:1988;H1468-H1475.
30. Smith V E, Zile M R. Relaxation and diastolic properties of the heart. Fozzard H A, Haber E A, Jennings R B, Katz A M, Morgan H E. The Heart and Cardiovascular System. 1992;1353-1366 Raven Press, New York.
31. Smith V E, Weisfeldt M L, Katz A M. Relaxation and diastolic properties of the heart. Fozzard H A, Haber E A, Jennings R B, Katz A M, Morgan H E. The Heart and Cardiovascular System. 1986;803-817 Raven Press, New York.
32. Rogers R L, Black S, Katz S, McNeill J H. Thyroidectomy of SHR: effects on ventricular relaxation and on SR calcium uptake activity. Am J Physiol. 250:1986;H861-H865.
33. Portman M A, Ning X H. Myocardial energy metabolism in the newborn lamb in vivo during pacing induced changes in oxygen consumption. Pediatr Res. 37:1995;182-188.
34. Broderick T L, Quinney A, Lopaschuk G D. Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart. J Biol Chem. 267:1992;3758-3763.
35. Randle P J, Tubbs P K. Carbohydrate and fatty acid metabolism. Berne R M, Speralakis N, Geiger S R. Handbook of Physiology - The Cardiovascular System. Vol I. The Heart. 1979;805-844 Am Physiol Soc, Bethesda.
36. Werner J C, Sicard R E, Schuler H G. Palmitate oxidation by isolated working fetal and newborn pig hearts. Am J Physiol. 256:1989;E315-E321.
37. Ascuitto R J, Ross-Ascuitto N T. Substrate metabolism in the developing heart. Sem in Perinatol. 20:1996;542-563.
38. Walker P M, Mickle A G, Tanner W R, Harding R, Romaschin A D. Decreased uptake of exogenous substrates following graded muscle stimulation. Am J Physiol. 246:1984;H690-H695.
39. Ascuitto R J, Ross-Ascuitto N T, Ramage D, McDonough K H. Mechanical function and fatty acid oxidation in the neonatal pig heart with ischemia and reperfusion. J Dev Physiol. 14:1990;249-257.
40. McGowen F X, Lee F A, Chen V, Downing S E. Oxidative metabolism and mechanical function in reperfused neonatal pig heart. J Mol Cell Cardiol. 24:1992;831-840.
41. Wittels B, Bressler R. Lipid metabolism in the newborn heart. J Clin Invest. 44:1965;1639-1646.
42. Warshaw J B, Terry M L. Cellular energy development during fetal development. II. Fatty acid oxidation by the developing heart. J Cell Biol. 44:1970;354-360.
43. Owen P, Dennis S, Opie L H. Glucose flux regulates onset of ischemic contracture in globally underperfused rat hearts. Circ Res. 66:1990;344-354.
44. 2+. Am J Physiol. 264:1993;H670-H678.