Pharmacological actions of monovalent ionophores on spontaneously beating rabbit sino-atrial nodal cells

General Pharmacology

Volumn 33, Issue 2, 1999, Pages 151-159

  Satoh, Hiroyasu ^a   Tsuchida, Katsuharu ^a  

^a Department of Pharmacology   (Japan)

Author keywords

Cellular Ca2+ concentration; Ionic currents; Lonomycin A; Monensin; Nigericin; Sino atrial node; Spontaneous activity

Indexed keywords

IONOPHORE; LONOMYCIN A; MONENSIN; NIGERICIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CHRONOTROPISM; CONTROLLED STUDY; DOSE RESPONSE; IN VITRO STUDY; MICROELECTRODE; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT; SINUS NODE; SINUS NODE DYSFUNCTION;

ACTION POTENTIALS; ANIMALS; CALCIUM; IONOPHORES; MONENSIN; NIGERICIN; RABBITS; SINOATRIAL NODE; TIME FACTORS;

EID: 0032799156     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(98)00271-7     Document Type: Article

References (35)

1. Armstrong C.M., Matteson D.R. Two distinct populations of calcium channels in a clonal line of pituitary cells. Science. 227:1985;65-67.
2. Bean B.P. Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selective, and pharmacology. J Gen Physiol. 86:1985;1-30.
3. Berridge M.J. Inositol triphosphate and calcium signalling. Nature. 361:1993;315-325.
4. Carbone E., Swandulla D. Neuronal calcium channels. kinetics, blockade and modulation Prog Biophys Mol Biol. 54:1989;31-58.
5. Cooper D.M.F., Mons N., Karpen J.W. Adenylyl cyclases and the interaction between calcium and cAMP signalling. Nature. 374:1985;421-424.
6. Ca channels. Prog Biophys Mol Biol. 44:1984;215-267.
7. Fahim M., Pressmann B.C. Improvement of cardiac performance by carbocylic ionophore monensin in greyhound and mongrel dogs. Naunyn-Schmiedeberg's Arch Pharmacol. 333:1986;412-420.
8. Foreman J.C., Mongar J.L., Gomperts B.D. Calcium ionophores and movement of calcium ions following the physiological stimulus to a secretory process. Nature. 245:1973;249-251.
9. Gaide M.S., Lehr J.T., Wong S.S., Lattanzio F.A., Bassett A.L. Comparative study of the effects of salinomycin and monensin on electrophysiologic and contractile properties of canine myocardium. Eur J Pharmacol. 100:1984;321-327.
10. 2+ indicators with greatly improved fluorescence properties. J Biol Chem. 260:1985;3440-3450.
11. Hagiwara N., Irisawa H., Kameyama M. Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol (Lond). 395:1988;233-253.
12. Johnson R.G., Scarpa A. Catecholamine equilibration gradients of isolated chromaffin vesicles induced by the ionophore X-537A. FEBS Lett. 47:1974;117-121.
13. Levy J.V., Cohen J.A., Inesi G. Contractile effects of a calcium ionophore. Nature. 242:1973;461-463.
14. Mitani M., Otake N. Studies on the ionophorous antibiotics. XV J Antibiol Tokyo. 31:1978;750-755.
15. Noble D. The surprising heart. a review of recent progress in cardiac electrophysiology J Physiol (Lond). 353:1984;1-50.
16. Pressman B.C. Biological applications of ionophores. Ann Rev Biochem. 45:1976;501-530.
17. Pressman B.C., deGuzman N.T. Biological applications of ionophores. theory and practice Ann NY Acad Sci. 264:1975;373-386.
18. Satoh H. Positive and negative chronotropic effects of caffeine in spontaneously beating rabbit sino-atrial nodal cells. Gen Pharmacol. 24:1993;1223-1230.
19. 2+ concentration by protein kinase C stimulation in isolated single rabbit sino-atrial node cells. Gen Pharmacol. 25:1994;325-332. a.
20. 2+ channel inhibitors in the pacemaker depolarization in rabbit sino-atrial nodal cells. Gen Pharmacol. 26:1994;581-587. b.
21. Satoh H. Depression of the spontaneous activity by phorbol esters in young embryonic chick cardiomyocytes. Jpn J Pharmacol. 67:1995;297-304.
22. Satoh H., Seyama I. On the mechanism by which changes in extracellular pH affect the electrical activity of the sino-atrial node. J Physiol (Lond). 381:1986;181-191.
23. Satoh H., Sperelakis N. Hyperpolarization-activated inward current in embryonic chick cardiac myocytes. development change and modulation by isoproterenol and carbachol Eur J Pharmacol. 240:1993;283-290.
24. Satoh H., Uchida T. Morphological and electrophysiological changes induced by calcium ionophores (A23187 and X-537A) in spontaneously beating rabbit sino-atrial node cells. Gen Pharmacol. 24:1993;49-57.
25. Satoh H., Vassalle M. Role of calcium in caffeine-norepinephrine interactions in cardiac Purkinje fibers. Am J Physiol. 257:1989;H226-H237.
26. 2+-dependence of caffeine modulation of the rate-force relation in canine Purkinje fibers. J Pharmacol Exp Ther. 278:1996;826-835.
27. Satoh H., Tsuchida K., Hashimoto K. Electrophysiological actions of A23187 and X-537A in spontaneously beating and in voltage-clamped rabbit sino-atrial node preparations. Naunyn-Schmiedeberg's Arch Pharmacol. 339:1989;320-326.
28. Satoh H., Tsuchida K., Kaneko K., Otomo S. Comparative mechanical and electrical actions of A23187 and X-537a in canine Purkinje fibers. Gen Pharmacol. 23:1992;1103-1109.
29. Schwartz A., Lewis R.M., Hanley H.G., Munson R.G., Dial F.D., Ray M.V. Hemodynamic and biochemical effects of a new positive inotropic agents. antibiotic ionophores Ro 2-2985 Circ Res. 36:1974;102-111.
30. Smith J.E., Howell S.L. Effects of monensin on metabolism of isolated rat islets of Langerhans. Biochem J. 223:1984;423-432.
31. Strauss H.W., Harrison K., Langan J.K., Lebowitz E., Pitt B. Thallium-201 for myocardial imaging. Relation of thallium-201 to regional myocardial perfusion. Circulation. 51:1975;641-645.
32. Sutko J.L., Besch H.R., Bailey J., Zimmerman G., Watanabe A.M. Direct effects of the monovalent cation ionophores monensin and nigericin on myocardium. J Pharmacol Exp Ther. 203:1977;685-700.
33. Thoa N.B., Costa J.L., Moss J., Kopin I.J. Mechanism of release of norepinephrine from peripheral adrenergic neurons by the calcium ionophores X-537A and A23187. Life Sci. 14:1974;1705-1719.
34. Tsuchida K., Aihara H. Effects of a K ionophore, lonomycin A, on the action potential in canine cardiac Purkinje fibers. Jpn J Pharmacol. 41:1986;353-361.
35. Tsuchida K., Otomo S. Electrophysiological effects of monensin, a sodium ionophore, on cardiac Purkinje fibers. Eur J Pharmacol. 190:1990;313-320.