Regulation of erythropoietin gene expression depends on two different oxygen-sensing mechanisms

Molecular Genetics and Metabolism

Volumn 67, Issue 2, 1999, Pages 113-117

  Daghman, Nureddin A ^a   McHale, Cliona M ^a   Savage, Geraldine M ^a   Price, Susan ^a   Winter, Paul C ^a   Maxwell, A Peter ^b   Lappin, Terence R J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b BELFAST CITY HOSPITAL   (United Kingdom)

Author keywords

Carbon monoxide; Desferrioxamine; Erythropoietin; Iron; Oxygen sensing

Indexed keywords

CARBON MONOXIDE; COBALT CHLORIDE; DEFEROXAMINE; ERYTHROPOIETIN; HEMOPROTEIN; IRON CHELATING AGENT; OXYGEN; REACTIVE OXYGEN METABOLITE;

ARTICLE; BIOSENSOR; CELL HYPOXIA; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; IRON CHELATION; OXYGEN TENSION; PRIORITY JOURNAL;

EID: 0032801984     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.1999.2851     Document Type: Article

References (19)

1. Krantz S. Erythropoietin. Blood. 77:1991;419-434.
2. Embury S H, Garcia J F, Mohandas N, Pennathur-Das R, Clark M R. Effects of oxygen inhalation on endogenous erythropoietin kinetics, erythropoiesis, and properties of blood cells in sickle-cell anemia. N Engl J Med. 311:1984;291-295.
3. Cotes P M. Physiological studies of erythropoietin in plasma. Jelkmann W, Gross A J. Erythropoietin. 1989;57-79 Springer, Berlin.
4. Bunn H F, Poyton R O. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev. 76:1996;839-885.
5. Goldberg M A, Dunning S P, Bunn H F. Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science. 242:1988;1412-1415.
6. Goldwasser E, Jacobson L O, Fried W, Plzak L. Mechanism of the erythropoietic effect of cobalt. Nature. 125:1957;1085-1086.
7. Beru N, McDonald J, Lacombe C, Goldwasser E. Expression of the erythropoietin gene. Mol Cell Biol. 6:1986;2571-2575.
8. Görlach A, Jelkmann W, Hancock J T, Jones S A, Jones O TG, Acker H. Photometric characteristics of heme proteins in erythropoietin producing hepatoma cells (HepG2). Biochem J. 290:1993;771-776.
9. Fandrey J, Frede S, Jelkmann W. Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J. 303:1994;507-510.
10. Wang G L, Semenza G L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction. Blood. 82:1993;3610-3615.
11. Gleadle J M, Ebert B L, Firth J D, Ratcliffe P J. Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am J Physiol. 268:1995;C1362-C1368.
12. Ho V T, Bunn H F. Effects of transition metals on the expression of the erythropoietin gene: Further evidence that the oxygen sensor is a heme protein. Biochem Biophys Res Commun. 223:1996;175-180.
13. Kling P J, Dragsten P R, Roberts R A, Santos B D, Brooks D J, Hedlund B E, Taete R. Iron deprivation increases erythropoietin production in vitro, in normal subjects and patients with malignancy. Br J Haematol. 95:1996;241-248.
14. Fandrey J, Frede S, Ehleben W, Porwol T, Acker H, Jelkmann W. Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species. Kidney Int. 51:1997;492-496.
15. Lappin T RJ, Elder G E, Taylor T, McMullin M F, Bridges J M. Comparison of the mouse spleen cell assay and a radioimmunoassay for the measurement of serum erythropoietin. Br J Haematol. 70:1988;117-120.
16. Leonard M, Brice M, Engel J D, Papayannopoulou T. Dynamics of GATA transcription factor expression during erythroid differentiation. Blood. 82:1993;1071-1079.
17. Goldwasser E, Alibali P, Gardner A. Differential inhibition by iodonium compounds of induced erythropoietin expression. J Biol Chem. 270:1995;2628-2629.
18. Gleadle J M, Ebert B L, Ratcliffe P J. Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia: Implications for the mechanism of oxygen sensing. Eur J Biochem. 234:1995;92-95.
19. Ehleben W, Porwol T, Fandrey J, Kummer W, Acker H. Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in Hep G2 cells. Kidney Int. 51:1997;483-491.