Renal metabolism of acrylonitrile to cyanide: In vitro studies

Pharmacological Research

Volumn 40, Issue 2, 1999, Pages 195-200

  Mostafa, A M ^a   Abdel Naim, A B ^a   Abo Salem, O ^a   Abdel Aziz, A H ^a   Hamada, F M A ^a  

^a Al Azhar University   (Egypt)

Author keywords

Acrylonitrile; Bioactivation; Kidney

Indexed keywords

3 METHYLCHOLANTHRENE; 4 METHYLPYRAZOLE; ACRYLONITRILE; ALCOHOL; BENZIMIDAZOLE; CYANIDE; CYSTEINE; GLUTATHIONE; INDUSTRIAL CHEMICAL; MAGNESIUM ION; MERCAPTAMINE; MERCAPTOETHANOL; PENICILLAMINE; PHENOBARBITAL; PROADIFEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; KIDNEY METABOLISM; MALE; MICROSOME; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032796931     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1999.0502     Document Type: Article

References (38)

1. Reisch MS. Top 50 chemicals production stagnated last year. Chem Eng News 1992; 70: 16-22.
2. IARC. Monographs on the evaluation of the carcinogenic risk of chemicals to humans. Some monomers, plastics and synthetic elastomers and acrolein. 1979; 19: 83-113.
3. Parker S, Bradern M. Soft prosthesis materials based on powdered elastomers. Biomaterials 1990; 11: 482-90.
4. Kessler L, Finget M, Aprahamian M, Poinsot D, Keipes M, Damage C. Diffusion properties of an artificial membrane used for Langerhans islets encapsulation: interest of an in vitro test. Transplant Proc 1992; 24: 953-4.
5. Ward RA, Schaefer RM, Falkenhagen D, Joshua MS, Heidland A, Klinkmann H, Gurland HJ. Biocompatibility of a new high-permeability modified cellulose membrane for haemodialysis. Nephron Dialysis Transpl 1993; 8(1): 47-53.
6. Rubio R, Galceran MT, Rauret G. Nitriles and isonitriles as interferents in cyanide determination in polluted water. Analyst 1990; 115(7): 959-63.
7. Conacher HB, Page BD, Ryan JJ. Industrial chemical contaminants of foods. Food Addit Contam 1993; 10: 129-43.
8. Kondakova LV, Fomina El, Alekseeva OV. Composition of volatile thermo-destruction components of automobile brake straps. Gig Tr Prof Zabol 1990; 3: 18-21.
9. Byrd GD, Fowler KW, Hicks RD, Lovette ME, Borgerding MF. Isotope dilution gas chromatography-mass spectrometry in the determination of benzene, toluene, styrène and acrylonitrile in mainstream cigarette smoke. J Chromatogr 1990; 503: 359-68.
10. Solionova LG, Smulevich VB, Turbin EV, Krivosheyeva LV, Plotnikov JV. Carcinogens in rubber production in the Soviet Union. Scand J Work Environ Health 1992; 18: 120-3.
11. Duverger-van Bogaert M, Lambotte-Vandepaer M, De Meester C, Rollmann B, Poncelet F, Mercier M. Effect of several factors on the liver extract mediated mutagenicity of acrylonitrile and identification of four new in vitro metabolites. Toxicol Lett 1981; 7: 311-19.
12. Hamada FM, Abdel-Aziz AH, Abd-Allah AR, Ahmed AE. Possible functional immunotoxicity of acrylonitrile. PharmacolRes 1998; 37(2): 123-9.
13. Quast JF, Wade CE, Humiston CG, Carreon RM, Hermann EA, Park CN, Schweiz BA. A two-year toxicity and oncogenicity study with acrylonitrile incorporated into drinking water of rats. Prepared by the Toxicology Research Laboratory, Health and Environmental Research, Dow Chemical, Midland, MI, USA, 1980.
14. Saillenfait AM, Bonnet P, Guenier JP, de-Ceaurriz J. Relative developmental toxicities of inhaled aliphatic mononitriles. FundamAppl Toxicol 1993; 20: 365-75.
15. O'Berg MT. Epidemiological studies of workers exposed to acrylonitrile. J Occup Med 1980; 22: 245-52.
