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Naturally occurring chemical carcinogens that may be present in foods
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Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole and some known or possible metabolites
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Wislocki, P.G., Miller, E.C., Miller, J.A., McCoy, E.C. and Rosenkranz, H.S. (1977) Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole and some known or possible metabolites. Cancer Res., 37, 1883-1891.
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Strong evidence from the studies with brachymorphic mice and pentachlorophenol that 1'-sulfooxysafrole is the major electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver
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Boberg, E.W., Miller, E.C., Miller, J.A., Poland, A. and Liem, A. (1983) Strong evidence from the studies with brachymorphic mice and pentachlorophenol that 1'-sulfooxysafrole is the major electrophilic and carcinogenic metabolite of 1'-hydroxysafrole in mouse liver. Cancer Res., 43, 5163-5173.
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