Topical use of local anesthetics in neonates

Pharmacy World and Science

Volumn 21, Issue 4, 1999, Pages 173-176

  Essink Tjebbes, C M ^a   Hekster, Y A ^a   Liem, K D ^a   Van Dongen, R T M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Effectiveness; Local anesthetics; Methemoglobinemia; Neonates; Safety; Topical

Indexed keywords

EMLA; LIDOCAINE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; HUMAN; LOCAL ANESTHESIA; MEDICAL INFORMATION; METHEMOGLOBINEMIA; NERVOUS SYSTEM; NEWBORN; OUTCOMES RESEARCH; PEDIATRIC ANESTHESIA; SKIN BLOOD FLOW; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANESTHETICS, LOCAL; CLINICAL TRIALS; HUMANS; INFANT, NEWBORN; LIDOCAINE; OINTMENTS; TETRACAINE; TREATMENT OUTCOME;

EID: 0032796665     PISSN: 09281231     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008623213199     Document Type: Article

References (39)

1. Choonara I. Management of pain in newborn infants. Seminars in Perinatology 1992;16(1):32-40.
2. Schechter NL. The undertreatment of pain in children: an overview. Pediatr Clin North Am 1989;36(4):781-94.
3. Anand KJS, Hickey PR. Pain and its effects in the human neonate and fetus. N Engl J Med 1987;317:1321-9.
4. Rogers MC. Do the right thing. Pain relief in infants and children. N Engl J Med 1987;326:55-6.
5. Yaster M, Tobin JR, Fisher QA, Maxwell LG. Local anesthetics in the management of acute pain in children. J Pediatr 1994;124:165-76.
6. Buckley MM, Benfield P. Eutectic lidocaine/prilocaine cream. A review of the topical anaesthetic/analgesic efficacy of a eutectic mixture of local aneaesthetics (EMLA). Drugs 1993;46(1):126-51.
7. Bunn HF. Methemoglobinemia. In: Nathans DG, Oski FA, eds. Hematology of infancy and childhood. 4th ed. Philadelphia: WB Saunders, 1993:720-727.
8. Duncan PG, Kobrinsky N. Prilocaine-induced methemoglobinemia in a newborn infant. Anaesthesiology 1983;59:75-6.
9. Kreutz RW, Kinni ME. Life-threatening toxic methemoglobinemia induced by prilocaine. Oral Surg 1983:480-82.
10. Voorbrood BS, Monnens LAH, Boon JM. Methemoglobinemie bij twee pasgeborenen ten gevolge van het gebruik van prilocaine (Citanest). Ned T Geneesk 1982;126(15):682-4.
11. Jakobson B, Nilsson A. Methemoglobinemia associated with a prilocaine-lidocaine cream and trimetoprim-sulphamethoxazole. A case report. Acta Anaesth Scand 1985;29:453-5.
12. Nioloux C, Floch-Tudal C, Jaby-Sergent MP, Lejeune C. Local anesthesia with EMLA cream and risk of methemoglobinemia in a premature infant. Arch Pediatr 1995;2(3):291-2.
13. Fitzgerald M, Millard C, Mc Intosh N. Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia. Pain 1989;39(1):31-6.
14. McIntosh N, Veen L van, Brameyer H. Alleviation of the pain of heel prick in preterm infants. Arch Dis Child Fetal Neonatal 1994;70(3):F177-81.
15. Larsson BA, Jylli L, Lagercrantz H, Olsson GL. Does a local anaesthetic cream (EMLA) alleviate pain from heel lancing in neonates? Acta Anaesth Scand 1995;39(8):1028-31.
16. Gourrier E, Karoubi P, El Hanache A, Merbouche S, Mouchnino G, Dhabhi S, et al. Use of EMLA cream in premature and full-term newborn infants. Study of efficacy and tolerance. Arch Pediatr 1995; 2(11): 1041-6.
17. Wester U. Analgesic effect of lidocaine ointment on intact skin in neonates. Acta Paediatr 1993;82:791.
18. Barker DP, Rutter N. Lignocaine ointment and local anaesthesia in preterm infants. Arch Dis Child 1995;72:F203-4.