16. Delzell E, Monson RR. Mortality among rubber workers: VI. Men with potential exposure to acrylonitrile. J Occup Med 1982; 24: 767-9.
17. Chen JL, Fayerweather WE, Pell S. Cancer incidence of workers exposed to dimethylformamide and/or acrylonitrile. J Occup Med 1988; 30: 813-8.
18. Rouisse L, Chakrabarti S, Tuchweber B. Acute nephrotoxic potential of acrylonitrile in Ficher-344 rats. Res Com Chem Pathol Pharmacol 1986; 53(3): 347-60.
19. Zitting A, Tenhunen R, Savolainen H. Effect of intraperitoneally injected acrylonitrile on liver, kidney and brain. Ada Pharmacol Toxicol 1981; 49: 412-5.
20. Guengerich FP, Gieger LE, Hogy LL, Wright PL. In vitro metabolism of acrylonitrile to 1-cyanoethylene oxide, reaction with glutathione and irreversible binding to proteins and nucleic acids. Cancer Res 1981; 41: 4925-33.
21. Hogy LL, Guengerich FP. In vivo interaction of acrylonitrile and 2-cyanoethylene oxide DNA in rats. Cancer Res 1986; 46: 3932-8.
22. Subramanian U, Ahmed AE. Intestinal toxicity of acrylonitrile: In vitro metabolism by intestinal cytochrome P-450 IIE1. Toxicol Appl Pharmacol 1995; 135: 1-8.
23. Abdel-Aziz AH, Abdel-Naim AB, Hamada FM, Ahmed AE. In-vitro testicular bioactivation of acrylonitrile. Pharmacol Res 1997; 35(1): 129-34.
24. Abreu ME, Ahmed AE. Metabolism of acrylonitrile to cyanide: In vitro studies. Drug Metab Dispos 1980; 8: 376-9.
25. Feierman DE, Cederbaum AL. Role of cytochrome P-450 IIEI and catalase in oxidation of acetonitrile to cyanide. Chem Res Toxicol 1989; 2: 359-66.
26. Koop DR. Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3a. Mol Pharmacol 1986; 29: 399-404.
27. Farooqui, MYH, Diaz RG, Cavazos R. Metabolism of methacrylonitrile to cyanide: In vitro studies. J Biochem Toxicol 1990; 5: 109-14.
28. Lowry OH, Rosebrough NJ, Forr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-75.
29. Guengerich FP, Macdonal TL. Chemical mechanism of catalysis by cytochrome P-450: A unified view. Ace Chem Res 1984; 17: 9-16.
30. Guengerich FP, Liebler DC. Enzymatic activation of chemicals to toxic metabolites. CRC Crit Rev Toxicol 1985; 14: 259-307.
31. Farooqui MYH, Ahemd AE. In vivo interactions of acrylonitrile with macromolecules in rats. Chem Biol Interact 1983; 47: 363-71.
32. Cova D, Fumagalli P, Santagostino A. Toxicity of acrylonitrile in human neuroblastoma cell line and its effects on glutathione and glutathione-S-transferase. Bull Environ Contam Toxicol 1992; 49: 886-91.
33. Nebert DW, Gelboin HA. Substrate inducible microsomal arylhydratase in mammalian cultures. I. Assay and purification of induced enzyme. J Biol Chem 1968; 243: 6242-50.
34. Tamura M, Yoshida S, Tamura T, Satioh T, Takeshita M. Effect of divalent cations on NADH-dependent and NADPH-dependent cytochrome b5 reduction by hepatic microsomes. Arch Biochem Biophys 1990; 280: 313-91.
35. Gonzalez FJ. The molecular biology of cytochrome P-450s. Pharmacol Rev 1989; 40(4): 243-88.
36. Fasco MJ, Silkworth LB, Dunbar DA, Kaminsky LS. Rat small intestinal cytochrome P-450 probed by warfarin metabolism. Mol Pharmacol 1992; 43: 226-33.
37. Madan A, Parkinson A, Faiman MD. Role of flavin-dependent monooxygenases and cytochrome P-450 in the sulfoxidation of S-methyl N,N-dielhylthiocarbamate. Biochem Pharmacol 1993; 46: 2291-7.
38. Farber JL, Kyle ME, Coleman JB. Biology of disease mechanism of cell injury by activated oxygen species. Lab Invest 1990; 62: 670-9.