Cyclosporin A reduces the inflammatory response to a multi-mutant herpes simplex virus type-1 leading to improved transgene expression in sympathetic preganglionic neurons in hamsters

Journal of NeuroVirology

Volumn 5, Issue 3, 1999, Pages 268-279

  Mabon, P J ^a   Weaver, L C ^a   Dekaban, G A ^a  

^a NONE

Author keywords

Cyclosporin A; Inflammation; Methylprednisolone; Recombinant herpes simplex virus type 1; Spinal cord; Transgene expression

Indexed keywords

AZATHIOPRINE; BETA GALACTOSIDASE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; EXPRESSION VECTOR; GENE EXPRESSION; GENE TRANSFER; GENETIC ENGINEERING; HAMSTER; HERPES SIMPLEX VIRUS 1; INFLAMMATION; INFLAMMATORY INFILTRATE; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PREGANGLIONIC NERVE CELL; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; SECONDARY IMMUNE RESPONSE; TRANSGENE;

EID: 0032800332     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550289909015813     Document Type: Article

References (59)

1. Abercrombie M (1946). Estimation of nuclear population from microtome sections. Anat Rec 94: 239-247.
2. Almawi WY, Beyhum HN, Rahme AA, Rieder MJ (1996). Regulation of cytokine and cytokine receptor expression by glucocorticoids. J Leukoc Biol 60: 563-572.
3. Andersen JK, Garber DA, Meaney CA, Breakefield XO (1992). Gene transfer into mammalian central nervous system using herpes virus vectors: Extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter. Hum Gene Ther 3: 487-499.
4. Benson A, Ziegler HK (1989). Macrophages as targets for inhibition by cyclosporine. Transplantation 47: 696-703
5. Berkowitz-Balshayi C, Rosen-Wolff A, Darai G, Becker Y (1995). Immunosuppression of Mice by cyclophosphamide (CyP) and cyclosporin A (CsA) changes the course of HSV-1 infection and the distribution of viral DNA in target organs. In Vivo 9: 155-162.
6. Bloom DC, Maidment NT, Tan A, Dissette VB, Feldman LT, Stevens J (1995). Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus. Mol Brain Res 31: 48-60.
7. Bolton C (1995). Recent advances in the pharmacological control of experimental allergic encephalomyelitis (EAE) and the implications for multiple sclerosis treatment. Mult Scler 1: 143-149.
8. Borlongan CV, Stahl CE, Cameron DF, Saporta S, Freeman TB, Cahill DW, Sanberg PR (1996). CNS immunological modulation of neural graft rejection and survival. Neurol Res 18: 297-304.
9. Branisteanu DD, Waer M, Sobis H, Marcelis S, Vandeputte M, Bouillon R (1995). Prevention of murine experimental allergic encephalomyelitis cooperative effects of cyclosporin and 1a,25-(OH)2D3. J Neuroimmunol 61: 151-160.
10. Brubaker JO, Thompson CM, Morrison LA, Knipe DM, Siber GR, Finberg RW (1996). Th1-Associated immune responses to β-galactosidase expressed by a replication-defective herpes simplex virus. J Immunol 157: 1598-1604.
11. Calder VL, Bellamy AS, Owen S, Lewis C, Rudge P, Davidson AN, Feldmann M (1987). Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients. Clin Exp Immunol 70: 570-577.
12. Chaudhary LR, Avioli LV (1996). Regulation of interleukin-8 gene expression by interleukin-1 beta, osteotropic hormones, and protein kinase inhibitors in normal human bone marrow stromal cells. J Biol Chem 271: 16591-16596.
13. Christ M, Lusky M, Stoeckel F, Dreyer D, Dieterle A, Michou AI, Pavirani A, Mehtali M (1997). Gene therapy with recombinant adenovirus vectors: evaluation of the host immune response. Immunol Lett 57: 19-25.
14. Daar AS (1995). Developments in immunosuppressive therapy. Transplant Proc 27: 2671-2675.
15. Davidson BL, Allen ED, Kozarsky KF, Wilson JM, Roessler BJ (1993). A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet 3: 219-223.
16. Davidson BL, Bohn MC (1997). Recombinant adenovirus: A gene transfer vector for study and treatment of CNS diseases. Exp Neurol 144: 125-130.
