Iontophoretic transdermal delivery of salicylic acid dissolved in ethanol-water mixture in rats

Skin Pharmacology and Applied Skin Physiology

Volumn 12, Issue 4, 1999, Pages 221-226

  Murakami, Teruo ^a   Ihara, Chie ^a   Kiyonaka, Gakuji ^a   Yumoto, Ryoko ^a   Shigeki, Sadayuki ^a   Ikuta, Yushikazu ^a   Yata, Noboru ^a,b  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

Author keywords

Current density; Ethanol; Iontophoresis; pH; Salicylic acid

Indexed keywords

ALCOHOL; SALICYLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG SOLUBILITY; IONTOPHORESIS; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ETHANOL; HYDROGEN-ION CONCENTRATION; IONTOPHORESIS; MALE; PHARMACEUTICAL SOLUTIONS; RATS; RATS, WISTAR; SALICYLIC ACID; SOLVENTS; WATER;

EID: 0032797081     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000066246     Document Type: Article

References (14)

1. Banga AJ, Chien YW: Intophoretic delivery of drugs: Fundamental development and biomedical applications. J Controlled Release 1988;7: 1-24.
2. Chien YW, Banga AJ: Iontophoretic (transdermal) delivery of drugs: Overview of historical development. J Pharm Sci 1989;78:353-354.
3. Siddiqui O, Robert MS, Polack AE: Iontophoretic transport of weak electrolytes through the excised human stratum corneum. J Pharm Pharmacol 1989;41:430-432.
4. Yoshida NH, Robert MS: Prediction of cathodal iontophoretic transport of various anions across excised skin from different vehicles using conductivity measurements. J Pharm Pharmacol 1995;47:883-890.
5. Wearley L, Liu LC, Chien YW: Iontophoresis-facilitated transdermal delivery of verapamil. II. Factors affecting the reversibility of skin permeability. J Controlled Release 1989;9:231-242.
6. Srinivasan V, Higuchi WI, Sims SM, Ghanem AH, Behl CR: Transdermal iontophoretic drug delivery: Mechanistic analysis and application to polypeptide delivery. J Pharm Sci 1989;78:370-375.
7. Srinivasan V, Su MH, Higuchi WI, Behl CR: Iontophoresis of polypeptides: Effect of ethanol pretreatment of human skin. J Pharm Sci 1990; 79:588-591.
8. Bhatia KS, Gao S, Freeman TP, Singh J: Effect of penetration enhancers and iontophoresis on the ultrastructure and cholecystokinin-8 permeability through porcine skin. J Pharm Sci 1997;86:1011-1015.
9. Shigeki S, Murakami T, Yata N, Ikuta Y: Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast. Scand J Plast Reconstr Surg Hand Surg 1997;31:151-158.
10. Shigeki S, Murakami T, Kiyonaka G, Yata N, Ikuta Y: Transdermal iontophoretic delivery of triamcinolone acetonide: A preliminary study in hairless rats. Scand J Plast Reconstr Surg Hand Surg 1996;30: 177-181.
11. Murakami T, Yoshioka M, Okamoto I, Yumoto R, Higashi Y, Okahara K, Yata N: Effect of ointment bases on topical and transdermal delivery of salicylic acid in rats: Evaluation by skin microdialysis. J Pharm Pharmacol 1998;50:55-61.
12. Ohman H, Vahlquist A: In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis. Acta Derm Venereol (Stockh) 1994;74:375-379.
13. Tyle P: Ionophoretic devices for drug delivery. Pharm Res 1986;3: 318-326.
14. Oh SY, Keung LL, Bommannan D, Guy RH, Potts RO: Effect of current, ionic strength and temperature on the electrical properties of skin. J Controlled Release 1989;27:827-837.