IL-15/IL-15Rα intracellular trafficking in human cells and protection from apoptosis

Annals of the New York Academy of Sciences

Volumn 876, Issue , 1999, Pages 236-245

  Pereno, Raffaele ^a   Gaggero, Alessia ^b   Scudeletti, Marco ^c   Lanza, Lorella ^c   Meazza, Raffaella ^b,d   Mishal, Zohar ^e   Jasmin, Claude ^a   Indiveri, Francesco ^b   Ferrini, Silvano ^b   Azzarone, Bruno ^a,c  

^a HÔPITAL PAUL BROUSSE   (France)

^b CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d DOCS Faculty of Medicine   (France)

^e CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; SIGNAL PEPTIDE;

ANIMAL CELL; APOPTOSIS; CELL NUCLEUS; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN SECRETION; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

EID: 0032800811     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07644.x     Document Type: Conference Paper

References (18)

1. 1. GRABSTEIN, K. H. et al. 1994. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264: 965-968.
2. 2. BAMFORD, R. et al. 1996. IL-15 the role of translational regulation in their expression. J. Leukocyte Biol. 59: 476-480.
3. 3. ANDERSON, D. M. et al. 1995. Functional characterization the human IL-15Rα chain and close linkage of IL-15RA and IL-2RA genes. J. Biol. Chem. 270: 29862-29869.
4. 4. TAGAYA, Y. et al. 1996. IL-15: A pleiotropic cytokine with diverse receptor/signalling pathways whose expression is controlled at multiple levels. Immunity 4: 329-336.
5. 5. MEAZZA, R. et al. 1996. Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines. Oncogene 12: 2187-2192.
6. 6. BARZEGAR, C. et al. 1998. IL-15 is produced by a subset of human melanomas, and is involved in the regulation of markers of melanoma progression through juxtacrine loops. Oncogene 16: 2503-2512.
7. 7. BAMFORD, R. et al. 1996. IL-15/T production by the adult T cell leukemia cell line HuT-102 is associated with an HTLV-I-R/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. Proc. Natl. Acad. Sci. USA 93: 2897-2902.
8. 8. MEAZZA, R. et al. 1997. Expression of two inlerleukin-15 mRNA iso forms in human tumors does not correlate with secretion: Role of different signal peptides. Eur. J. Immunol. 27: 1049-1054.
9. 9. ONU, A. et al. 1997. Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J. Immunol. 158: 255-262.
10. 10. TAGAYA, Y. et al. 1997. Generation of secretable and non-secretable interleukin-15 isoforms through alternate usage of signal peptides. Proc. Natl. Acad. Sci. USA 94: 14444-14449.
11. 11. MCINNES, I. B. & F. Y. LIFW. 1998. Interleukin 15: A proinflammatory role in rheumatoid arthritis synovitis. Immunol. Today 19: 75-79.
12. 12. THURKOW, E. W. et al. 1997. Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with Yersinia-induced arthritis and ostcoarthritis. J. Pathol. 181: 444-450.
13. 13. GIRARD, D. et al. 1996. Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils: Modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15. Blood 88: 3176-3184.
14. 14. AL MUGHALES, J. et al. 1996. The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokines. Clin. Exp. Immunol. 106: 230-236.
15. 15. RUCHATZ, H. et al. 1998. Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: A role for IL-15 in development of antigen-induced immunopathology. J. Immunol. 160: 5654-5660.
16. 16. MANISHA, H. et al. 1998. A role for IL-15 in rheumatoid arthritis? Nat. Med. 4: 643.
17. 17. KRAUSE, H. et al. 1998. IL-15 and TNFα are functional antagonists in the control of apoptosis in murine L929 fibroblasts (abstract). Proc. Assoc. Assoc. Cancer Res. 39: 463.
18. 18. CARSON, W. E. et al. 1997. A potential role for interleukin-15 in the regulation of human natural killer cell survival. J. Clin. Invest. 99: 937-943.