17. Durham HD, Alonso-Vanegas MA, Sadikot AF, Zhu L, Lochmuller H, Massie B, Nalbantoglu J, Karpati G (1997). The immunosuppressant FK506 prolongs transgene expression in brain following adenovirus-mediated gene transfer. NeuroReport 8: 2111-2115.
18. Fink DJ, DeLuca NA, Goins WF, Glorioso JC (1995). Gene transfer to neurons using herpes simplex virus-based vectors. Ann Rev Neurosci 19: 265-287.
19. Frishberg Y, Meyers CM, Kelly CJ (1996). Cyclosporine A regulates T cell-epithelial cell adhesion by altering LFA-1 and ICAM-1 expression. Kidney Int 50: 45-53.
20. Glorioso JC, Bender MA, Coins WF, Fink DJ, DeLuca N (1995a). HSV as a gene transfer vector for the nervous system. Molec Biotech 4: 87-98.
21. Glorioso JC, DeLuca NA, Fink DJ (1995b). Development and application of herpes simplex virus vectors for human gene therapy. Ann Rev Microbiol 49: 675-710.
22. Glorioso JC, Coins WF, Meaney CA, Fink DJ, DeLuca NA (1994). Gene transfer to brain using herpes simplex virus vectors. Ann Neurol 35: S28-S34.
23. Guerette B, Vilquin JT, Gingras M, Gravel C, Wood KJ, Tremblay JP (1995). Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4Ig. Human Gene Ther 7: 1455-1463.
24. Haberal M, Demirag A, Bilgin N, Arslan G, Buyukpamukcu N (1995). Immunosuppressive Protocols at Transplantation Centers in Turkey. Transplant Proc 27: 2776-2777.
25. Hermens WTJMC, Verhaagen J (1997). Adenoviral vector-mediated gene expression in the nervous system of immunocompetent wistar and T cell-deficient nude rats: preferential survival of transduced astroglial cells in nude rats. Human Gene Ther 8: 1049-1063.
26. Herz J, Gerard RD (1993). Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 90: 2812-2816.
27. Hong S, Neve R, Howe J, Kalb RG (1995). Gene transfer into spinal cord using HSV vectors. Neurosci Abs 21: 536 (Abstract).
28. Huard J, Akkaraju G, Watkins SC, Pike-Cavalcoli M, Glorioso JC (1997). LacZ gene transfer to skeletal muscle using a replication defective herpes simplex virus type 1 mutant vector. Human Gene Ther 8: 439-452.
29. Huitinga I, Ruuls SR, Jung S, Vanrooijen N, Hartung H-P, Dijkstra CD (1995). Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats. Clin Exp Immunol 100: 344-351.
30. Johnson PA, Wang MJ, Friedman T (1994). Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J Virol 68: 6347-6362.
31. Juillard V, Villefrox P, Godfrin D, Pavirani A, Venet A, Guillet JG (1995). Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector. Eur J Immunol 25: 3467-3473.
32. Kaplan JM, Smith AE (1997). Transient immunosuppression with deoxyspergualin improves longevity of transgene expression and ability to readminister adenoviral vector to the mouse lung. Human Gene Ther 8: 1095-1104.
33. Kasaian MT, Biron CA (1990). Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus. J Immunol 144: 299-306.
34. Keir SD, Mitchell WJ, Feldman LT, Martin JR (1995). Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-2 vector. J Neurovirol 1: 259-267.
35. Kennedy PGE, Steiner I (1993). The use of herpes simplex virus vectors for gene therapy in neurological disease. Quart J Medicine 86: 697-702.
36. Lemstrom KB, Raisannen-Sokolowski AK, Hayry PJ, Koskinen PK (1996). Triple Drug Immunosuppression Significantly Reduces Aortic Allograft Arteriosclerosis in the Rat. Arteriosclerosis, Thrombosis, and Vascular Biology 16: 553-564.
37. LeVatte MA, Cassam AK, Dekaban GA, Weaver LC (1998). Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic preganglionic neurons and a comparison to adenovirus vectors. Neurosci 86: 1321-1336.
38. LeVatte MA, Dekaban GA, Weaver LC (1997a). Gene transfer into sympathetic preganglionic neurons in vivo using a nonreplicating thymidine kinase deficient herpes simplex virus type 1. Neurosci 80: 893 - 906.
