Use of phenylacetyl disulfide (PADS) in the synthesis of oligodeoxyribonucleotide phosphorothioates

Nucleosides and Nucleotides

Volumn 18, Issue 6-7, 1999, Pages 1195-1197

  Cheruvallath, Zacharia S ^a   Wheeler, Patrick D ^a   Cole, Douglas L ^a   Ravikumar, Vasulinga T ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; OLIGODEOXYRIBONUCLEOTIDE PHOSPHOROTHIOATE; PHENYLACETYL DISULFIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; COST EFFECTIVENESS ANALYSIS; DRUG MANUFACTURE; DRUG STORAGE; DRUG SYNTHESIS; GEL ELECTROPHORESIS; NUCLEOTIDE SEQUENCE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REACTION TIME; SOLID PHASE EXTRACTION;

EID: 0032799141     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319908044660     Document Type: Conference Paper

References (4)

1. Kamer, P. C. J.; Roelen, H. C. P. F.; van den Elst, H.; van der Marel, G. A.; van Boom, J. H. Tetrahedron Lett. 1989, 30, 6757.
2. Roelen, H. C. P. F.; Kamer, P. C. J.; van den Elst, H.; van der Marel, G. A.; van Boom, J. H. Recl. Trav. Chim. Pays-Bas., 1991, 110, 325.
3. The solution turns dark on storage at room temperature for extended period of time.
4. PADS is now commercially available from different vendors.