Comparison of p53 and bcl-2 expression in initial, synchronous, and metachronous colorectal adenomas

Surgery Today

Volumn 29, Issue 8, 1999, Pages 707-712

  Watatani, Masahiro ^a   Ieda, Shintaro ^a   Kuroda, Kosaku ^a   Inui, Hiroki ^a   Nishimura, Keisuke ^a   Yasutomi, Masayuki ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bcl 2; Colorectal adenoma; Metachronous tumorigenesis; P53

Indexed keywords

BIOLOGICAL MARKER; PROTEIN BCL 2; PROTEIN P53;

ARTICLE; CANCER RISK; CARCINOGENESIS; COLORECTAL TUMOR; DYSPLASIA; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY;

EID: 0032796157     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02482313     Document Type: Article

References (34)

1. 1. Keer JFR, Wyllie AH, Currie AR (1972) Apoptosis; a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257
2. 2. Wyllie AH (1993) Apoptosis. Br J Cancer 67:206-208
3. 3. Stewart BW (1994) Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J Natl Cancer Inst 86:1286-1296
4. 4. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352:345-347
5. 5. Jacks T, Weinberg RA (1996) Cell-cycle control and its watchman. Nature 381:643-644
6. 6. Tsujimoto Y, Gorhan J, Cossman J, Jaffe E, Croce CM (1985) The t(14;18) chromosome translocation involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229:1390 1393
7. 7. Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperate with c-myc to immortalize pre-B bells. Nature 335:440-442
8. 8. Korsmeyer SJ (1992) Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 80:879-886
9. 9. Wang Y, Szekely L, Okan I, Klein G, Wiman KG (1993) Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma cell line. Oncogene 8:3427-3431
10. 10. Bussey HJR, Wallace MH, Morson BC (1967) Metachronous carcinoma of the large intestine and intestinal polyps. Proc R Soc Med 60:208-210
11. 11. Cali RL, Pitsch RM, Thorson AG, Watson P, Tapia P, Blatchford GJ, Christensen MA (1993) Cumulative incidence of metachronous colorectal cancer. Dis Colon Rectum 36:388-393
12. 12. Winawer SJ, Zauber AG, Stewart E, O'Brien MJ (1991) The natural history of colorectal cancer: opportunities for intervention. Cancer 67:1143-1149
13. 13. Atkin WS, Morson BC, Cuzick J (1992) Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med 326:658-662
14. 14. Griffioen G, Cornelisse CJ, Verspaget HW, Sier CFM, Eulderink F, Bosman FT, Lamers CBHW (1992) Association of aneuploidy in index adenomas with metachronous colorectal adenoma development and a comparison. Cancer 70:2035-2043
15. 15. Miura S, Shikata J, Hosoda Y (1992) Villous component as a marker for synchronous and metachronous colorectal adenomas. Dis Colon Rectum 35:1148-1153
16. 16. Tierney RP, Ballantyne GH, Modlin IM (1990) The adenoma to carcinoma sequence. Surg Gynecol Obstet 171:81-94
17. 17. Jass JR, Sobin LH (1989) International histological classification of tumours 15. Histological typing of intestinal tumours. WHO, Geneva
18. 18. Idea S, Watatani M, Yoshida T, Kuroda K, Inui H, Yasutomi M (1996) Immunohistochemical analysis of p53 and ras p21 expression in colorectal adenomas and early carcinomas. Surg Today 26:230-235
19. 19. Baretton GB, Diebold J, Christoforis G, Vogt M, Muller C, Dopfer K, Schneiderbanger K, Schmidt M, Lohrs U (1996) Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Cancer 77:255-264
20. 20. Watatani M, Ieda S, Kuroda K, Nishimura K, Yasutomi M (1996) Bcl-2 and p53 expression in metachronous colorectal adenomas compared with initial adenomas in relation to the degree of dysplasia. In: Tahara E, Sugimachi K, Oohara T (eds) Recent advances in gastroenterological carcinogenesis. Monduzzi Editore, Bologna, pp 371-375
21. 21. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Huffman B, Reed JC (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9:1799-1805
22. 22. Sinicrope FA, Ruan SB, Cleary KR, Stephens C, Lee JJ, Levin B (1995) Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 55:237-241
23. 23. Kaklamanis L, Gatter KC, Mortensen N, Baigrie RJ, Heryet A, Lane DP, Harris AL (1993) p53 expression in colorectal adenomas. Am J Pathol 142:87-93
24. 24. Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JKV, Hamilton S, Vogelstein B (1990) p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50:7717-7722
25. 25. Bosari S, Moneghini L, Graziani D, Lee AKC, Murray JJ, Coggl G, Viale G (1995) Bcl-2 oncoprotein in colorectal hyper-plastic polyps, adenomas, and adenocarcinomas. Hum Pathol 26:534-540
26. 26. Winawer SJ (1995) Surveillance of patients with polyps. In: Cohen AM, Winawer SJ, Friedman MA et al (eds) Cancer of the colon, rectum, and anus. McGraw-Hill, New York, pp 345-350
27. 27. Deschner EE, Winawer SJ, Long FC, Boyle CC (1977) Early detection of colonic neoplasia in patients at high risk. Cancer 40:2625-2631
28. 28. Terpstra OT, Blankenstein M, Dees J, Eilers GAM (1987) Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or carcinoma. Gastroenterology 92:704-708
29. 29. Garewal H, Bernstein H, Bernstein C, Sampliner R, Payne C (1996) Reduced bile acid-induced apoptosis in "normal" colorectal micosa: a potential biological marker for cancer risk. Cancer Res 56:1480-1483
30. 30. Fontanini G, Vignati S, Bigini D, Mussi A, Lucchi M, Angeletti CA, Basolo F, Bevilacqua G (1995) Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer. Br J Cancer 71:1003-1007
31. 31. Silvestrini R, Veneroni S, Daidone MG, Benini E, Boracchi P, Mezzetti M, Fronzo G, Rilke F, Veronesi U (1994) The Bcl-2 protein: a prognostic indictor strongly related to p53 protein in lymph node-negative breast cancer patients. J Natl Cancer Inst 86:499-504
32. 32. Pollina L, Pacini F, Fontanini G, Vignati S, Bevilacqua G, Basolo F (1996) Bcl-2, p53 and proliferating cell nuclear antigen expression is related to the degree of differentiation in thyroid carcinomas. Br J Cancer 73:139-143
33. 33. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362:849-852
34. 34. Purdie CA, O'Grady J, Piris J, Whillie AH, Bird CC (1991) p53 expression in colorectal tumors. Am J Pathol 138:807-813