LNA (Locked Nucleic Acid)

Nucleosides and Nucleotides

Volumn 18, Issue 6-7, 1999, Pages 1365-1370

  Wengel, Jesper ^a   Koshkin, Alexei ^a,b   Singh, Sanjay K ^a   Nielsen, Poul ^c   Meldgaard, Michael ^a   Rajwanshi, Vivek K ^a   Kumar, Ravindra ^a   Skouv, Jan ^d   Nielsen, Christina B ^c   Jacobsen, Jens Peter ^c   Jacobsen, Nana ^b   Olsen, Carl E ^e  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Exiqon AS   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; COMPLEMENTARY RNA; DOUBLE STRANDED DNA; LIPOFECTIN; NUCLEIC ACID;

CIRCULAR DICHROISM; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; NUCLEAR MAGNETIC RESONANCE; NUCLEIC ACID HYBRIDIZATION; NUCLEIC ACID STRUCTURE; RNA BINDING; THERMODYNAMICS;

EID: 0032799151     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319908044718     Document Type: Conference Paper

References (16)

1. Herdewijn, P. Liebigs Ann. 1996, 1337 and references cited therein.
2. Cool, E. T. Chem. Rev. 1997, 97, 1473 and references cited therein.
3. LNA is defined as an ON containing one or more 2′-O,4′-C-methylene bicyclic ribonucleoside LNA monomers.
4. Singh, S. K.; Nielsen, P.; Koshkin, A. A.; Wengel, J. Chem. Commun. 1998, 455.
5. Koshkin, A. A.; Singh, S. K.; Nielsen, P.; Rajwanshi, V. K.; Kumar, R.; Meldgaard, M.; Olsen, C. E.; Wengel, J. Tetrahedron 1998, 54, 3607.
6. Koshkin, A. A.; Rajwanshi, V. K.; Wengel, J. Tetrahedron Lett. 1998, 39, 4381.
7. Singh, S. K.; Wengel, J. Chem. Commun. 1998, 1247.
8. Uracil and cytosine derivatives: (a) Obika, S.; Nanbu, D.; Hari, Y.; Morio, K.; In, Y.; Ishida, T.; Imanishi, T. Tetrahedron Lett. 1997, 38, 8735; (b) Obika, S.; Nanbu, D.; Hari, Y.; Andoh, J.; Morio, K.; Doi, T.; Imanishi, T. Tetrahedron Lett. 1998, 39, 5401.
9. Uracil and cytosine derivatives: (a) Obika, S.; Nanbu, D.; Hari, Y.; Morio, K.; In, Y.; Ishida, T.; Imanishi, T. Tetrahedron Lett. 1997, 38, 8735; (b) Obika, S.; Nanbu, D.; Hari, Y.; Andoh, J.; Morio, K.; Doi, T.; Imanishi, T. Tetrahedron Lett. 1998, 39, 5401.
10. Kumar, R.; Singh, S. K.; Koshkin, A. A.; Rajwanshi, V. K.; Meldgaard, M.; Wengel, J. Bioorg. Med. Chem. Lett. 1998, 8, 2219.
11. Singh, S. K.; Kumar, R.; Wengel, J. J. Org. Chem.. In press.
12. Deoxy-LNA is defined as an LNA consisting of LNA monomers and 2′-deoxynucleotide monomers. Ribo-LNA is defined as an LNA consisting of LNA monomers and ribonucleotide monomers. Homo-LNA is defined as an all-modified LNA.
13. Singh, S. K.; Kumar, R.; Wengel, J. J. Org. Chem. 1998, 63, 6078.
14. m value of more than 100°C towards poly(rA). However, it has been shown that this association involves a triple helical complex. (a) Brown, K. A.; Dempcy, R. O.; Bruice, T. C. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 6097; (b) Linkletter, B. A.; Bruice, T. C. Bioorg. Med. Chem. Lett. 1998, 8, 1285.
15. m value of more than 100°C towards poly(rA). However, it has been shown that this association involves a triple helical complex. (a) Brown, K. A.; Dempcy, R. O.; Bruice, T. C. Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 6097; (b) Linkletter, B. A.; Bruice, T. C. Bioorg. Med. Chem. Lett. 1998, 8, 1285.
16. Manuscript in preparation.