Low-dose mercuric chloride induces resistance in brown norway rats to further mercuric chloride by up-regulation of interferon-γ

Scandinavian Journal of Immunology

Volumn 50, Issue 2, 1999, Pages 195-201

  Szeto, C C ^a   Gillespie, K M ^a   Mathieson, Peter W ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 4; MERCURIC CHLORIDE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; DOSE RESPONSE; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; GENE EXPRESSION; INTERFERON TYPE II; MALE; MERCURIC CHLORIDE; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED BN; SPLEEN; UP-REGULATION;

EID: 0032802350     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1999.00584.x     Document Type: Article

References (27)

1. 1 Hultman P, Enestrom S. Mercury induced antinuclear antibodies in mice: characterization and correlation with renal immune complex deposits. Clin Exp Immunol 1988;71:269-74.
2. 2 Bariety J, Druet P, Laliberte F, Sapin C. Glomerulonephritis with gamma and beta IC-globulin deposits induced in rats by mercuric chloride. Am J Pathol 1971;65:293-302.
3. 3 Mathieson PW. Mercuric chloride-induced autoimmunity. Autoimmunity 1992;13:243-7.
4. 4 Mathieson PW, Thiru S, Oliveira DBG. Mercuric chloride-treated Brown Norway rats develop widespread tissue injury including necrotizing vasculitis. Lab Invest 1992;67:121-9.
5. 2 induces nonspecific immuno-suppression in Lewis rats. Eur J Immunol 1987;17:49-54.
6. 6 Pelletier L, Galceran M, Pasquier R et al. Down modulation of Heymann's nephritis by mercuric chloride. Kidney Int 1987;32:227-32.
7. 2-induced down-modulation of the disease. Eur J Immunol 1988;18:243-7.
8. 8 Bowman C, Mason DW, Pusey CD, Lockwood CM. Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the Brown Norway rat. A role for T suppressor cells. Eur J Immunol 1984;14:464-70.
9. 9 Mathieson PW, Stapleton KJ, Oliveira DBG, Lockwood CM. Immunoregulation of mercuric chloride-induce autoimmunity in Brown Norway rats: a role for CD8+ T cells revealed by in vivo depletion studies. Eur J Immunol 1991;21:2105-9.
10. 10 Chornczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Analyt Biochem 1987;162:156-9.
11. 11 Gillespie KM, Qasim EJ, Tibbatts LM, Thiru S, Oliveira DBG, Mathieson PW. Interleukin-4 gene expression in mercury-induced autoimmunity. Scand J Immunol 1995;41:268-72.
12. 12 Gillespie KM, Saoudi A, Kuhn J et al. Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains. Eur J Immunol 1996;26:2388-92.
13. 13 McKnight AJ, Barclay AN, Mason DW. Molecular cloning of rat interleukin-4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells. Eur J Immunol 1991;21:1187-94.
14. 14 Mathieson PW, Gillespie KM. Cloning of a partial cDNA for rat interleukin-12 (IL-12) and analysis of IL-12 expression in vivo. Scand J Immunol 1996;44:11-14.
15. 15 Conti B, Jahng JW, Tinti C, Son JH, Joh TH. Induction of interferon-γ inducing factor in the adrenal cortex. J Biol Chem 1997;272:2035-7.
16. 16 Tournade H, Pelletier L, Guery JC et al. Experimental gold-induced autoimmunity. Nephrol Dial Transplant 1991;6:621-30.
17. 17 Goldman M, Druet P, Gleichmann E. Th2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol Today 1991;12:223-7.
18. 18 Mathieson PW. Mercury: God of Th2 cells? Clin Exp Immunol 1995; 102:229-30.
19. 19 Kermarrec N, Dubay C, de Gouyon B et al. Serum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat. Genomics 1996;31: 111-14.
20. 20 Bellon B, Capron M, Druet E et al. Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes. Eur J Clin Invest 1982;12:127-33.
21. 21 Castedo M, Pelletier L, Rossert J, Pasquier R, Villarroya H, Druet P. Mercury-induced autoreactive anti-class II T-cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8+ antiergotypic cells in Lewis rats. J Exp Med 1993;177:881-9.
22. 22 Chan SH, Perussia B, Gupta JW et al. Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responding cells and synergy with other inducers. J Exp Med 1991;173:869-79.
23. 23 Chan SH, Kobayashi M, Santoi D, Perussia B, Trinchieri G. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J Immunol 1992;148:92-8.
24. 24 Ushio S, Namba M, Okura T et al. Cloning of the cDNA for human IFN-gamma-inducing factor expression in Escherichia coli and studies on the biologic activities of the protein. J Immunol 1996;156:4274-9.
25. 25 Bazan JF, Timans JC, Kastelein RA. A newly defined interleukin-1? Nature 1996;378:88-91.
26. 26 Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 1997;185:817-24.
27. 27 Gollob JA, Kawasaki H, Ritz J. Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur J Immunol 1997;27:647-52.