A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function

British Journal of Clinical Pharmacology

Volumn 48, Issue 2, 1999, Pages 200-206

  Hindmarch, I ^a   Shamsi, Z ^a   Stanley, N ^a   Fairweather, D B ^a  

^a HPRU Medical Research Centre   (United Kingdom)

Author keywords

Antihistamines; Cognitive function; Fexofenadine; Loratadine; Promethazine; Psychomotor performance

Indexed keywords

ANTIHISTAMINIC AGENT; FEXOFENADINE; LORATADINE; PROMETHAZINE;

ACTIMETRY; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL FLICKER FUSION; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PSYCHOMOTOR DISORDER; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; RECOGNITION; RESPONSE TIME; SEDATION;

ADULT; COGNITION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; FLICKER FUSION; HISTAMINE H1 ANTAGONISTS; HUMANS; HYPNOTICS AND SEDATIVES; LORATADINE; MALE; MIDDLE AGED; PROMETHAZINE; PSYCHOMOTOR PERFORMANCE; REACTION TIME; TERFENADINE; WRIST;

EID: 0032799404     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00993.x     Document Type: Article

References (29)

1. 1 Janssens MM, Howarth PH. The antihistamines of the nineties. Clin Rev Allergy 1993; 11: 111-153.
2. 2 Simons FER. The therapeutic index of newer H1-receptor antagonists. Clin Exp Allergy 1994; 24: 707-723.
3. 3 Mattila MJ, Matilla M, Konno K. Acute and sub acute actions on human performance and interactions with diazepam of temelastine and diphenhydramine. Eur J Clin Pharmacol 1986; 31: 291-298.
4. 4 Goetz DW, Jacobson MM, Apaliski SJ, Repperger DW, Martin ME. Objective antihistamine side effects are mitigated by evening dosing of hydroxyzine. Ann Allergy 1991; 67: 448-454.
5. 5 Brookhuis KA, de Vries G, de Waard D. Acute and subchronic effects of histamine (H1) receptor antagonist ebastine in 10, 20 and 30mg dose, and triprolidine 10mg on car driving performance. Br J Clin Pharmacol 1993; 36: 67-70.
6. 6 Seppala T, Savolainen K. Effects of astemizole on human psychomotor performance. Curr Ther Res 1982; 31: 638-344.
7. 7 Rombaut NE, Bhatti JZ, Alford C, Curran S, Hindmarch I. Psychopharmacological aspects of antihistamines. Pharmacopsychoecologica 1989; 2: 21-30.
8. 1 antihistamines. Ann Allergy 1991; 67: 625-633.
9. 1 receptor antagonists. Allergy 1995; 50: 7-11.
10. 10 Simons FER, Simons K. Peripheral H1 blockade effect of fexofenadine. Ann Allergy, Asthma Immunol 1997; 79: 530-532.
11. 11 Bernstein DI, Schoenwetter WF, Nathan RA, Storms W, Ahlbrandt R, Mason J. Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis. Ann Allergy, Asthma Immunol 1997; 79: 443-532.
12. 12 Parkin C, Kerr JS, Hindmarch I. The effects of practice on choice reaction time and critical flicker fusion threshold. Human Psychopharmacol 1997; 12: 65-70.
13. 13 Hindmarch I. A 1, 4 benzodiazepine, temazepam, its effect on some psychological limit of sleep and behaviour. Arzneimittel Forschung (Drug Res) 1975; 11: 1836-1839.
14. 14 Hindmarch I, Parrot AC. The effect of sub-chronic administration of three dose levels of 1,4-benzodiazepine derivative, clobazam, on subjective assessment of sleep and aspects of psychomotor performance the morning following night time medication. Arzneimittel Forsch (Drug Res) 1978; 28: 2169-2172.
15. 15 Hindmarch I, Subhan Z, Stoker MJ. The effects of zimeldine and amitriptyline on car driving and psychomotor performance. Acta Psychiat Scand 1983; 68: 141-146.
16. 16 Woodworth RS, Schlosberg H. Experimental Psychology, Methuen, London, 1958.
17. 17 Hindmarch I, Gudgeon AC. The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability. Br J Clin Pharmacol 1980; 10: 145-150.
18. 18 Stanley N. Actigraphy in psychopharmacology. In Human Psychopharmacology, Methods and Measures, Vol 6 eds Hindmarch I, Stonier PD. John Wiley & Sons, Chichester., 1997; 67-93.
19. 19 Stanley N, Hindmarch I. Actigraphy can measure antidepressant induced daytime sedation in healthy volunteers. Human Psychopharmacol 1997; 12: 437-443.
20. 20 Mullaney DJ, Kripke DF, Messin S. Wrist-actigraphic estimation of sleep time. Sleep 1980; 3: 83-92.
21. 21 Cole RJ, Kripke DF. Progress in automatic scoring by wrist actigraph. Sleep Res 1988; 19: 331.
22. 22 Sadeh A, Alster J, Urbach D, Lavie P. Actigraphically based automatic bedtime sleep-wake scoring: validity and clinical applications. J Ambulatory Monitoring 1989; 2: 209-216.
23. 23 Sadeh A, Sharkey KM, Carskadon MA. Activity-based sleep-wake identification. An empirical test of methodological issues. Sleep 1994; 17: 201-207.
24. 24 Cole RJ, Kripke DF, Greun W, Mullaney DJ, Gillin JC. Automatic sleep/wake identification from wrist actigraphy. Sleep 1992; 15: 461-469.
25. 25 Mann KV, Crowe JP, Tietze K. Non sedating histamine receptor antagonists. Clin Pharm 1989; 8: 331-344.
26. 26 Belaich S, Bruttmann G, DeGreef H, et al. Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria. Annals Allergy 1990; 64: 191-194.
27. 27 Vermeeren A, O'Hanlon JF. Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance. J Allergy Clin Immunol 1997; 101: 306-311.
28. 28 Kerr JS, Dunmore C, Hindmarch I. The psychomotor and cognitive effects of a new antihistamine, mizolastine, compared to terfenadine, triprolidine and placebo in healthy volunteers. Eur J Clin Pharmacol 1994; 47: 331-335.
29. 29 Hindmarch I. It's all in the mind: Measuring somnolence and CNS drug side effects. Human Psychopharmacol, Clin Exp 1988; 13: 385-387.