19. Rushford JA, Griffiths G, Thorpe H, Levene MI. Can topical lignocaine reduce behavioural response to heel prick? Arch Dis Child 1995;72:F49-51.
20. Nilsson A, Engberg G, Henneberg S, Danielson K, Verdier CH de. Inverse relationship between age-dependent erythrocyte activity of methaemoglobin reductase and prilocaine-induced methaemoglobinaemia during infancy. Br J Anaesth 1990;64:72-6.
21. Taddio A, Shennan AT, Stevens B, Leeder JS, Koren G. Safety of lidocaine-prilocaine cream in the treatment of preterm neonates. J Pediatr 1995;127(6):1002-5.
22. Stevens B, Johnston C, Taddio A, Koren G, Aranda J. The safety and efficacy of emla for relieving procedural pain in preterm neonates. Pediatric Pain 1995, [Congres Proceedings Atlanta Nov 1995].
23. Gourrier E, Karoubi P, El Hanache A, Merbouche S, Mouchnino G, Leraillez J. Use of EMLA7 cream in a Department of Neonatology. Pain 1996;68:431-4.
24. Barret DA, Rutter N. Percutaneous lignocaine absorption in newborn infants. Arch Dis Child 1994;71:F122-4.
25. Berde CB. Toxicity of local anesthetics in infants and children. J Pediatr 1993;122:S14-S20.
26. Evans NJ, Rutter N. Development of the epidermis in the newborn. Biol Neonate 1986;49:74-80.
27. Juhlin L, Hägglund G, Evers H. Absorption of lidocaine and prilocaine after application of a eutectic mixture of local anesthetics (EMLA7) on normal and diseased skin, Acta Derm Venereol (Stockh) 1989;69:18-22.
28. McCafferty DF, Woolfson AD. New patch delivery system for percutaneous local anaesthesia. Br J Anaesth 1993;71(3):370-4.
29. Hallén B, Olsson GL, Uppfeldt A. Pain-free venepuncture. Effect of timing of application of local anaesthetic cream. Anaesth 1984;39(10):969-72.
30. Ehrenström-Reiz G, Reiz S, Stockman O. Topical anaesthesia with EMLA, a new lidocaine-prilocaine cream and the cusum technique for detection of minimal application time. Acta Anaesth Scand 1983;27:510-2.
31. Bjerring P, Arendt-Nielsen L. Depth and duration of skin analgesia to needle insertion after topical application of emla cream. Br J Anaesth 1990;64:173-7.
32. Larsson BA, Norman M, Bjerring P, Egekvist H, Lagercrantz H, Olsson GL. Regional variations in skin perfusion and skin thickness may contribute to varying efficacy of topical, local anaesthetics in neonates. Paediatr Anaesth 1996;6(2):107-10.
33. Haasio J, Jokinen T, Numminen M, Rosenberg PH. Topical anaesthesia of gingival mucosa by 5% eutectic mixture of lignocaine and prilocaine or by 10% lignocaine spray. Br J Oral Maxillofac Surg 1990;28(2):99-101.
34. Aliaga L, Santacana E. New developments in topical anaesthesia. A review of a novel eutectic mixture of local anaesthetics (EMLA). Research and Clin Forums 16:2.
35. Woolfson AD, McCafferty DF. Local anaesthesia of the skin. J Clin Pharm Ther 1989;14(2):103-9.
36. Gardavska K, Vitkova Z, Cizmarik J. Study of local anaesthetics: Influence of the ointment bases on the liberation of pentacaine chloride and heptacaine chloride. Acta Pharm Hun 1994;64:167-70.
37. Eyres RL, Bishop W, Oppenheim RC, Brown TCK. Plasma lignocaine concentrations following topical laryngeal application. Anaesth Intens Care 1983;11:23-6.
38. Gourrier E, Leraillez J. Risk of methemoglobinemia after EMLA application in premature infants. Arch Pediatr 1995;2(10):1021-2.
39. Mather LE, Cousins M. Local anaesthetics and their current clinical use. Drugs 1979;18(3):185-205.