39. LeVatte MA, Mabon PJ, Weaver LC, Dekaban GA (1997b). Simultaneous identification of two populations of sympathetic preganglionic neurons using recombinant herpes simplex type 1 virus expressing different reporter genes. Neurosci 82: 1253-1267.
40. Liu T, Tang Q, Hendricks RL (1996). Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. J Virol 70: 264-271.
41. Mabon PJ, LeVatte MA, Dekaban GA, Weaver LC (1997). Identification of sympathetic preganglionic neurons controlling the small intestine in hamsters using a recombinant herpes simplex virus type-1. Brain Res 753: 245-250.
42. Martin D, Near SL, Bendele A, Russell DA (1995). Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of Lewis rats with myelin basic protein. Exp Neurol 131: 222-228.
43. Murase N, Demetris AJ, Tanabe M, Miyazawa H, Valdivia LA, Nakamura K, Starzl TE (1993). Effect of FK506 and antiproliferative agents for heart and liver xenotransplantation from hamster to rat. Transplant Proc 25: 425-426.
44. Mustafa M, Diener P, Sun J-B, Link H, Olsson T (1993). Immimopharmacologic modulation of experimental allergie encephalomyelitis: low-dose cyclosporin A treatment causes disease relapse and increased systemic T and B cell-mediated myelin-directed autoimmunity. Scand J Immunol 38: 499-507.
45. Palay DA, Cluff CW, Wentworth PA, Ziegler HK (1986). Cyclosporine inhibits macrophage-mediated antigen presentation. J Immunol 136: 4348-4353.
46. Pedersen EB, Poulsen FR, Zimmer J (1995). Prevention of mouse-rat brain xenograft rejection by a combination of cyclosporin A, prednisolone and azathioprine. Exp Brain Res 106: 181-186.
47. Pedersen EB, Zimmer J, Finsen B (1997). Triple immunosuppression protects murine intracerebral, hippocampal xenografts in adult rat hosts: effects on cellular infiltration, major histocompatability complex antigen induction and blood-brain barrier leakage. Neurosci 78: 685-701.
48. Peltekian E, Parrish E, Bouchard C, Peschanski M, Lisovoski F (1997). Adenovirus-mediated gene transfer to the brain: methodological assessment. J Afeurosci Meth 71: 77-84.
49. Perico N, Remuzzi G (1997). Prevention of transplant rejection; current treatment guidelines and future developments. Drugs 54: 533-570.
50. Pyner S, Coote JH (1994). A comparison between the adult rat and neonate rat of the architecture of sympathetic preganglionic neurones projecting to the superior cervical ganglion, stellate ganglion and adrenal medulla. J Auton Nerv Syst 48: 153-166.
51. Schramm LP, Adair JR, Stribling JM, Gray LP (1975). Preganglionic innervation of the adrenal gland of the rat: a study using horseradish peroxidase. Exp Neurol 49: 540-553.
52. Shin GT, Khanna A, Ding R, Sharma VK, Lagman M, Li B, Suthanthiran M (1998). In vivo expression of transforming growth factor-beta in humans - Stimulation by cyclosporine. Transplantation 65: 313-318.
53. Sokol RR, Rohlf FJ (1981). Biometry. In: The Principles and Practice of Statistics in Biological Research. WH Freeman and Co., San Francisco, pp 175-204.
54. Tripathy SK, Black HB, Goldwasser E, Leiden JM (1996). Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat Med 2: 545-550.
55. Wolfe JH, Deshmane SL, Fraser NW (1996). Herpes virus vector gene transfer and expression of B-glucuronidase in the central nervous system of MPS VII mice. Nat Genet 1: 379-384.
56. Wood MJA, Byrnes AP, Pfaff DW, Rabkin SD, Charlton HM (1994). Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors. Gene Therapy 1: 283-291.
57. Wu L, Morahan PS, Leary K (1993). Regulation of herpes simplex virus type 1 gene expression in nonpermissive murine resident peritoneal macrophages. J Leukoc Buil 53: 61-65.
58. Yang Y, Nunes FA, Berenesi K, Furth EE, Gonczol E, Wilson JM (1994). Cellular immunity to viral antigens limits El-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 91: 4407-4411.
59. Zamvil SS, Steinman L (1990). The T lymphocyte in experimental allergic encephalomyelitis. Ann Rev Immunol 8: 579-621.