Solution and adsorption behaviour of lecithin surfactants in CFC suspensions: A light scattering study in aerosol propellants

International Journal of Pharmaceutics

Volumn 186, Issue 1, 1999, Pages 63-69

  Malik, Shagufta ^a   Washington, Clive ^a   Purewal, Tarlochan S ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b 3M Drug Delivery Systems   (United Kingdom)

Author keywords

Aerosol; Hemimicelle; Lecithin; Light scattering; Metered dose inhaler; Wormlike micelle

Indexed keywords

CYCLOHEXANE; EPIKURON 200; PHOSPHATIDYLCHOLINE; PROPELLANT; SALBUTAMOL SULFATE; SURFACTANT; UNCLASSIFIED DRUG;

AEROSOL; ARTICLE; LIGHT SCATTERING; MICELLE; PRIORITY JOURNAL; TEMPERATURE; TURBIDITY; VISCOSITY;

ADSORPTION; AEROSOLS; CHLOROFLUOROCARBONS; LIGHT; MICELLES; NEBULIZERS AND VAPORIZERS; PHOSPHATIDYLCHOLINES; SCATTERING, RADIATION; SOLUTIONS; SURFACE-ACTIVE AGENTS; SUSPENSIONS;

EID: 0032801089     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00138-6     Document Type: Article

References (12)

1. Brasher, L., Kaler, E.W., 1996. A small-angle neutron scattering (SANS) contrast variation investigation of aggregate composition in catanionic surfactant. Langmuir 12, 6270-6276.
2. Clint, J.H., 1992. Surfactant Aggregation. Chapman and Hall, New York.
3. Evans, R.M., Attwood, D., Chatham, S.M., Farr, S., 1990. The effect of solubilized water on the size and shape of lecithin micelles in an apolar solvent. J. Pharm. Pharmacol. 42, 601-605.
4. Malik, S., Washington, C., Purewal, T.S., 1999. Adsorption of surfactants to polar solids in nonaqeous suspensions - formation of inverse hemimicelles. Langmuir, submitted for publication.
5. Mortensen, K., Pedersen, J.S., 1993. Structural study on the micelle formation of poly(ethylene oxide)-poly(propylene oxide- poly(ethylene oxide) triblock copolymer in aqueous solution. Macromolecules 26, 805-812.
6. Scartazzini, R., Luisi, P.L., 1988. Organogels from lecithins. J. Phys. Chem. 92, 829-833.
7. Schillen, K., Brown, W., Johnsen, R.M., 1994. Micellar sphere to rod transition in an aqueous triblock copolymer system - a dynamic light scattering study of translational and rotational diffusion. Macromolecules 27, 4825-4832.
8. Schurtenberger, P., 1996. Structure and dynamics of viscoelastic surfactant solutions - an application of concepts from polymer science. Chimia 48, 72-78.
9. Schurtenberger, P., Scartazzini, R., Magid, L.J., Leser, M.E., Luisi, P.L., 1990. Structural and dynamic properties of polymer-like reverse micelles. J. Phys. Chem. 94, 3695-3701.
10. Sidhu, B.K., Washington, C., Davis, S.S., Purewal, T.S., 1993. Electrophoretic properties of lactose and salbutamol sulfate suspensions in halogenated solvents. Langmuir 9, 839-843.
11. Stewart, J.C., 1980. Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal. Biochem. 104, 10.
12. Washington, C., 1990. The stability of intravenous fat emulsions in parenteral nutrition mixtures. Int. J. Pharm. 66, 1-21.