A novel model of aspiration in young and old guinea-pigs using LacZ gene transduction of adenovirus vector

British Journal of Anaesthesia

Volumn 83, Issue 2, 1999, Pages 296-301

  Teramoto, S ^a   Matsui, H ^a   Ohga, E ^a   Ishii, T ^a   Matsuse, T ^a   Ouchi, Y ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Age factors; Airway, reflexes; Anaesthetics volatile, halothane; Guinea pig; Infection, viral

Indexed keywords

HALOTHANE; OXYGEN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPIRATION; CONTROLLED STUDY; GENE EXPRESSION; GENERAL ANESTHESIA; GENETIC TRANSDUCTION; GUINEA PIG; MALE; NONHUMAN; OROPHARYNX; PRIORITY JOURNAL; REFLEX; UPPER RESPIRATORY TRACT;

EID: 0032801332     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/83.2.296     Document Type: Article

References (33)

1. Bluman LG, Mosca L, Newman N, Simon DG. Preoperative smoking habits and postoperative pulmonary complications. Chest 1998; 113: 883-9
2. Brooks-Brunn JA. Predictors of postoperative pulmonary complications following abdominal surgery. Chest 1998; 113: 883-9
3. Gamsu G, Singer MM, Vincent HH, Berry S, Nadel JA. Postoperative impairment of mucus transport in the lung. Am Rev Respir Dis 1976; 114: 673-9
4. Murphy PJ, Langton JA, Barker P, Smith G. Effect of oral diazepam on the sensitivity of upper airway reflexes. Br J Anaesth 1993; 70: 131-4
5. Nishino T, Kohchi T, Shirahata M, Yonezawa T. Effects of increasing depths of anaesthesia on phrenic and hypoglossal nerve activity during the swallowing reflex in cats. Br J Anaesth 1985; 57: 208-13
6. 2O in oxygen. Anesthesiology 1987; 67: 995-8
7. Brock-Utne JG, Winning TJ, Rubin J, Kingston HGG. Laryngeal incompetence during neuroleptanalgesia in combination with diazepam. Br J Anaesth 1976; 48: 699-701
8. Rubin J, Brock-Utne JG, Greenberg M, Bortz J, Dowing JW. Laryngeal incompetence during experimental 'relative analgesia' using 50% nitrous oxide in oxygen. Br J Anaesth 1977; 49; 1005-8
9. Cervin A, Lindberg S. Changes in mucociliary activity may be used to investigate the airway-irritating potency of volatile anaesthetics. Br J Anaesth 1998; 80: 475-80
10. Gyi A, O'Callaghan C, Langton JA. Effect of halothane on cilia beat frequency of ciliated human respiratory epithelium in vitro. Br J Anaesth 1994; 73: 507-10
11. Harkness GA, Bentley DW, Roghmann KJ. Risk factors for nosocomial pneumonia in the elderly. Am J Med 1990; 89: 457-63
12. Feinberg MJ, Knebl J, Tully J, Segall L. Aspiration and the elderly. Dysphagia 1990; 5: 1289-93
13. Kikuchi R, Watabe N, Konno T, Mishina N, Sekizawa K, Sasaki H. High incidence of silent aspiration in elderly patients with community-acquired pneumonia. Am J Respir Crit Care Med 1994; 150: 251-3
14. Matsuse T, Oka T, Kida K, Fukuchi Y. Importance of diffuse aspiration bronchiolitis caused by chronic occult aspiration in the elderly. Chest 1996; 110: 1289-93
15. Teramoto S, Fukuchi Y, Ouchi Y. Oxygen desaturation on swallowing in patients with stroke: what does it mean? Age Ageing 1996; 25: 333-4
16. Pontopiddan H, Beecher HK. Progressive loss of protective reflexes in the airway with the advancing age. JAMA 1960; 174: 2209-13
17. Erskine RJ, Murphy PJ, Langton JA, Smith G. Effect of age on the sensitivity of upper airway reflexes. Br J Anaesth 1993; 73: 574-5
18. Shaker R, Ren J, Zamir Z, Sarna A, Liu J, Sui Z. Effect of aging, position, and temperature on the threshold volume triggering pharyngeal swallows. Gastroenterology 1994; 107: 396-402
19. Newnham DM, Hamilton JC. Sensitivity of the cough reflex in young and elderly subjects. Age Ageing 1997; 26: 185-8
20. Teramoto S, Johnson LG, Huang W, Leigh MW, Boucher RC. Effect of adenoviral vector infection on cell proliferation in cultured primary human airway epithelial cells. Hum Gene Ther 1995; 6: 1045-53
21. Teramoto S, Matsuse T, Ohga E, Nagase T, Fukuchi Y, Ouchi Y. Kinetics of adenovirus-mediated gene transfer to human lung fibroblasts. Life Sci 1997; 61: 891-7
22. Teramoto S, Ito H, Ouchi Y. Variables affecting the transduction efficiency of adenovirus vectors in bovine aortic endothelial cells. Thromb Res 1999; 93: 35-42
23. Teramoto S, Bartlett JS, McCarty D, Xiao X, Sumulski RJ, Boucher RC. Factors influencing adeno-associated virus-mediated gene transfer to human cystic fibrosis airway epithelial cells: a comparison with adenovirus vector. J Virol 1998; 72: 8904-12
24. Teramoto S, Suzuki T, Matsuse T, Ouchi Y. Effect of ambroxol on oxygen radical production and generation by bronchoalveolar lavage cells in young and aged guinea pigs. Jpn J Pharmacol 1998; 78: 429-34
25. Teramoto S, Fukuchi Y, Uejima Y, Teramoto K, Oka T, Orimo H. A novel model of senile lung: senescence-accelerated mouse (SAM). Am J Respir Crit Care Med 1994; 150: 238-44
26. Teramoto S, Fukuchi Y, Uejima Y, Teramoto K, Orimo H. Biochemical characteristics of lungs in senescence-accelerated mouse (SAM). Eur Respir J 1995; 8: 450-6
27. Teabeaut JR. Aspiration of gastric contents. An experimental study. Am J Pathol 1952; 28: 51-67
28. Greenfield LJ, Singleton RP, McCaffree DR, Coalson JJ. Pulmonary effects of experimental graded aspiration of hydrochloric acid. Ann Surg 1969; 170: 74-86
29. Hamelberg W, Bosomworth PP. Aspiration pneumonitis: experimental studies and clinical observations. Anesth Analg 1964; 43: 669-77
30. Davidson JT, Rubin S, Eyal Z, Polliack A. A comparison of the pulmonary response to the endotracheal instillation of 0.1N hydrochloric acid and Hartmann's solution in the rabbit Br J Anaesth 1974; 46: 127-32
31. Teramoto S. Latent adenovirus infection in follicular bronchiectasis. Am J Respir Crit Care Med 1997; 155: 2113-14
32. Grubb B, Pickles RJ, Ye H, et al. Inefficiency of in vivo gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 1994; 371: 802-26
33. Knowles MR, Hohnekker KW, Zhou Z, et al. A controlled study of transfer by adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med 1995; 333: 823-31