Purification and characterization of two recombinant human granulocyte colony-stimulating factor glycoforms: Pharmacokinetic and activity studies of single-dose administration in mice

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 11, Issue 2, 1999, Pages 117-128

  Rotondaro, Luigi ^a   De Paolis, Enrico ^b   Ferrero, Dario ^c   D'Alatri, Laura ^a   Raucci, Giuseppe ^a   Fabbri, Armando ^b   Gerwig, Gerrit J ^d   Kamerling, Johannis P ^d   Mariani, Maurizio F ^e   Mele, Antonio ^a   De Santis, Rita ^a  

^a Menarini Ricerche SpA   (Italy)

^b SUBBIOTEC SrI   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UTRECHT UNIVERSITY   (Netherlands)

^e Research Toxicology Centre   (Italy)

Author keywords

Activity; Glycoform; Granulocyte colony stimulating factor; Neutrophil; Pharmacokinetics; Recombinant

Indexed keywords

RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CARBOHYDRATE ANALYSIS; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STRUCTURE; INTRAVENOUS DRUG ADMINISTRATION; ISOELECTRIC FOCUSING; LEUKOCYTE COUNT; MALE; MOUSE; NEUTROPHILIA; NONHUMAN; PROTEIN ANALYSIS; PROTEIN PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; ESCHERICHIA COLI;

EID: 0032801935     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02915805     Document Type: Article

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