Cytotoxicity against human leukemic cell lines, and the activity on the expression of resistance genes of flavonoids from Platanus orientalis

Anticancer Research

Volumn 19, Issue 3 A, 1999, Pages 2085-2088

  Mitrocotsa, D ^a   Bosch, S ^b   Mitaku, S ^a   Dimas, C ^c   Skaltsounis, A L ^a   Harvala, C ^a   Briand, G ^b   Roussakis, Christos ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITÉ DE NANTES   (France)

^c Hellenic Anticancer Institute   (Greece)

Author keywords

Cytotoxicity; DNA synthesis; Flavonoids; GST ; Leukemic cell line; MDR 1

Indexed keywords

FLAVONOID; KAEMPFEROL;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BURKITT LYMPHOMA; DNA REPLICATION; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONOIDS; GENE EXPRESSION REGULATION, LEUKEMIC; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HL-60 CELLS; HUMANS; ISOENZYMES; K562 CELLS; LEUKEMIA; LEUKEMIA, T-CELL, ACUTE; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PLANTS, MEDICINAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED;

EID: 0032799880     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Pathak D, Pathak K, Singla AK: Flavonoids as medicinal agents -Recent advances. Fitoterapia 62: 371-389, 1991.
2. Mori A, Nishino C, Enoki N, Tawata S: Antibacterial activity and mode of action of plant flavonoids against Proteus vulgaris and Staphyloccus aureus. Phytochemistry 26: 2231-2234, 1987.
3. Jbeda A, Esteve ML, Alkaraz MJ, Cheeseman KH, Slater TF: Effect of flavonoids on cytochrome P-450 from rat liver microsomes: Inhibition of enzyme activities and protection against peroxidative damage. Phytotherapy Res 9: 416-420, 1995.
4. Van Hoof L, Vanden Berghe D, Hatfield G, Vlietinck A: Plant antivireal agents; 3-methoxyflavones as potent inhibitors of viral-induced block of cell synthesis. Planta Medica 50: 513-517, 1984.
5. Yoshida M, Yamamoto M, Nikaido T: Quercetin arrests Human leucemic T-cells in late G1 phase ofthe cell cycle. Cancer Res 52: 6676-6681, 1992.
6. Traganos F, Ardelt B, Halko N, Bruno S, Darzynkiewicz Z: Effect of Genistein on the growth and cell cycle progression of normal human lymphocytes and human leucemic MOLT-4 and HL-60 cells. Cancer Res 52: 6200-6208, 1992.
7. Uddin S, Choudhry MA: Inhibition of DNA synthesis by flavonoid quercetin. Polyphenols Communications 96, Bordeaux, France, July 15-18, 1996.
8. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y: Genistein, a specific inhibitor of Tyrosine-specific Protein Kinases. J Biol Chem 262: 5592-5595, 1987.
9. Konstantinou A, Mehta R, Runyan C, Rao K, Vaughan A, Moon R: Flavonoids as DNA topoisomerase antagonists and poisons: a structure-activity relationships. J Nat Pr 59: 701-703, 1996.
10. Zahir A, Jossang A, Bodo B: DNA topoisomerase I inhibitors: cytotoxic flavones from Lethedon tannaensis. J Nat Prod 58: 217-225, 1995.
11. Beutler J, Cardellina J, Lin C, Hamel E, Cragg G, Boyd M: Centauredin, a cytotoxic flavone from Polymnia fiutlcosa, inhibits tubulin polymerization. Bioorganic and Medicinal Chemistry Letters 3: 581-584, 1993.
12. Prochaska H, Scotto K: Use of flavonoids to treat multidrug resistance cancer cells. United States Patent No 5,336,685, 1993.
13. Boschi S, Siavoshian S, Jacquot C, Tomasoni C, Dabouis G, Elanbaloussi Y, Leneel T, More MT, Roussakis C: Correlation between multidrug resistance and the degree of differentiation of Non-Small-Cell Bronchopulmonary Carcinoma (NSCLC) in vitro and in vivo. Anticancer Res 17: 4595-4598, 1997.
14. Jakoby B, Habig H: In Enzymatic Basis of Detoxification; B. Jakoby, Ed; Academic Press: New York, 1980; pp 63-64.
15. Morrow C, Cowan K: Glutathion S-Transferases and drug resistance. Cancer Cells 2: 15-22, 1990.
16. Mitrocotsa D, Mitaku S, Demetzos C, Harvala C, Mentis A, Perez S, Kokkinopoulos D: Bioactive compounds from the buds of Platanus orientalis and isolation of a new kaempferol glycoside. Planta Medica 59: 517-520, 1993.
17. Denizot F, Lang R: Rapid colorimetric assay for cell growth and survival. J Immunol Methods 89: 271-277, 1986.
18. Dimas C, Demetzos C, Marcellos M, Sotiriadou R, Malamas M, Kokkinopoulos D: Cytotoxic activity of labdane type diterpenes against human leucemic cell lines in vitro. Planta Medica 64: 208-211, 1998.
19. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chlorophorm extraction. Anal Biochem 162: 156-159, 1987.