Protection from 1-cyano-3,4-epithiobutane nephrotoxicity by aminooxyacetic acid and effect on xenobiotic-metabolizing enzymes in male Fischer 344 rats

Journal of Applied Toxicology

Volumn 19, Issue 4, 1999, Pages 237-249

  VanSteenhouse, Jan L ^a   Prescott, Judith S ^a,b   Swenson, David H ^a,c  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Saginaw State Universty   (United States)

Author keywords

glutamylcysteine synthetase; 1 cyano 3,4 epithiobutane; Acivicin; Aminooxyacetic acid; Bioactivation; ECOD; EH; EROD; Glutathione; Glutathione S transferase; Nephrotoxicity; Nitrile; Probenecid; PROD

Indexed keywords

4,5 EPITHIOVALERONITRILE; ACIVICIN; AMINOOXYACETIC ACID; CYANIDE; CYSTEINE SYNTHASE; CYTOCHROME P450; EPOXIDE HYDROLASE; ETHOXYRESORUFIN DEETHYLASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PENTOXYRESORUFIN DEALKYLASE; PROBENECID; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIVER; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

7-ALKOXYCOUMARIN O-DEALKYLASE; AMINOOXYACETIC ACID; ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ENZYME INHIBITORS; EPOXIDE HYDROLASES; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; ISOXAZOLES; KIDNEY; KIDNEY DISEASES; MALE; MICROSOMES, LIVER; NITRILES; PROBENECID; RATS; RATS, INBRED F344;

EID: 0032800003     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199907/08)19:4<237::AID-JAT569>3.0.CO;2-7     Document Type: Article

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