Size analysis of a pressurized metered dose inhaler-delivered suspension formulation by the API aerosizer time-of-flight aerodynamic particle size analyzer

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 12, Issue 4, 1999, Pages 255-264

  Mitchell, Jolyon P ^a   Nagel, Mark W ^a   Archer, Allan D ^a  

^a TRUDELL MEDICAL INTERNATIONAL   (Canada)

Author keywords

Aerodynamic size; Metered dose inhaler; Particle size analysis; Suspension formulation

Indexed keywords

BUDESONIDE;

ANALYZER; ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; INHALATIONAL DRUG ADMINISTRATION; MEASUREMENT; METERED DOSE INHALER; PARTICLE SIZE; SUSPENSION;

EID: 0032801360     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.1999.12.255     Document Type: Article

References (18)

1. Dahneke, B. 1973. Aerosol beam spectrometry. Nat. Phys. Sci. 244:54-55.
2. Baron, P.A., MK. Mazumder, and Y.S. Cheng. 1993. Direct reading techniques using optical particle detection. In K. Willeke, and P.A. Baron, eds. Aerosol Measurement. Van Nostrand Reinhold, New York, 381-409.
3. Mitchell, J.P., and M.W. Nagel. 1997. Medical aerosols: Techniques for particle size evaluation. Particle Sci. Technol. 15:217-241.
4. Niven, R. 1993. Aerodynamic particle size testing using a time-of-flight aerosol beam spectrometer. Pharm. Technol. 17:72-78.
5. Mitchell, J.P., and M.W. Nagel. 1999. Time-of-flight aerodynamic particle size analyzers: Their use and limitations for the evaluation of medical aerosols. J. Aerosol Med. 12:217-240.
6. Mitchell, J.P., and M.W. Nagel. 1996. An assessment of the API Aerosizer® for the real time measurement of medical aerosols from pressurized metered dose inhaler (pMDI) systems. Aerosol Sci. Technol. 25: 411-123.
7. Mitchell, J.P., M.W. Nagel, and Y.S. Cheng. 1999. Use of the Aerosizer® aerodynamic particle size analyzer to characterize aerosols from pressurized metered-dose inhalers (pMDIs) for medication delivery. J. Aerosol Sci. 30:467-477.
8. Cheng, Y.S., E.B. Barr, I.A. Marshall, and J.P. Mitchell. 1993. Calibration and performance of an API Aerosizer®. J. Aerosol Sci. 24:501-514.
9. United States Pharmacopeia. 1995. Physical tests and determinations. Aerosols. United States Pharmacopeia 23:1760-1767.
10. Marple, V.A., and K. Willeke. 1976. Inertial impactors: Theory, design and use. In B.Y.H. Liu, ed. Fine Particles. Academic Press, New York, 411-466.
11. Kim, C.S., D. Trujillo, and M.A. Sackner. 1985. Size aspects of metered-dose inhaler aerosols. Am. Rev. Respir. Dis. 132:137-142.
12. Dolovich, M.B., and M.T. Newhouse. 1993. Aerosols: Generation, methods of administration and therapeutic applications in asthma. In E. Middleton, C.E. Reed, E.F. Ellis, N.F. Adkinson, J.W. Yunginger, and W.W. Busse, eds. Allergy: Principles and Practice. Mosby Year Book, St. Louis, 712-739.
13. Pulmicort®: 200 μg/dose. 1996. Package insert. Laboratories Astra, Nanterre, France.
14. Moren, F., and J. Andersson. 1980. Fraction of dose exhaled after administration of pressurized aerosols. Int. J. Pharm. 6:295-300.
15. Barry, P.W., and C. O'Callaghan. 1996. Inhalational drug delivery from seven different spacer devices. Thorax. 51:835-840.
16. Ahrens, R., C. Lux, T. Bahl, and S.-H. Han. 1995. Choosing the metered-dose inhaler spacer or holding chamber that matches the patient's need: Evidence that the specific drug being delivered is an important consideration. J. Allergy Clin. Immunol. 96:288-294.
17. Olson, B.A., V.A. Marple, J.P. Mitchell, and M.W. Nagel. 1998. Development and calibration of a low flow version of the Marple Miller Impactor (MMI™). Aerosol Sci. Technol. 29:307-314.
18. Mitchell, J.P., M.W. Nagel, V.A. Marple, and B.A. Olson. 1997. A low flow version of the Marple-Miller impactor (MMI™) for the evaluation of drug delivery devices that may be used by infants and small children. In Drug Delivery to the Lungs VIII. UK Aerosol Society, London, 54-57.